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    Ptges2 prostaglandin E synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 96979, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ptges2provided by MGI
    Official Full Name
    prostaglandin E synthase 2provided by MGI
    Primary source
    MGI:MGI:1917592
    See related
    Ensembl:ENSMUSG00000026820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gbf1; Pges2; C79137; Mpges2; 0610038H10Rik
    Summary
    The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 50.1), duodenum adult (RPKM 41.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ptges2 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32285902..32292752)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32395890..32402740)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32251410..32258260)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene bublin coiled coil protein Neighboring gene lipocalin 2 Neighboring gene predicted gene 13413 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Neighboring gene nuclear apoptosis inducing factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6845

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables prostaglandin-E synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables prostaglandin-E synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prostaglandin E synthase 2
    Names
    GATE-binding factor 1
    mPGES-2
    microsomal prostaglandin E synthase 2
    NP_598544.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133783.2NP_598544.2  prostaglandin E synthase 2

      See identical proteins and their annotated locations for NP_598544.2

      Status: REVIEWED

      Source sequence(s)
      AK050616, BE956255, CX221758
      Consensus CDS
      CCDS15914.1
      UniProtKB/Swiss-Prot
      Q8BWM0
      Related
      ENSMUSP00000028162.4, ENSMUST00000028162.5
      Conserved Domains (3) summary
      cd03197
      Location:223371
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
      COG0625
      Location:101368
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03040
      Location:100176
      GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32285902..32292752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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