Il33 interleukin 33 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il33provided by MGI
Official Full Name: interleukin 33provided by MGI
Primary source: MGI:MGI:1924375
See related: Ensembl:ENSMUSG00000024810 AllianceGenome:MGI:1924375
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il-33; Il1f11; NF-HEV; 9230117N10Rik
Summary: Enables cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; microglial cell activation involved in immune response; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 13.9), cerebellum adult (RPKM 10.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 24.56 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (29902513..29938118)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (29925113..29960718)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-33 Induces Cellular and Exosomal miR-146a Expression as a Feedback Inhibitor of Mast Cell Function.
Title: IL-33 Induces Cellular and Exosomal miR-146a Expression as a Feedback Inhibitor of Mast Cell Function.
The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis.
Title: The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis.
Staphylococcus aureus exacerbates dermal IL-33/ILC2 axis activation through evoking RIPK3/MLKL-mediated necroptosis of dry skin.
Title: Staphylococcus aureus exacerbates dermal IL-33/ILC2 axis activation through evoking RIPK3/MLKL-mediated necroptosis of dry skin.
Lack of S1PR2 in Macrophage Ameliorates Sepsis-associated Lung Injury through Inducing IL-33-mediated Type 2 Immunity.
Title: Lack of S1PR2 in Macrophage Ameliorates Sepsis-associated Lung Injury through Inducing IL-33-mediated Type 2 Immunity.
Tumor-infiltrating mast cells stimulate ICOS[+] regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression.
Title: Tumor-infiltrating mast cells stimulate ICOS(+) regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression.
Inhibition of IL-33 signaling ameliorate hepatic fibrosis with decreasing MCP-1 in a mouse model of diabetes and non-alcoholic steatohepatitis; comparison for luseogliflozin, an SGLT2 inhibitor.
Title: Inhibition of IL-33 signaling ameliorate hepatic fibrosis with decreasing MCP-1 in a mouse model of diabetes and non-alcoholic steatohepatitis; comparison for luseogliflozin, an SGLT2 inhibitor.
Interleukin-33 has the protective effect on oligodendrocytes against impairment induced by cuprizone intoxication.
Title: Interleukin-33 has the protective effect on oligodendrocytes against impairment induced by cuprizone intoxication.
Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways.
Title: Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways.
Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection.
Title: Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection.
Exploring the significance of interleukin-33/ST2 axis in minimal change disease.
Title: Exploring the significance of interleukin-33/ST2 axis in minimal change disease.

Submit: New GeneRIF Correction See all GeneRIFs (510)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (17) 1 citation
Endonuclease-mediated (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables interleukin-33 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-33-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in microglial cell activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in microglial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T-helper 1 type immune response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of immunoglobulin production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of inflammatory response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of leukocyte migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of CD80 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of CD86 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MHC class I biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cellular defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of immunoglobulin production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-13 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-4 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-5 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of nitric-oxide synthase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type 2 immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type 2 immune response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of type 2 immune response	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: interleukin-33

Names: nuclear factor from high endothelial venules

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.