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    Nup93 nucleoporin 93 [ Mus musculus (house mouse) ]

    Gene ID: 71805, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Nup93provided by MGI
    Official Full Name
    nucleoporin 93provided by MGI
    Primary source
    MGI:MGI:1919055
    See related
    Ensembl:ENSMUSG00000032939 AllianceGenome:MGI:1919055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410008G02Rik
    Summary
    Predicted to be a structural constituent of nuclear pore. Involved in SMAD protein signal transduction and positive regulation of SMAD protein signal transduction. Located in centrosome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 12. Orthologous to human NUP93 (nucleoporin 93). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.5), limb E14.5 (RPKM 14.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nup93 in Genome Data Viewer
    Location:
    8 C5; 8 46.4 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94941203..95043858)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94214564..94328100)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:96707225-96707334 Neighboring gene uncharacterized LOC118567560 Neighboring gene metallothionein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3793 Neighboring gene ribosomal protein L10, pseudogene 5 Neighboring gene microRNA 138-2 Neighboring gene solute carrier family 12, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E8256 Neighboring gene STARR-positive B cell enhancer ABC_E3794

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses. Monwan W, et al. Biochem Biophys Res Commun, 2020 Jan 22. PMID 31733835
    2. The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice. Beckers A, et al. Sci Rep, 2018 Oct 2. PMID 30279523, Free PMC Article
    3. Functional interaction of CREB binding protein (CBP) with nuclear transport proteins and modulation by HDAC inhibitors. Ryan CM, et al. Cell Cycle, 2006 Sep. PMID 16969114
    4. Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. Braun DA, et al. Nat Genet, 2016 Apr. PMID 26878725, Free PMC Article
    5. TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination. Li W, et al. Cell Commun Signal, 2019 Dec 10. PMID 31823782, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nup93 regulates antiviral innate immunity by enhancing TBK1 activity and IRF3 nuclear translocation.
      Title: Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup93
    Names
    93 kDa nucleoporin
    CBP-interacting protein 4
    nucleoporin Nup93

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357266.2 → NP_001344195.1  nuclear pore complex protein Nup93 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733
      Consensus CDS
      CCDS22540.1
      UniProtKB/Swiss-Prot
      Q3TED9, Q8BIK7, Q8BJ71, Q8K1R4, Q8R592
      UniProtKB/TrEMBL
      Q3TFC8
      Related
      ENSMUSP00000078878.7, ENSMUST00000079961.14
      Conserved Domains (1) summary
      pfam04097
      Location:220 → 802
      Nic96; Nup93/Nic96

    2. NM_001357267.2 → NP_001344196.1  nuclear pore complex protein Nup93 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733
      UniProtKB/TrEMBL
      Q3TFC8
      Conserved Domains (1) summary
      pfam04097
      Location:97 → 679
      Nic96; Nup93/Nic96

    3. NM_001357268.2 → NP_001344197.1  nuclear pore complex protein Nup93 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733
      Consensus CDS
      CCDS90438.1
      UniProtKB/TrEMBL
      A0A1D5RLQ0, Q3TFC8
      Related
      ENSMUSP00000148458.2, ENSMUST00000211822.2
      Conserved Domains (1) summary
      pfam04097
      Location:97 → 679
      Nic96; Nup93/Nic96

    4. NM_001424438.1 → NP_001411367.1  nuclear pore complex protein Nup93 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733

    5. NM_001424439.1 → NP_001411368.1  nuclear pore complex protein Nup93 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733

    6. NM_001424440.1 → NP_001411369.1  nuclear pore complex protein Nup93 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733

    7. NM_001424441.1 → NP_001411370.1  nuclear pore complex protein Nup93 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733

    8. NM_001424442.1 → NP_001411371.1  nuclear pore complex protein Nup93 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733

    9. NM_001424443.1 → NP_001411372.1  nuclear pore complex protein Nup93 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733

    10. NM_001424444.1 → NP_001411373.1  nuclear pore complex protein Nup93 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733

    11. NM_001424445.1 → NP_001411374.1  nuclear pore complex protein Nup93 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733

    12. NM_001424446.1 → NP_001411375.1  nuclear pore complex protein Nup93 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733

    13. NM_001424447.1 → NP_001411376.1  nuclear pore complex protein Nup93 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733

    14. NM_172410.4 → NP_765998.1  nuclear pore complex protein Nup93 isoform 1

      See identical proteins and their annotated locations for NP_765998.1

      Status: VALIDATED

      Source sequence(s)
      AC128663, AC131733
      Consensus CDS
      CCDS22540.1
      UniProtKB/Swiss-Prot
      Q3TED9, Q8BIK7, Q8BJ71, Q8K1R4, Q8R592
      UniProtKB/TrEMBL
      Q3TFC8
      Related
      ENSMUSP00000148700.2, ENSMUST00000212824.2
      Conserved Domains (1) summary
      pfam04097
      Location:220 → 802
      Nic96; Nup93/Nic96

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      94941203..95043858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJ71.1 GenPept UniProtKB/Swiss-Prot:Q8BJ71

    Gene LinkOut

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