Apoc3 apolipoprotein C-III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apoc3provided by MGI
Official Full Name: apolipoprotein C-IIIprovided by MGI
Primary source: MGI:MGI:88055
See related: Ensembl:ENSMUSG00000032081 AllianceGenome:MGI:88055
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: apo-CIII; apoC-III
Summary: This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression: Biased expression in liver adult (RPKM 1808.2), duodenum adult (RPKM 768.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 25.36 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (46144348..46146934, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (46233050..46235636, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated pyroptosis of macrophages through mitochondrial damage by accelerating of the interaction between SCIMP and SYK pathway in acute lung injury.
Title: Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated pyroptosis of macrophages through mitochondrial damage by accelerating of the interaction between SCIMP and SYK pathway in acute lung injury.
Apolipoprotein C3: form begets function.
Title: Apolipoprotein C3: form begets function.
Silencing ApoC3 alleviates LPS-induced acute lung injury by inhibiting TLR signaling pathway.
Title: Silencing ApoC3 alleviates LPS-induced acute lung injury by inhibiting TLR signaling pathway.
ApoC3 is expressed in oocytes and increased expression is associated with PCOS progression.
Title: ApoC3 is expressed in oocytes and increased expression is associated with PCOS progression.
Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering.
Title: Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering.
Downregulation of NK cell activities in Apolipoprotein C-III-induced hyperlipidemia resulting from lipid-induced metabolic reprogramming and crosstalk with lipid-laden dendritic cells.
Title: Downregulation of NK cell activities in Apolipoprotein C-III-induced hyperlipidemia resulting from lipid-induced metabolic reprogramming and crosstalk with lipid-laden dendritic cells.
Apolipoprotein C3 aggravates diabetic nephropathy in type 1 diabetes by activating the renal TLR2/NF-kappaB pathway.
Title: Apolipoprotein C3 aggravates diabetic nephropathy in type 1 diabetes by activating the renal TLR2/NF-κB pathway.
data indicate that apoE determines the metabolic impact of apoC-III as we establish that apoE is essential to mediate inhibition of TRL clearance by apoC-III and that, in the absence of functional apoE, apoC-III inhibits tissue LPL activity.
Title: ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance.
observations demonstrate that relative insulin deficiency increases APOC3 and that this results in elevated levels of TRLs and accelerated atherosclerosis in a mouse model of T1DM.
Title: Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes.
Both triglyceride-rich lipoproteins (TRLs) and ApoCIII contribute to the progression of atherosclerosis, and the modulation of TRLs and ApoCIII may represent a novel therapeutic approach against hypertriglyceridemia induced atherosclerosis.
Title: Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

PMC123053P1 (e-PCR)
- UniSTS:270429

D9Mit93 (e-PCR), detects polymorphism
- UniSTS:131980

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme regulator activity	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables high-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables lipase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chylomicron remnant clearance	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of high-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of Cdc42 protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within triglyceride mobilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
part_of chylomicron	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of intermediate-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of intermediate-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein C-III

Names: apolipoprotein C3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289755.1 → NP_001276684.1 apolipoprotein C-III isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC116503

Consensus CDS

CCDS80989.1

UniProtKB/TrEMBL

E9QP56

Related

ENSMUSP00000113126.2, ENSMUST00000121916.8

Conserved Domains (1) summary

pfam05778
Location:61 → 128

Apo-CIII; Apolipoprotein CIII (Apo-CIII)
NM_001289756.1 → NP_001276685.1 apolipoprotein C-III isoform b precursor

See identical proteins and their annotated locations for NP_001276685.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same protein.

Source sequence(s)

AC116503, AK008260, W61891

Consensus CDS

CCDS23141.1

UniProtKB/Swiss-Prot

P33622, Q8VC58, Q9CPP9

UniProtKB/TrEMBL

A0A0R4J1N3

Related

ENSMUSP00000113058.2, ENSMUST00000118649.8

Conserved Domains (1) summary

pfam05778
Location:23 → 90

Apo-CIII; Apolipoprotein CIII (Apo-CIII)
NM_001289833.1 → NP_001276762.1 apolipoprotein C-III isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus compared to isoform a.

Source sequence(s)

AC116503

Related

ENSMUST00000214729.2

Conserved Domains (1) summary

pfam05778
Location:1 → 55

Apo-CIII; Apolipoprotein CIII (Apo-CIII)
NM_023114.4 → NP_075603.1 apolipoprotein C-III isoform b precursor

See identical proteins and their annotated locations for NP_075603.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same protein.

Source sequence(s)

AC116503, AK008260

Consensus CDS

CCDS23141.1

UniProtKB/Swiss-Prot

P33622, Q8VC58, Q9CPP9

UniProtKB/TrEMBL

A0A0R4J1N3

Related

ENSMUSP00000034586.3, ENSMUST00000034586.9

Conserved Domains (1) summary

pfam05778
Location:23 → 90

Apo-CIII; Apolipoprotein CIII (Apo-CIII)