Zwilch zwilch kinetochore protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zwilchprovided by MGI
Official Full Name: zwilch kinetochore proteinprovided by MGI
Primary source: MGI:MGI:1915264
See related: Ensembl:ENSMUSG00000032400 AllianceGenome:MGI:1915264
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310031L18Rik
Summary: Predicted to be involved in mitotic spindle assembly checkpoint signaling and protein localization to kinetochore. Predicted to act upstream of or within cell division. Predicted to be located in kinetochore. Predicted to be part of RZZ complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and skin. Orthologous to human ZWILCH (zwilch kinetochore protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 15.3), CNS E11.5 (RPKM 11.6) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 34.52 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (64044426..64080210, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (64137144..64173104, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to kinetochore	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RZZ complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RZZ complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein zwilch homolog

Names: Zwilch, kinetochore associated, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.