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    Isca2 iron-sulfur cluster assembly 2 [ Mus musculus (house mouse) ]

    Gene ID: 74316, updated on 11-Apr-2024

    Summary

    Official Symbol
    Isca2provided by MGI
    Official Full Name
    iron-sulfur cluster assembly 2provided by MGI
    Primary source
    MGI:MGI:1921566
    See related
    Ensembl:ENSMUSG00000021241 AllianceGenome:MGI:1921566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hbld1; 0710001C05Rik; 5730594E03Rik
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Located in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Orthologous to human ISCA2 (iron-sulfur cluster assembly 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 27.8), liver E14.5 (RPKM 25.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Isca2 in Genome Data Viewer
    Location:
    12 D1; 12 39.38 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84820007..84821863)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84773230..84775089)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene synapse differentiation inducing 1 like Neighboring gene STARR-positive B cell enhancer mm9_chr12:86096267-86096568 Neighboring gene NPC intracellular cholesterol transporter 2 Neighboring gene latent transforming growth factor beta binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_32756 Neighboring gene STARR-seq mESC enhancer starr_32757 Neighboring gene RIKEN cDNA D030025P21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7160 Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86311736-86311923

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein maturation by [4Fe-4S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    iron-sulfur cluster assembly 2 homolog, mitochondrial
    Names
    HESB like domain containing 1
    HESB-like domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028863.1NP_083139.1  iron-sulfur cluster assembly 2 homolog, mitochondrial precursor

      See identical proteins and their annotated locations for NP_083139.1

      Status: VALIDATED

      Source sequence(s)
      AK002936, BY125913, BY577917
      Consensus CDS
      CCDS49111.1
      UniProtKB/Swiss-Prot
      Q9DCB8
      UniProtKB/TrEMBL
      A0A1Y7VK19
      Related
      ENSMUSP00000021667.6, ENSMUST00000021667.7
      Conserved Domains (1) summary
      cl00400
      Location:1153
      Fe-S_biosyn; Iron-sulphur cluster biosynthesis

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84820007..84821863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516297.5XP_006516360.1  iron-sulfur cluster assembly 2 homolog, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VK19
      Conserved Domains (1) summary
      cl00400
      Location:24137
      Fe-S_biosyn; Iron-sulphur cluster biosynthesis
    2. XM_006516298.3XP_006516361.1  iron-sulfur cluster assembly 2 homolog, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A1Y7VK19
      Conserved Domains (1) summary
      cl00400
      Location:17130
      Fe-S_biosyn; Iron-sulphur cluster biosynthesis
    3. XM_006516296.4XP_006516359.1  iron-sulfur cluster assembly 2 homolog, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VK19
      Related
      ENSMUSP00000152679.2, ENSMUST00000222982.2
      Conserved Domains (1) summary
      cl00400
      Location:33146
      Fe-S_biosyn; Iron-sulphur cluster biosynthesis