U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Bcl9l B cell CLL/lymphoma 9-like [ Mus musculus (house mouse) ]

    Gene ID: 80288, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Bcl9lprovided by MGI
    Official Full Name
    B cell CLL/lymphoma 9-likeprovided by MGI
    Primary source
    MGI:MGI:1933114
    See related
    Ensembl:ENSMUSG00000063382 AllianceGenome:MGI:1933114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B9L; BCL9-2; DLNB11
    Summary
    Enables beta-catenin binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; skeletal muscle cell differentiation; and somatic stem cell population maintenance. Located in nucleus. Is expressed in several structures, including respiratory system cartilage; sensory organ; skeleton; trunk unsegmented mesenchyme; and vibrissa. Orthologous to human BCL9L (BCL9 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 17.6), lung adult (RPKM 16.5) and 26 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Bcl9l in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44394103..44423203)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44482738..44511906)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 103, member A1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5064 Neighboring gene predicted gene, 22540 Neighboring gene STARR-positive B cell enhancer ABC_E5065 Neighboring gene STARR-positive B cell enhancer ABC_E10541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44323517-44323626 Neighboring gene STARR-positive B cell enhancer ABC_E5066 Neighboring gene C-X-C motif chemokine receptor 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44345968-44346210 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44348167-44348368 Neighboring gene predicted gene, 50603 Neighboring gene STARR-positive B cell enhancer mm9_chr9:44379241-44379542 Neighboring gene STARR-seq mESC enhancer starr_23977 Neighboring gene STARR-positive B cell enhancer ABC_E6727 Neighboring gene STARR-seq mESC enhancer starr_23980 Neighboring gene STARR-positive B cell enhancer ABC_E10542 Neighboring gene DEAD-box helicase 6 Neighboring gene predicted gene, 30671

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis. Zatula N, et al. Oncotarget, 2014 Aug 30. PMID 25149534, Free PMC Article
    2. BCL9-2 promotes early stages of intestinal tumor progression. Brembeck FH, et al. Gastroenterology, 2011 Oct. PMID 21703997
    3. Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers. Toya H, et al. Cancer Sci, 2007 Apr. PMID 17309600
    4. Identification and characterization of human BCL9L gene and mouse Bcl9l gene in silico. Katoh M, et al. Int J Mol Med, 2003 Oct. PMID 12964048
    5. Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells. Borrelli C, et al. Nat Commun, 2021 Mar 1. PMID 33649334, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
      Title: BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
    2. Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
      Title: A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
    3. BCL9-2 induces ER positive breast cancers in vivo, regulates ER expression by a novel ss-catenin independent mechanism in breast cancer cells.
      Title: The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.
    4. Data show that the GCM1/syncytin-B pathway is significantly downregulated in the placenta of BCL9L-deficient mice and that the fusion and differentiation of ST-II cells are blocked.
      Title: Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.
    5. BCL9-2 promotes early phases of intestinal tumor progression in humans and in transgenic mice. BCL9-2 increases the expression of a subset of canonical Wnt target genes but also regulates genes that are required for early stages of tumor progression.
      Title: BCL9-2 promotes early stages of intestinal tumor progression.
    6. We demonstrated that nuclear B9L expression was closely associated with the high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers.
      Title: Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (4) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC7014

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within myoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of beta-catenin-TCF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    B-cell CLL/lymphoma 9-like protein
    Names
    B-cell lymphoma 9-like protein
    BCL9-like protein
    BCL9-related beta-catenin-binding protein
    nuclear co-factor of beta-catenin signalling
    protein BCL9-2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357490.2 → NP_001344419.1  B-cell CLL/lymphoma 9-like protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC122428, AC125129
      Consensus CDS
      CCDS90549.1
      Related
      ENSMUSP00000151342.2, ENSMUST00000220303.2
      Conserved Domains (2) summary
      PHA03247
      Location:832 → 1314
      PHA03247; large tegument protein UL36; Provisional
      pfam11502
      Location:358 → 392
      BCL9; B-cell lymphoma 9 protein

    2. NM_001421307.1 → NP_001408236.1  B-cell CLL/lymphoma 9-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122428, AC125129
      UniProtKB/Swiss-Prot
      Q641L9, Q67FY2, Q6GQY0, Q6I7B5

    3. NM_030256.4 → NP_084532.2  B-cell CLL/lymphoma 9-like protein isoform 1

      See identical proteins and their annotated locations for NP_084532.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC125129
      Consensus CDS
      CCDS40601.1
      UniProtKB/Swiss-Prot
      Q641L9, Q67FY2, Q6GQY0, Q6I7B5
      Related
      ENSMUSP00000074516.6, ENSMUST00000074989.7
      Conserved Domains (2) summary
      PHA03247
      Location:869 → 1351
      PHA03247; large tegument protein UL36; Provisional
      pfam11502
      Location:395 → 429
      BCL9; B-cell lymphoma 9 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44394103..44423203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244728.1 → XP_030100588.1  B-cell CLL/lymphoma 9-like protein isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:832 → 1314
      PHA03247; large tegument protein UL36; Provisional
      pfam11502
      Location:358 → 392
      BCL9; B-cell lymphoma 9 protein

    2. XM_006510703.4 → XP_006510766.1  B-cell CLL/lymphoma 9-like protein isoform X1

      See identical proteins and their annotated locations for XP_006510766.1

      UniProtKB/Swiss-Prot
      Q641L9, Q67FY2, Q6GQY0, Q6I7B5
      Conserved Domains (2) summary
      PHA03247
      Location:869 → 1351
      PHA03247; large tegument protein UL36; Provisional
      pfam11502
      Location:395 → 429
      BCL9; B-cell lymphoma 9 protein

    3. XM_006510702.5 → XP_006510765.1  B-cell CLL/lymphoma 9-like protein isoform X1

      See identical proteins and their annotated locations for XP_006510765.1

      UniProtKB/Swiss-Prot
      Q641L9, Q67FY2, Q6GQY0, Q6I7B5
      Related
      ENSMUSP00000151837.2, ENSMUST00000218183.2
      Conserved Domains (2) summary
      PHA03247
      Location:869 → 1351
      PHA03247; large tegument protein UL36; Provisional
      pfam11502
      Location:395 → 429
      BCL9; B-cell lymphoma 9 protein

    4. XM_036155412.1 → XP_036011305.1  B-cell CLL/lymphoma 9-like protein isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:832 → 1314
      PHA03247; large tegument protein UL36; Provisional
      pfam11502
      Location:358 → 392
      BCL9; B-cell lymphoma 9 protein

    5. XM_006510704.4 → XP_006510767.1  B-cell CLL/lymphoma 9-like protein isoform X1

      See identical proteins and their annotated locations for XP_006510767.1

      UniProtKB/Swiss-Prot
      Q641L9, Q67FY2, Q6GQY0, Q6I7B5
      Conserved Domains (2) summary
      PHA03247
      Location:869 → 1351
      PHA03247; large tegument protein UL36; Provisional
      pfam11502
      Location:395 → 429
      BCL9; B-cell lymphoma 9 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q67FY2.1 GenPept UniProtKB/Swiss-Prot:Q67FY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous