Akap7 A kinase anchor protein 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akap7provided by MGI
Official Full Name: A kinase anchor protein 7provided by MGI
Primary source: MGI:MGI:1859150
See related: Ensembl:ENSMUSG00000039166 AllianceGenome:MGI:1859150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AKAP15; Akap18; 6430401D08
Summary: Enables protein kinase A regulatory subunit binding activity and protein kinase binding activity. Involved in modulation of chemical synaptic transmission. Located in cytoplasm; hippocampal mossy fiber to CA3 synapse; and nucleus. Is expressed in several structures, including cartilage; endocrine gland; genitourinary system; telencephalon; and trachea. Orthologous to human AKAP7 (A-kinase anchoring protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 6.0), CNS E18 (RPKM 4.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 12.26 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (25044988..25175115, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (25169090..25299217, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Requirement of the Ca(2+) channel beta2 subunit for sympathetic PKA phosphorylation.
Title: Requirement of the Ca(2+) channel β(2) subunit for sympathetic PKA phosphorylation.
Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of mossy fiber-CA3 pyramidal neuron long-term potentiation directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. The results suggest that the AKAP7/PKA complex in the mossy fiber projections plays an essential role in synaptic plasticity and contextual memory formation.
Title: Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.
The results demonstrate that green tea catechins enhance lipolysis in the presence of norepinephrine via a PKA-dependent pathway in 3T3-L1 adipocytes, providing a potential mechanism by which green tea catechins could reduce body fat.
Title: Green tea catechins enhance norepinephrine-induced lipolysis via a protein kinase A-dependent pathway in adipocytes.
Protein kinase A activation enhances hippocampal mossy fiber glutamatergic transmission.
Title: Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation.
AKAP7 is not required for regulation of Ca(2+) handling in mouse cardiomyocytes.
Title: Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.
AKAP15 co-immunoprecipitates with CaV1.2 and CaV1.3 channels. AKAP15 has overlapping localization with CaV1.2 and CaV1.3 channels in cell bodies and proximal dendrites and is closely co-localized with CaV1.2 channels in punctate clusters.
Title: Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons.
CaV1.2 channels in DCT-/- myocytes fail to respond to activation of adenylyl cyclase by forskolin, and the localized expression of AKAP15 is reduced
Title: Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.
Alterations in cortical synaptic receptors, impairments in sleep continuity, and alterations in sleep oscillations in R(AB) mice imply that PKA is involved not only in synaptic plasticity and memory storage but also in the regulation of sleep/wake states.
Title: Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations.
AKAP7gamma is the first nuclear AKAP to bind RI and may be responsible for positioning PKA via RI and/or RII to regulate PKA-mediated gene transcription in both somatic cells and oocytes
Title: AKAP7gamma is a nuclear RI-binding AKAP.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI662165 (e-PCR)
- UniSTS:164431

BB170514 (e-PCR)
- UniSTS:185819

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AMP binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A regulatory subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase anchor protein 7

Names: A kinase (PRKA) anchor protein 7; A-kinase anchor protein 18; A-kinase anchor protein 9 kDa; AKAP 9; AKAP-18; protein kinase A anchoring protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347460.2 → NP_001334389.1 A-kinase anchor protein 7 isoform 2

Status: VALIDATED

Source sequence(s)

AC153549

Consensus CDS

CCDS83688.1

UniProtKB/Swiss-Prot

G3X9Q5, O55074

Related

ENSMUSP00000097590.3, ENSMUST00000100012.3

Conserved Domains (1) summary

pfam10470
Location:23 → 79

AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
NM_001379238.1 → NP_001366167.1 A-kinase anchor protein 7 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.

Source sequence(s)

AC153549, AC153550

UniProtKB/Swiss-Prot

F8VQ58, Q7TN79

Conserved Domains (2) summary

pfam10470
Location:256 → 311

AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein

pfam10469
Location:51 → 249

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
NM_001379239.1 → NP_001366168.1 A-kinase anchor protein 7 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (3).

Source sequence(s)

AC153549, AC153550

Conserved Domains (1) summary

pfam10469
Location:51 → 249

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
NM_001379240.1 → NP_001366169.1 A-kinase anchor protein 7 isoform 4

Status: VALIDATED

Source sequence(s)

AC153550

UniProtKB/TrEMBL

Q4KL21

Related

ENSMUSP00000093455.5, ENSMUST00000095779.11
NM_018747.5 → NP_061217.3 A-kinase anchor protein 7 isoform 1

See identical proteins and their annotated locations for NP_061217.3

Status: VALIDATED

Description

Transcript Variant: This variant (1), as well as variant 3, encodes isoform 1.

Source sequence(s)

AC153549, AC153550

Consensus CDS

CCDS23753.1

UniProtKB/Swiss-Prot

F8VQ58, Q7TN79

Related

ENSMUSP00000043624.8, ENSMUST00000041984.14

Conserved Domains (2) summary

pfam10470
Location:256 → 311

AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein

pfam10469
Location:51 → 249

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

RNA

NR_166567.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153549, AC153550
NR_166568.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153549, AC153550
NR_166569.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153549

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

25044988..25175115 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512788.4 → XP_006512851.1 A-kinase anchor protein 7 isoform X2

See identical proteins and their annotated locations for XP_006512851.1

Conserved Domains (1) summary

pfam10469
Location:51 → 249

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_030245157.2 → XP_030101017.1 A-kinase anchor protein 7 isoform X3

UniProtKB/Swiss-Prot

F8VQ58, Q7TN79

Conserved Domains (2) summary

pfam10470
Location:256 → 311

AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein

pfam10469
Location:51 → 249

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_030245156.1 → XP_030101016.1 A-kinase anchor protein 7 isoform X2

Conserved Domains (1) summary

pfam10469
Location:51 → 249

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_006512790.3 → XP_006512853.1 A-kinase anchor protein 7 isoform X2

See identical proteins and their annotated locations for XP_006512853.1

Conserved Domains (1) summary

pfam10469
Location:51 → 249

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_036155887.1 → XP_036011780.1 A-kinase anchor protein 7 isoform X2

Conserved Domains (1) summary

pfam10469
Location:51 → 249

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_006512789.2 → XP_006512852.1 A-kinase anchor protein 7 isoform X2

See identical proteins and their annotated locations for XP_006512852.1

Conserved Domains (1) summary

pfam10469
Location:51 → 249

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_006512791.5 → XP_006512854.1 A-kinase anchor protein 7 isoform X2

See identical proteins and their annotated locations for XP_006512854.1

Conserved Domains (1) summary

pfam10469
Location:51 → 249

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_006512793.5 → XP_006512856.1 A-kinase anchor protein 7 isoform X4

See identical proteins and their annotated locations for XP_006512856.1

Conserved Domains (1) summary

pfam10469
Location:6 → 164

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_006512794.5 → XP_006512857.1 A-kinase anchor protein 7 isoform X4

See identical proteins and their annotated locations for XP_006512857.1

Conserved Domains (1) summary

pfam10469
Location:6 → 164

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_017314023.3 → XP_017169512.1 A-kinase anchor protein 7 isoform X5

Conserved Domains (1) summary

pfam10470
Location:46 → 102

AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
XM_036155886.1 → XP_036011779.1 A-kinase anchor protein 7 isoform X1

Conserved Domains (1) summary

pfam10469
Location:187 → 385

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain