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    Otc ornithine transcarbamylase [ Mus musculus (house mouse) ]

    Gene ID: 18416, updated on 23-Jun-2021

    Summary

    Official Symbol
    Otcprovided by MGI
    Official Full Name
    ornithine transcarbamylaseprovided by MGI
    Primary source
    MGI:MGI:97448
    See related
    Ensembl:ENSMUSG00000031173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sf; spf; AI265390
    Expression
    Biased expression in liver adult (RPKM 25.6), liver E18 (RPKM 13.3) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Otc in Genome Data Viewer
    Location:
    X A1.1; X 4.66 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (10118500..10187263)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (10252230..10321024)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (9829485..9898150)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33844 Neighboring gene retinitis pigmentosa GTPase regulator Neighboring gene predicted gene, 54080 Neighboring gene ferritin light chain pseudogene Neighboring gene predicted gene, 54081

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (2)  1 citation
    • Targeted (1)  1 citation
    • Radiation induced (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxyl- or carbamoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ornithine carbamoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ornithine carbamoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ammonium homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in arginine biosynthetic process via ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in citrulline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in citrulline biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ornithine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ornithine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in urea cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ornithine transcarbamylase, mitochondrial; ornithine carbamoyltransferase, mitochondrial
    Names
    OTCase
    NP_032795.1
    XP_011245751.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008769.4NP_032795.1  ornithine transcarbamylase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_032795.1

      Status: VALIDATED

      Source sequence(s)
      AK050930, AL671042, BY090290
      Consensus CDS
      CCDS30015.1
      UniProtKB/Swiss-Prot
      P11725
      UniProtKB/TrEMBL
      Q543H3
      Related
      ENSMUSP00000056152.7, ENSMUST00000049910.13
      Conserved Domains (3) summary
      PRK00779
      Location:36342
      PRK00779; ornithine carbamoyltransferase; Provisional
      pfam00185
      Location:188341
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam02729
      Location:41181
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      10118500..10187263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247449.4XP_011245751.1  ornithine carbamoyltransferase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011245751.1

      UniProtKB/TrEMBL
      Q8R1A8
      Related
      ENSMUSP00000111190.3, ENSMUST00000115528.3
      Conserved Domains (1) summary
      PRK00779
      Location:36330
      PRK00779; ornithine carbamoyltransferase; Provisional
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