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    Mvd mevalonate (diphospho) decarboxylase [ Mus musculus (house mouse) ]

    Gene ID: 192156, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mvdprovided by MGI
    Official Full Name
    mevalonate (diphospho) decarboxylaseprovided by MGI
    Primary source
    MGI:MGI:2179327
    See related
    Ensembl:ENSMUSG00000006517 AllianceGenome:MGI:2179327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mpd
    Summary
    Predicted to enable Hsp70 protein binding activity; diphosphomevalonate decarboxylase activity; and protein homodimerization activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within cholesterol biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 27.0), kidney adult (RPKM 26.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mvd in Genome Data Viewer
    Location:
    8 E1; 8 71.05 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123160335..123170161, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122433596..122443422, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene interleukin 17C Neighboring gene cytochrome b-245, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E9324 Neighboring gene STARR-positive B cell enhancer ABC_E8269 Neighboring gene STARR-positive B cell enhancer ABC_E1776 Neighboring gene predicted gene, 53466 Neighboring gene predicted gene, 51557 Neighboring gene RIKEN cDNA 9330133O14 gene Neighboring gene STARR-positive B cell enhancer ABC_E567 Neighboring gene predicted gene, 20735 Neighboring gene snail family zinc finger 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Subcellular distribution of mouse mevalonate pyrophosphate decarboxylase. Michihara A, et al. Biol Pharm Bull, 2003 May. PMID 12736493
    2. Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation. Wadhwa R, et al. Biochem Biophys Res Commun, 2003 Mar 21. PMID 12646231
    3. Normalization of Hepatic Homeostasis in the Npc1(nmf164) Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat. Munkacsi AB, et al. J Biol Chem, 2017 Mar 17. PMID 28031458, Free PMC Article
    4. A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. Şişecioğlu M, et al. J Lipid Res, 2015 Aug. PMID 26108225, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results identify mevalonate pyrophosphate decarboxylase (MPD) as a binding partner of mortalin-2.
      Title: Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diphosphomevalonate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphomevalonate decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isoprenoid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    diphosphomevalonate decarboxylase
    Names
    MDDase
    mevalonate pyrophosphate decarboxylase
    NP_619597.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138656.2 → NP_619597.2  diphosphomevalonate decarboxylase

      See identical proteins and their annotated locations for NP_619597.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AK089354, AK134803, AL591003
      Consensus CDS
      CCDS22738.1
      UniProtKB/Swiss-Prot
      Q3TCD8, Q8BTM4, Q922D7, Q99JF5
      UniProtKB/TrEMBL
      Q3UYC1
      Related
      ENSMUSP00000006692.5, ENSMUST00000006692.6
      Conserved Domains (1) summary
      PLN02407
      Location:9 → 338
      PLN02407; diphosphomevalonate decarboxylase

    RNA

    1. NR_028354.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK089354, AK153439, AL591003
      Related
      ENSMUST00000211883.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123160335..123170161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JF5.2 GenPept UniProtKB/Swiss-Prot:Q99JF5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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