Star steroidogenic acute regulatory protein [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Starprovided by MGI
Official Full Name: steroidogenic acute regulatory proteinprovided by MGI
Primary source: MGI:MGI:102760
See related: Ensembl:ENSMUSG00000031574 AllianceGenome:MGI:102760
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: stARD1; D8Ertd419e
Summary: Predicted to enable cholesterol binding activity. Acts upstream of or within cellular lipid metabolic process; glucocorticoid metabolic process; and regulation of steroid biosynthetic process. Located in mitochondrion. Is expressed in several structures, including adrenal gland; extraembryonic component; and reproductive system. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward adrenal adult (RPKM 849.8) See more
Orthologs: human all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (26298502..26306010)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (25808474..25815982)

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zonal expression of StARD1 and oxidative stress in alcoholic-related liver disease.
Title: Zonal expression of StARD1 and oxidative stress in alcoholic-related liver disease.
Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer.
Title: Expression and Function of StAR in Cancerous and Non-Cancerous Human and Mouse Breast Tissues: New Insights into Diagnosis and Treatment of Hormone-Sensitive Breast Cancer.
Regulation of retinoid mediated StAR transcription and steroidogenesis in hippocampal neuronal cells: Implications for StAR in protecting Alzheimer's disease.
Title: Regulation of retinoid mediated StAR transcription and steroidogenesis in hippocampal neuronal cells: Implications for StAR in protecting Alzheimer's disease.
A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis.
Title: A Short Promoter Region Containing Conserved Regulatory Motifs Is Required for Steroidogenic Acute Regulatory Protein (Star) Gene Expression in the Mouse Testis.
Role of Constitutive STAR in Mitochondrial Structure and Function in MA-10 Leydig Cells.
Title: Role of Constitutive STAR in Mitochondrial Structure and Function in MA-10 Leydig Cells.
Transcriptional regulation of HIF1alpha-mediated STAR expression in murine KK1 granulosa cell line involves cJUN, CREB and CBP-dependent pathways.
Title: Transcriptional regulation of HIF1α-mediated STAR expression in murine KK1 granulosa cell line involves cJUN, CREB and CBP-dependent pathways.
STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway.
Title: STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway.
Interleukin-1alpha dependent survival of cardiac fibroblasts is associated with StAR/STARD1 expression and improved cardiac remodeling and function after myocardial infarction.
Title: Interleukin-1α dependent survival of cardiac fibroblasts is associated with StAR/STARD1 expression and improved cardiac remodeling and function after myocardial infarction.
Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation.
Title: Acid ceramidase improves mitochondrial function and oxidative stress in Niemann-Pick type C disease by repressing STARD1 expression and mitochondrial cholesterol accumulation.
Developmental expression of genes involved in progesterone synthesis, metabolism and action during the post-natal cerebellar myelination.
Title: Developmental expression of genes involved in progesterone synthesis, metabolism and action during the post-natal cerebellar myelination.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Markers

AV363654 (e-PCR)
- UniSTS:179722

PMC203309P4 (e-PCR)
- UniSTS:271901

Star (e-PCR), detects polymorphism
- UniSTS:531491

Star (e-PCR), detects polymorphism
- UniSTS:531495

NoName (e-PCR)
- UniSTS:224815

RH142227 (e-PCR)
- UniSTS:231477

Star (e-PCR), detects polymorphism
- UniSTS:464695

Star (e-PCR), detects polymorphism
- UniSTS:474704

PMC140651P3 (e-PCR)
- UniSTS:270948

L36062 (e-PCR)
- UniSTS:163434

BB283182 (e-PCR)
- UniSTS:208256

RH127222 (e-PCR)
- UniSTS:167571

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in estrogen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucocorticoid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of steroid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial crista	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: steroidogenic acute regulatory protein, mitochondrial

Names: START domain-containing protein 1; luteinizing hormone-induced protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011485.5 → NP_035615.2 steroidogenic acute regulatory protein, mitochondrial precursor

See identical proteins and their annotated locations for NP_035615.2

Status: VALIDATED

Source sequence(s)

AK019725, AK054470, AK136327

Consensus CDS

CCDS22203.1

UniProtKB/Swiss-Prot

P51557, Q543A5, Q924Y5, Q9D2G1

Related

ENSMUSP00000033979.5, ENSMUST00000033979.6

Conserved Domains (1) summary

cd08905
Location:69 → 277

START_STARD1-like; Cholesterol-binding START domain of mammalian STARD1 and related proteins