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    Slc39a9 solute carrier family 39 (zinc transporter), member 9 [ Mus musculus (house mouse) ]

    Gene ID: 328133, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slc39a9provided by MGI
    Official Full Name
    solute carrier family 39 (zinc transporter), member 9provided by MGI
    Primary source
    MGI:MGI:1914820
    See related
    Ensembl:ENSMUSG00000048833 AllianceGenome:MGI:1914820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010002A02Rik; 2610511I23Rik; 4833420E20Rik
    Summary
    Predicted to enable metal ion transmembrane transporter activity. Predicted to be involved in metal ion transport and transmembrane transport. Predicted to act upstream of or within zinc ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human SLC39A9 (solute carrier family 39 member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 22.7), colon adult (RPKM 21.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc39a9 in Genome Data Viewer
    Location:
    12 C3; 12 36.91 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80690657..80730116)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80643883..80683342)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32644 Neighboring gene predicted gene, 23817 Neighboring gene STARR-positive B cell enhancer ABC_E4032 Neighboring gene ERH mRNA splicing and mitosis factor Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1, opposite strand Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 Neighboring gene predicted gene, 51986

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice. Song L, et al. Front Endocrinol (Lausanne), 2023. PMID 37305050, Free PMC Article
    2. Non-classical testosterone signaling in spermatogenic GC-2 cells is mediated through ZIP9 interacting with Gnα11. Shihan M, et al. Cell Signal, 2015 Oct. PMID 26208885
    3. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice.
      Title: ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice.
    2. ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells.
      Title: Non-classical testosterone signaling in spermatogenic GC-2 cells is mediated through ZIP9 interacting with Gnα11.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androgen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular response to testosterone stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc transporter ZIP9
    Names
    ZIP-9
    solute carrier family 39 member 9
    zrt- and Irt-like protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026244.2 → NP_080520.2  zinc transporter ZIP9

      See identical proteins and their annotated locations for NP_080520.2

      Status: VALIDATED

      Source sequence(s)
      BC058649, BC072655, BY148507, CO040789
      Consensus CDS
      CCDS49099.1
      UniProtKB/Swiss-Prot
      B2RY14, Q8BFU1
      UniProtKB/TrEMBL
      A0A1W2P6Y1
      Related
      ENSMUSP00000082343.6, ENSMUST00000085245.7
      Conserved Domains (1) summary
      pfam02535
      Location:9 → 302
      Zip; ZIP Zinc transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      80690657..80730116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516033.4 → XP_006516096.1  zinc transporter ZIP9 isoform X3

      Conserved Domains (1) summary
      cl00437
      Location:9 → 144
      Zip; ZIP Zinc transporter

    2. XM_017315121.3 → XP_017170610.1  zinc transporter ZIP9 isoform X1

      UniProtKB/Swiss-Prot
      B2RY14, Q8BFU1
      UniProtKB/TrEMBL
      A0A1W2P6Y1
      Conserved Domains (1) summary
      pfam02535
      Location:9 → 302
      Zip; ZIP Zinc transporter

    3. XM_006516032.4 → XP_006516095.1  zinc transporter ZIP9 isoform X2

      Conserved Domains (1) summary
      cl00437
      Location:56 → 226
      Zip; ZIP Zinc transporter

    4. XM_006516034.5 → XP_006516097.1  zinc transporter ZIP9 isoform X4

      Conserved Domains (1) summary
      pfam02535
      Location:9 → 278
      Zip; ZIP Zinc transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFU1.1 GenPept UniProtKB/Swiss-Prot:Q8BFU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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