Bcl2l1 BCL2-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcl2l1provided by MGI
Official Full Name: BCL2-like 1provided by MGI
Primary source: MGI:MGI:88139
See related: Ensembl:ENSMUSG00000007659 AllianceGenome:MGI:88139
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BclX; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1
Summary: This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]
Expression: Ubiquitous expression in thymus adult (RPKM 18.5), liver E14.5 (RPKM 15.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 75.41 cM; 2 H1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (152600652..152673632, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (152758732..152833803, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth.
Title: Bcl-xL targeting eliminates ageing tumor-promoting neutrophils and inhibits lung tumor growth.
O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation.
Title: O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL and Oxidative Phosphorylation.
Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis.
Title: Bcl2l1 Deficiency in Osteoblasts Reduces the Trabecular Bone Due to Enhanced Osteoclastogenesis Likely through Osteoblast Apoptosis.
Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice.
Title: Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice.
Burn-Induced Apoptosis in the Livers of Aged Mice Is Associated With Caspase Cleavage of Bcl-xL.
Title: Burn-Induced Apoptosis in the Livers of Aged Mice Is Associated With Caspase Cleavage of Bcl-xL.
Genetically prolonged beige fat in male mice confers long-lasting metabolic health.
Title: Genetically prolonged beige fat in male mice confers long-lasting metabolic health.
BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis.
Title: BCL-xL inhibition potentiates cancer therapies by redirecting the outcome of p53 activation from senescence to apoptosis.
Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer.
Title: Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer.
ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis.
Title: ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis.
Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis.
Title: Malignant pleural mesothelioma co-opts BCL-X(L) and autophagy to escape apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (185)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BCL2L1 (e-PCR)
- UniSTS:505873

PMC156147P6 (e-PCR)
- UniSTS:271383

Bcl2l (e-PCR), detects polymorphism
- UniSTS:225854

PMC20354P5 (e-PCR)
- UniSTS:271938

NoName (e-PCR)
- UniSTS:548181

PMC316415P1 (e-PCR)
- UniSTS:272987

PMC123054P2 (e-PCR)
- UniSTS:270431

Bcl2l (e-PCR), detects polymorphism
- UniSTS:141167

Bcl2l (e-PCR), detects polymorphism
- UniSTS:141168

Bcl2l1 (e-PCR), detects polymorphism
- UniSTS:531319

BB166591 (e-PCR)
- UniSTS:185506

UniSTS:224427 (e-PCR)
- UniSTS:224427

PMC305873P1 (e-PCR)
- UniSTS:272567

PMC196230P1 (e-PCR)
- UniSTS:271802

Bcl2l1 (e-PCR), detects polymorphism
- UniSTS:532418

PMC262691P1 (e-PCR)
- UniSTS:272323

PMC262691P2 (e-PCR)
- UniSTS:272324

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BH domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables BH domain binding	ISO Inferred from Sequence Orthology more info
enables BH3 domain binding	ISO Inferred from Sequence Orthology more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables MDM2/MDM4 family protein binding	ISO Inferred from Sequence Orthology more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process in bone marrow cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to alkaloid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to amino acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of dendritic cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of dendritic cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fertilization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within germ cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of dendritic cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of developmental process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mononuclear cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within release of cytochrome c from mitochondria	IGI Inferred from Genetic Interaction more info	PubMed
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cycloheximide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to cytokine	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to radiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to virus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle recycling via endosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Bcl-2 family protein complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
colocalizes_with clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
colocalizes_with synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bcl-2-like protein 1

Names: B-cell leukemia/lymphoma x; anti-apoptosis regulatory protein; apoptosis regulator Bcl-X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289716.2 → NP_001276645.1 bcl-2-like protein 1 isoform a

See identical proteins and their annotated locations for NP_001276645.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1, 2, 3, and 5 all encode the same isoform (a, also known as Bcl-xL; PMID 7607090).

Source sequence(s)

AL731857

Consensus CDS

CCDS16899.1

UniProtKB/Swiss-Prot

O35844, Q60657, Q60658, Q61338, Q64373

UniProtKB/TrEMBL

Q3T9W4, Q5HZH3

Related

ENSMUSP00000105445.4, ENSMUST00000109820.5

Conserved Domains (1) summary

TIGR00865
Location:1 → 233

bcl-2; apoptosis regulator
NM_001289717.2 → NP_001276646.1 bcl-2-like protein 1 isoform a

See identical proteins and their annotated locations for NP_001276646.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. Variants 1, 2, 3, and 5 all encode the same isoform (a, also known as Bcl-xL; PMID 7607090).

Source sequence(s)

AL731857

Consensus CDS

CCDS16899.1

UniProtKB/Swiss-Prot

O35844, Q60657, Q60658, Q61338, Q64373

UniProtKB/TrEMBL

Q3T9W4, Q5HZH3

Conserved Domains (1) summary

TIGR00865
Location:1 → 233

bcl-2; apoptosis regulator
NM_001289739.2 → NP_001276668.1 bcl-2-like protein 1 isoform b

See identical proteins and their annotated locations for NP_001276668.1

Status: REVIEWED

Source sequence(s)

AL731857

UniProtKB/TrEMBL

O35843, Q99N36

Conserved Domains (3) summary

smart00265
Location:1 → 27

BH4; BH4 Bcl-2 homology region 4

cd06845
Location:81 → 188

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 188

bcl-2; apoptosis regulator
NM_001355053.2 → NP_001341982.1 bcl-2-like protein 1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (5) represents the longest transcript and encodes the shorter isoform (a, also known as Bcl-xL; PMID 7607090). Variants 1, 2, 3, and 5 all encode the same isoform (a).

Source sequence(s)

AL731857

Consensus CDS

CCDS16899.1

UniProtKB/Swiss-Prot

O35844, Q60657, Q60658, Q61338, Q64373

UniProtKB/TrEMBL

Q3T9W4, Q5HZH3

Conserved Domains (1) summary

TIGR00865
Location:1 → 233

bcl-2; apoptosis regulator
NM_001416896.1 → NP_001403825.1 bcl-2-like protein 1 isoform a

Status: REVIEWED

Source sequence(s)

AL731857

UniProtKB/Swiss-Prot

O35844, Q60657, Q60658, Q61338, Q64373

UniProtKB/TrEMBL

Q5HZH3
NM_001416897.1 → NP_001403826.1 bcl-2-like protein 1 isoform a

Status: REVIEWED

Source sequence(s)

AL731857

UniProtKB/Swiss-Prot

O35844, Q60657, Q60658, Q61338, Q64373

UniProtKB/TrEMBL

Q5HZH3
NM_001416898.1 → NP_001403827.1 bcl-2-like protein 1 isoform a

Status: REVIEWED

Source sequence(s)

AL731857

UniProtKB/Swiss-Prot

O35844, Q60657, Q60658, Q61338, Q64373

UniProtKB/TrEMBL

Q5HZH3
NM_001416899.1 → NP_001403828.1 bcl-2-like protein 1 isoform a

Status: REVIEWED

Source sequence(s)

AL731857

UniProtKB/Swiss-Prot

O35844, Q60657, Q60658, Q61338, Q64373

UniProtKB/TrEMBL

Q5HZH3
NM_009743.6 → NP_033873.3 bcl-2-like protein 1 isoform a

See identical proteins and their annotated locations for NP_033873.3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 1, 2, 3, and 5 all encode the same isoform (a, also known as Bcl-xL; PMID 7607090).

Source sequence(s)

AL731857

Consensus CDS

CCDS16899.1

UniProtKB/Swiss-Prot

O35844, Q60657, Q60658, Q61338, Q64373

UniProtKB/TrEMBL

Q3T9W4, Q5HZH3

Related

ENSMUSP00000007803.6, ENSMUST00000007803.12

Conserved Domains (1) summary

TIGR00865
Location:1 → 233

bcl-2; apoptosis regulator

RNA

NR_149254.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' end compared to variant 5. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 5.

Source sequence(s)

AL731857