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    Ak4 adenylate kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 11639, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ak4provided by MGI
    Official Full Name
    adenylate kinase 4provided by MGI
    Primary source
    MGI:MGI:87979
    See related
    Ensembl:ENSMUSG00000028527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ak-; Ak3; AK 4; Ak-3; Ak-4; Ak3l1; D4Ertd274; D4Ertd274e
    Expression
    Biased expression in kidney adult (RPKM 34.8), cerebellum adult (RPKM 9.7) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Ak4 in Genome Data Viewer
    Location:
    4 C6; 4 46.84 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101273675..101324968)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101416478..101467771)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (101091894..101140376)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130102H24 gene Neighboring gene RIKEN cDNA 0610043K17 gene Neighboring gene microRNA 101a Neighboring gene ribosomal protein L9 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene predicted gene, 36012 Neighboring gene leptin receptor overlapping transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleobase-containing compound kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside triphosphate adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotransferase activity, phosphate group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in AMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in AMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleoside diphosphate phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleoside diphosphate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleoside triphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nucleoside triphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adenylate kinase 4, mitochondrial
    Names
    ATP-AMP transphosphorylase
    GTP:AMP phosphotransferase AK4, mitochondrial
    adenylate kinase 3 alpha-like 1
    adenylate kinase 3-like 1
    adenylate kinase isoenzyme 4, mitochondrial
    NP_001171073.1
    NP_001171075.1
    NP_001171076.1
    NP_033777.1
    XP_006502748.1
    XP_017175412.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177602.1NP_001171073.1  adenylate kinase 4, mitochondrial

      See identical proteins and their annotated locations for NP_001171073.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK004491, AL845364, AV023306, BC086663, BY718404
      Consensus CDS
      CCDS18394.1
      UniProtKB/Swiss-Prot
      Q9WUR9
      UniProtKB/TrEMBL
      Q3U489
      Related
      ENSMUSP00000102559.2, ENSMUST00000106946.8
      Conserved Domains (1) summary
      TIGR01351
      Location:7211
      adk; adenylate kinase
    2. NM_001177604.1NP_001171075.1  adenylate kinase 4, mitochondrial

      See identical proteins and their annotated locations for NP_001171075.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK004491, AL845364, AV023306, BC086663, BY203078
      Consensus CDS
      CCDS18394.1
      UniProtKB/Swiss-Prot
      Q9WUR9
      UniProtKB/TrEMBL
      Q3U489
      Related
      ENSMUSP00000102558.2, ENSMUST00000106945.8
      Conserved Domains (1) summary
      TIGR01351
      Location:7211
      adk; adenylate kinase
    3. NM_001177605.1NP_001171076.1  adenylate kinase 4, mitochondrial

      See identical proteins and their annotated locations for NP_001171076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK004491, AL845364, AV023306, BC086663, BY740484
      Consensus CDS
      CCDS18394.1
      UniProtKB/Swiss-Prot
      Q9WUR9
      UniProtKB/TrEMBL
      Q3U489
      Related
      ENSMUSP00000099841.2, ENSMUST00000102780.8
      Conserved Domains (1) summary
      TIGR01351
      Location:7211
      adk; adenylate kinase
    4. NM_009647.5NP_033777.1  adenylate kinase 4, mitochondrial

      See identical proteins and their annotated locations for NP_033777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK004491, AL845364, AV023306, BC086663, CJ087385
      Consensus CDS
      CCDS18394.1
      UniProtKB/Swiss-Prot
      Q9WUR9
      UniProtKB/TrEMBL
      Q3U489
      Conserved Domains (1) summary
      TIGR01351
      Location:7211
      adk; adenylate kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      101273675..101324968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319923.2XP_017175412.1  adenylate kinase 4, mitochondrial isoform X1

      Conserved Domains (1) summary
      TIGR01351
      Location:7171
      adk; adenylate kinase
    2. XM_006502685.3XP_006502748.1  adenylate kinase 4, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006502748.1

      Related
      ENSMUSP00000121112.2, ENSMUST00000155749.2
      Conserved Domains (1) summary
      TIGR01351
      Location:1139
      adk; adenylate kinase
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