Tinagl1 tubulointerstitial nephritis antigen-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tinagl1provided by MGI
Official Full Name: tubulointerstitial nephritis antigen-like 1provided by MGI
Primary source: MGI:MGI:2137617
See related: Ensembl:ENSMUSG00000028776 AllianceGenome:MGI:2137617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AZ1; AZ-1; Arg1; Lcn7; TARP; Tinagl; 1110021J17Rik
Summary: Enables laminin binding activity. Predicted to be involved in proteolysis. Located in cytoplasm. Is expressed in several structures, including adrenal gland; blastocyst; brain ventricle; early embryo; and submandibular gland primordium. Orthologous to human TINAGL1 (tubulointerstitial nephritis antigen like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 158.0), placenta adult (RPKM 140.0) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 63.43 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (130059393..130068915, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (130165600..130175122, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection.
Title: Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection.
Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling.
Title: Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling.
Down-regulated TINAGL1 in fibroblasts impairs wound healing in diabetes.
Title: Down-regulated TINAGL1 in fibroblasts impairs wound healing in diabetes.
Tinagl1 is related to fertility in adult females but is not essential for either fertilization or preimplantation development in vitro
Title: Impaired female fertility in tubulointerstitial antigen-like 1-deficient mice.
Data show that endothelial cell lines SVEC but not MB114 cells express low levels of endogenous LCN7 mRNA and that overexpression significantly increased LCN7 mRNA over basal levels in both cell lines.
Title: Lipocalin-7 is a matricellular regulator of angiogenesis.
results suggest that tubulointerstitial nephritis antigen-like 1(Tinagl1) functions during the postimplantation period
Title: Tubulointerstitial nephritis antigen-like 1 is expressed in the uterus and binds with integrins in decidualized endometrium during postimplantation in mice.
In mouse embryos, the expression of both Tinagl1 mRNA and TINAGL1 protein was increased just prior to implantation. During postimplantation, TINAGL1 expression was restricted to extraembryonic regions.
Title: Tubulointerstitial nephritis antigen-like 1 is expressed in extraembryonic tissues and interacts with laminin 1 in the Reichert membrane at postimplantation in the mouse.
Collectively with the putative role of AZ-1 in the adrenocortical zonation, we propose that AZ-1 potentially regulates functions of adrenocortical and VSM cells by modulating cell-matrix interactions
Title: Adrenocortical zonation factor 1 is a novel matricellular protein promoting integrin-mediated adhesion of adrenocortical and vascular smooth muscle cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134342 (e-PCR)
- UniSTS:217624

D4Mit281 (e-PCR), detects polymorphism
- UniSTS:130072

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables laminin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tubulointerstitial nephritis antigen-like

Names: adrenocortical zonation factor 1; androgen-regulated gene 1 protein; tubulointerstitial nephritis antigen-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168333.1 → NP_001161805.1 tubulointerstitial nephritis antigen-like precursor

See identical proteins and their annotated locations for NP_001161805.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AB050626, AL606925

Consensus CDS

CCDS18708.2

UniProtKB/Swiss-Prot

Q99JR5, Q9EQT9

UniProtKB/TrEMBL

H3BJ97

Related

ENSMUSP00000101621.3, ENSMUST00000105999.9

Conserved Domains (3) summary

cd02620
Location:203 → 454

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam01033
Location:53 → 93

Somatomedin_B; Somatomedin B domain

cl17735
Location:104 → 152

VWC; von Willebrand factor type C domain
NM_023476.3 → NP_075965.2 tubulointerstitial nephritis antigen-like precursor

See identical proteins and their annotated locations for NP_075965.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL606925

Consensus CDS

CCDS18708.2

UniProtKB/Swiss-Prot

Q99JR5, Q9EQT9

UniProtKB/TrEMBL

H3BJ97

Related

ENSMUSP00000101620.2, ENSMUST00000105998.8

Conserved Domains (3) summary

cd02620
Location:203 → 454

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

pfam01033
Location:53 → 93

Somatomedin_B; Somatomedin B domain

cl17735
Location:104 → 152

VWC; von Willebrand factor type C domain