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    Uck1 uridine-cytidine kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 22245, updated on 23-Jun-2021

    Summary

    Official Symbol
    Uck1provided by MGI
    Official Full Name
    uridine-cytidine kinase 1provided by MGI
    Primary source
    MGI:MGI:98904
    See related
    Ensembl:ENSMUSG00000002550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    URK; URK1; Umpk
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 75.9), adrenal adult (RPKM 70.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Uck1 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32145014..32150117, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32255002..32260105, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32110522..32115625, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2B Neighboring gene predicted gene, 22192 Neighboring gene predicted gene, 25632 Neighboring gene protein-O-mannosyltransferase 1 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene SWI5 recombination repair homolog (yeast)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleoside kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables uridine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    uridine-cytidine kinase 1
    Names
    UCK 1
    cytidine monophosphokinase 1
    uridine monophosphate kinase
    uridine monophosphokinase 1
    NP_001365720.1
    NP_001365721.1
    NP_035805.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378791.1NP_001365720.1  uridine-cytidine kinase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL808027
      Conserved Domains (1) summary
      cd02023
      Location:31254
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    2. NM_001378792.1NP_001365721.1  uridine-cytidine kinase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL808027
      Conserved Domains (1) summary
      cd02023
      Location:12187
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
    3. NM_011675.2NP_035805.2  uridine-cytidine kinase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK132100, BY338721, CJ194826, L31783
      Consensus CDS
      CCDS15909.2
      UniProtKB/Swiss-Prot
      P52623
      UniProtKB/TrEMBL
      A2AN37, Q3V218
      Related
      ENSMUSP00000002625.9, ENSMUST00000002625.15
      Conserved Domains (2) summary
      COG0572
      Location:24238
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:31236
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32145014..32150117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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