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    Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 114644, updated on 23-Jun-2021

    Summary

    Official Symbol
    Slc13a3provided by MGI
    Official Full Name
    solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3provided by MGI
    Primary source
    MGI:MGI:2149635
    See related
    Ensembl:ENSMUSG00000018459
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NaD; NaDC; SDCT; NaDC3; SDCT2; NaDC-3
    Expression
    Biased expression in kidney adult (RPKM 238.1), liver E18 (RPKM 17.7) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Slc13a3 in Genome Data Viewer
    Location:
    2; 2 H3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165247215..165315117, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165405295..165473197, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (165230795..165298697, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 334 Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene origin of replication near adenosine deaminase Neighboring gene predicted gene 14437 Neighboring gene transformation related protein 53 regulating kinase A Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alpha-ketoglutarate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables citrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables citrate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dicarboxylic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables high-affinity sodium:dicarboxylate symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables organic acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium:dicarboxylate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sodium:dicarboxylate symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables succinate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables succinate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in anion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in aspartate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in citrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in citrate transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dicarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dicarboxylic acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutathione transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in succinate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in succinate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in succinate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier family 13 member 3
    Names
    Na(+)/dicarboxylate cotransporter 3
    mNaDC3
    sodium-dependent high-affinity dicarboxylate transporter 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054055.2NP_473396.1  solute carrier family 13 member 3

      See identical proteins and their annotated locations for NP_473396.1

      Status: PROVISIONAL

      Source sequence(s)
      AL591064
      Consensus CDS
      CCDS17081.1
      UniProtKB/Swiss-Prot
      Q91Y63
      UniProtKB/TrEMBL
      Q3UUJ6
      Related
      ENSMUSP00000029208.9, ENSMUST00000029208.15
      Conserved Domains (2) summary
      cd01115
      Location:42556
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
      TIGR00785
      Location:31565
      dass; anion transporter

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      165247215..165315117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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