Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Entpd1provided by MGI
Official Full Name: ectonucleoside triphosphate diphosphohydrolase 1provided by MGI
Primary source: MGI:MGI:102805
See related: Ensembl:ENSMUSG00000048120 AllianceGenome:MGI:102805
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd39; ATP-DPH; NTPDase-1; 2610206B08Rik; E130009M23Rik
Summary: Enables adenosine-diphosphatase activity and nucleoside-triphosphatase activity. Involved in ADP catabolic process. Acts upstream of or within G protein-coupled receptor signaling pathway; platelet activation; and purine ribonucleoside diphosphate catabolic process. Located in basement membrane. Is active in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 23.6), placenta adult (RPKM 14.5) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 34.25 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (40600810..40730046)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (40612366..40741602)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immune cell expression patterns of CD39/CD73 ectonucleotidases in rodent models of cardiac arrest and resuscitation.
Title: Immune cell expression patterns of CD39/CD73 ectonucleotidases in rodent models of cardiac arrest and resuscitation.
NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow.
Title: NTPDase1/CD39 Ectonucleotidase Is Necessary for Normal Arterial Diameter Adaptation to Flow.
Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39.
Title: Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39.
The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39.
Title: The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39.
Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8(+) T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation.
Title: Inhibitory Molecules PD-1, CD73 and CD39 Are Expressed by CD8(+) T Cells in a Tissue-Dependent Manner and Can Inhibit T Cell Responses to Stimulation.
CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
Title: CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease.
CD39/CD73/A2a Adenosine Metabolic Pathway: Targets for Moxibustion in Treating DSS-Induced Ulcerative Colitis.
Title: CD39/CD73/A2a Adenosine Metabolic Pathway: Targets for Moxibustion in Treating DSS-Induced Ulcerative Colitis.
NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female.
Title: NTPDase1 Modulates Smooth Muscle Contraction in Mice Bladder by Regulating Nucleotide Receptor Activation Distinctly in Male and Female.
CD39 Produced from Human GMSCs Regulates the Balance of Osteoclasts and Osteoblasts through the Wnt/beta-Catenin Pathway in Osteoporosis.
Title: CD39 Produced from Human GMSCs Regulates the Balance of Osteoclasts and Osteoblasts through the Wnt/β-Catenin Pathway in Osteoporosis.
Mechanism of Graft Damage Caused by NTPDase1-activated Macrophages in Acute Antibody-Mediated Rejection.
Title: Mechanism of Graft Damage Caused by NTPDase1-activated Macrophages in Acute Antibody-Mediated Rejection.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Endonuclease-mediated (7)

General gene information

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Markers

RH124743 (e-PCR)
- UniSTS:161565

RH126699 (e-PCR)
- UniSTS:209466

Entpd1 (e-PCR), detects polymorphism
- UniSTS:546757

AF037366 (e-PCR)
- UniSTS:181241

RH125812 (e-PCR)
- UniSTS:162558

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ADP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables apyrase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nucleoside diphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoside triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside triphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoside triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ADP catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dopamine secretion	ISO Inferred from Sequence Orthology more info
involved_in nucleoside diphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within platelet activation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within purine ribonucleoside diphosphate catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ectonucleoside triphosphate diphosphohydrolase 1

Names: ATP diphosphohydrolase; ATPDase; CD39 antigen; NTPDase 1; NTPDase1; ecto-ATP diphosphohydrolase 1; ecto-ATPDase 1; ecto-ATPase 1; ectoapyrase; lymphoid cell activation antigen; nucleoside triphosphate diphosphohydrolase 1

NP_001291650.1

EC 3.6.1.5

NP_033978.1

EC 3.6.1.5

XP_006526681.1

EC 3.6.1.5

XP_006526682.1

EC 3.6.1.5

XP_006526683.1

EC 3.6.1.5

XP_017173536.1

EC 3.6.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001304721.1 → NP_001291650.1 ectonucleoside triphosphate diphosphohydrolase 1 isoform 1

See identical proteins and their annotated locations for NP_001291650.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC166063, AK029512, AK030601

Consensus CDS

CCDS79708.1

UniProtKB/TrEMBL

Q8CDV7, Q921Q6

Related

ENSMUSP00000116285.2, ENSMUST00000134063.8

Conserved Domains (1) summary

pfam01150
Location:69 → 500

GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
NM_009848.4 → NP_033978.1 ectonucleoside triphosphate diphosphohydrolase 1 isoform 2

See identical proteins and their annotated locations for NP_033978.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses an alternate start codon, compared to variant 1. It encodes isoform 2 which has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK030601, CN696192

Consensus CDS

CCDS50434.1

UniProtKB/Swiss-Prot

P55772

UniProtKB/TrEMBL

Q544U5, Q921Q6

Related

ENSMUSP00000107850.3, ENSMUST00000112231.9

Conserved Domains (1) summary

pfam01150
Location:40 → 471

GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

40600810..40730046

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526619.5 → XP_006526682.1 ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

See identical proteins and their annotated locations for XP_006526682.1

UniProtKB/TrEMBL

Q8CEB1

Conserved Domains (1) summary

cl17037
Location:1 → 363

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
XM_006526620.5 → XP_006526683.1 ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

See identical proteins and their annotated locations for XP_006526683.1

UniProtKB/TrEMBL

Q8CEB1

Conserved Domains (1) summary

cl17037
Location:1 → 363

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
XM_006526618.5 → XP_006526681.1 ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

See identical proteins and their annotated locations for XP_006526681.1

UniProtKB/TrEMBL

Q8CEB1

Conserved Domains (1) summary

cl17037
Location:1 → 363

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
XM_017318047.2 → XP_017173536.1 ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

UniProtKB/TrEMBL

Q8CEB1

Conserved Domains (1) summary

cl17037
Location:1 → 363

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily