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    Hal histidine ammonia lyase [ Mus musculus (house mouse) ]

    Gene ID: 15109, updated on 6-Jun-2021

    Summary

    Official Symbol
    Halprovided by MGI
    Official Full Name
    histidine ammonia lyaseprovided by MGI
    Primary source
    MGI:MGI:96010
    See related
    Ensembl:ENSMUSG00000020017
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hs; Hsd; his; hist; histidase
    Summary
    This gene encodes a member of the histidase protein family. The encoded protein is a cytosolic enzyme which catalyzes the first reaction in histidine catabolism. Defects in this protein cause histidinemia, which is characterized by increased histidine in blood, urine, and cerebrospinal fluid. [provided by RefSeq, Dec 2015]
    Expression
    Restricted expression toward liver adult (RPKM 120.3) See more
    Orthologs
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    Genomic context

    See Hal in Genome Data Viewer
    Location:
    10 C2; 10 48.49 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93324630..93352623)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93488768..93516761)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (92951513..92979488)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115487419 Neighboring gene nuclear encoded tRNA aspartic acid 8 (anticodon GTC) Neighboring gene leukotriene A4 hydrolase Neighboring gene amidohydrolase domain containing 1 Neighboring gene coiled-coil domain containing 38 Neighboring gene small nuclear ribonucleoprotein polypeptide F

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histidine ammonia-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histidine ammonia-lyase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histidine ammonia-lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in histidine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within histidine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within histidine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    histidine ammonia-lyase
    NP_034531.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010401.4NP_034531.1  histidine ammonia-lyase

      See identical proteins and their annotated locations for NP_034531.1

      Status: REVIEWED

      Source sequence(s)
      AK014518, AK028963
      Consensus CDS
      CCDS36036.1
      UniProtKB/Swiss-Prot
      P35492
      UniProtKB/TrEMBL
      B2RXW1, Q8CE60
      Related
      ENSMUSP00000123336.2, ENSMUST00000129421.8
      Conserved Domains (2) summary
      TIGR01225
      Location:114625
      hutH; histidine ammonia-lyase
      pfam12053
      Location:1578
      DUF3534; Domain of unknown function (DUF3534)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93324630..93352623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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