Scly selenocysteine lyase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sclyprovided by MGI
Official Full Name: selenocysteine lyaseprovided by MGI
Primary source: MGI:MGI:1355310
See related: Ensembl:ENSMUSG00000026307 AllianceGenome:MGI:1355310
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SCL; mSCL; Scly1; Scly2; A930015N15Rik
Summary: Predicted to enable several functions, including protein homodimerization activity; selenocysteine lyase activity; and vitamin B6 binding activity. Acts upstream of or within several processes, including negative regulation of cellular response to oxidative stress; response to insulin; and selenium compound metabolic process. Predicted to be located in Golgi apparatus. Predicted to be part of catalytic complex. Is expressed in alimentary system; liver; and nervous system. Orthologous to human SCLY (selenocysteine lyase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 39.6), liver adult (RPKM 37.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 46.08 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (91226017..91248797)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (91298295..91321080)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studied the role of selenocysteine lyase in amino acid metabolism using knockout mice and a combination of transcriptomics and metabolomics.
Title: Combined Omics Reveals That Disruption of the Selenocysteine Lyase Gene Affects Amino Acid Pathways in Mice.
Loss of Scly within a neuronal sub-population that makes up a small fraction of the hypothalamus produces a phenotype in mice distinguished by reduced weight gain while on high fat diet and resistance to the development of leptin insensitivity.
Title: Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance.
Selenocysteine lyase regulates energy metabolism via the hypothalamus.
Title: Sexual Dimorphism in the Selenocysteine Lyase Knockout Mouse.
This study showed that Male mice lacking two key genes involved in Se metabolism (Scly(-/-)Sepp1(-/-) mice), selenoprotein P (Sepp1) and Sec lyase (Scly), develop severe neurological dysfunction, neurodegeneration, and audiogenic seizures.
Title: Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease.
our findings unveil a new metabolic role for Reg3beta in protein nitration and a new biosynthesis control of GPX1 by a completely "unrelated" regenerating protein, Reg3beta, via transcriptional activation of Scly
Title: A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3β aggravates acetaminophen-induced hepatic protein nitration.
These findings provide the first in vivo evidence that Scly and Sepp1 work cooperatively to maintain selenoprotein function in the mammalian brain.
Title: Mice lacking selenoprotein P and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures.
The results suggested a dependence of glucose and lipid homeostasis on selenocysteine lyase activity. These findings connect Se and energy metabolism and demonstrate for the first time a unique physiological role of selenocysteine lyase.
Title: Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice.
Scly knockout mice do not display neurological dysfunction comparable to Sepp1 knockout mice.
Title: Absence of selenoprotein P but not selenocysteine lyase results in severe neurological dysfunction.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables selenocysteine lyase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables vitamin B6 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within selenium compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in selenocysteine catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: selenocysteine lyase

Names: selenocysteine lyase; Selenocysteine reductase; selenocysteine reductase

NP_057926.2

EC 4.4.1.16

XP_006529806.2

EC 4.4.1.16

XP_006529807.1

EC 4.4.1.16

XP_006529808.1

EC 4.4.1.16

XP_006529809.1

EC 4.4.1.16

XP_036008194.1

EC 4.4.1.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016717.4 → NP_057926.2 selenocysteine lyase

See identical proteins and their annotated locations for NP_057926.2

Status: VALIDATED

Source sequence(s)

AC102874, AC110510

Consensus CDS

CCDS15159.1

UniProtKB/Swiss-Prot

Q8CB57, Q8CB94, Q9JLI6

UniProtKB/TrEMBL

A0A0R4J069

Related

ENSMUSP00000027532.7, ENSMUST00000027532.13

Conserved Domains (2) summary

COG1104
Location:18 → 428

NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]

pfam00266
Location:20 → 416

Aminotran_5; Aminotransferase class-V

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

91226017..91248797

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529744.4 → XP_006529807.1 selenocysteine lyase isoform X2

UniProtKB/Swiss-Prot

Q8CB57, Q8CB94, Q9JLI6

Conserved Domains (1) summary

COG1104
Location:66 → 474

NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]
XM_006529746.4 → XP_006529809.1 selenocysteine lyase isoform X5

UniProtKB/Swiss-Prot

Q8CB57, Q8CB94, Q9JLI6

Conserved Domains (1) summary

cl18945
Location:1 → 356

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_006529743.2 → XP_006529806.2 selenocysteine lyase isoform X1

UniProtKB/Swiss-Prot

Q8CB57, Q8CB94, Q9JLI6

Conserved Domains (1) summary

COG1104
Location:40 → 450

NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]
XM_036152301.1 → XP_036008194.1 selenocysteine lyase isoform X3

UniProtKB/Swiss-Prot

Q8CB57, Q8CB94, Q9JLI6

Conserved Domains (1) summary

COG1104
Location:44 → 454

NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]
XM_006529745.4 → XP_006529808.1 selenocysteine lyase isoform X4

UniProtKB/Swiss-Prot

Q8CB57, Q8CB94, Q9JLI6

Conserved Domains (1) summary

COG1104
Location:28 → 438

NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]