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    Mib2 mindbomb E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

    Gene ID: 76580, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Mib2provided by MGI
    Official Full Name
    mindbomb E3 ubiquitin protein ligase 2provided by MGI
    Primary source
    MGI:MGI:2679684
    See related
    Ensembl:ENSMUSG00000029060 AllianceGenome:MGI:2679684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    skd; Zzank1; 2210008I11Rik
    Summary
    Enables ubiquitin protein ligase activity. Acts upstream of or within protein ubiquitination. Located in early endosome. Part of ubiquitin ligase complex. Is expressed in several structures, including 4th ventricle choroid plexus; genitourinary system; gut; hair follicle; and hemolymphoid system gland. Orthologous to human MIB2 (MIB E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 36.2), adrenal adult (RPKM 23.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 E2; 4 86.86 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155738925..155753711, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155654468..155669254, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene cyclin dependent kinase 11B Neighboring gene matrix metallopeptidase 23 Neighboring gene STARR-seq mESC enhancer starr_12269 Neighboring gene STARR-seq mESC enhancer starr_12270 Neighboring gene STARR-seq mESC enhancer starr_12271 Neighboring gene STARR-positive B cell enhancer ABC_E6297 Neighboring gene fibronectin type III domain containing 10 Neighboring gene STARR-seq mESC enhancer starr_12272 Neighboring gene Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) Neighboring gene predicted gene, 22573

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity. Kim S, et al. Korean J Physiol Pharmacol, 2015 Nov. PMID 26557018, Free PMC Article
    2. PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination. Yu X, et al. J Clin Invest, 2023 Feb 1. PMID 36719382, Free PMC Article
    3. Participation of Mind Bomb-2 in Sevoflurane Anesthesia Induces Cognitive Impairment in Aged Mice via Modulating Ferroptosis. Zhao L, et al. ACS Chem Neurosci, 2021 Jul 7. PMID 34121396
    4. Targeted disruption of Mib2 causes exencephaly with a variable penetrance. Wu JI, et al. Genesis, 2007 Nov. PMID 17987667
    5. Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2. Li R, et al. Nat Commun, 2023 Apr 8. PMID 37031213, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.
      Title: PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.
    2. identify MIB2 as a novel component of the activated BCL10 signaling complex and a missing link in the BCL10-dependent NF-kappaB signaling pathway.
      Title: The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation.
    3. created a targeted mutation of Mib2 and show that its phenotype is a variable penetrance, failure to close the cranial neural tube
      Title: Targeted disruption of Mib2 causes exencephaly with a variable penetrance.
    4. Mib2 has functional similarities to Mib1, but might have distinct roles in Notch signaling as an E3 ubiquitin ligase
      Title: Mind bomb-2 is an E3 ligase for Notch ligand.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MIB2
    Names
    RING-type E3 ubiquitin transferase MIB2
    dyslike
    dystrophin-like protein
    mind bomb-2
    mindbomb homolog 2
    skeletrophin
    zinc finger, ZZ type with ankyrin repeat domain 1
    NP_001243036.1
    NP_001243037.2
    NP_001356090.1
    NP_001356091.1
    NP_001356092.1
    NP_001356093.1
    NP_001356094.1
    NP_001356095.1
    NP_001356096.1
    NP_001356097.1
    NP_660106.2
    XP_006539310.1
    XP_006539312.1
    XP_006539314.1
    XP_006539317.1
    XP_006539318.1
    XP_011248655.1
    XP_017175926.1
    XP_030109739.1
    XP_030109740.1
    XP_030109741.1
    XP_030109742.1
    XP_030109743.1
    XP_036020422.1
    XP_036020423.1
    XP_036020424.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256107.1 → NP_001243036.1  E3 ubiquitin-protein ligase MIB2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variant 4, encodes isoform 1.
      Source sequence(s)
      AI837194, AK147940, AK159611, CJ076202
      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:424 → 488
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:457 → 708
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:461 → 491
      ANK; ANK repeat [structural motif]
      cd00162
      Location:909 → 941
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:829 → 865
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:324 → 388
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:908 → 953
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001256108.2 → NP_001243037.2  E3 ubiquitin-protein ligase MIB2 isoform 2

      See identical proteins and their annotated locations for NP_001243037.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 2, 3, 5, and 6 all encode the same isoform (2).
      Source sequence(s)
      AI837194, AK147940, AK159611, CJ076202
      Consensus CDS
      CCDS19035.1
      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (7) summary
      PLN03192
      Location:392 → 456
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:425 → 676
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:429 → 459
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      cd16726
      Location:797 → 833
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      cl17238
      Location:876 → 921
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. NM_001369161.1 → NP_001356090.1  E3 ubiquitin-protein ligase MIB2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AL627405
      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:424 → 488
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:457 → 708
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:461 → 491
      ANK; ANK repeat [structural motif]
      cd00162
      Location:909 → 941
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:829 → 865
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:324 → 388
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:908 → 953
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. NM_001369162.1 → NP_001356091.1  E3 ubiquitin-protein ligase MIB2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 2, 3, and 6, encodes isoform 2.
      Source sequence(s)
      AL627405
      Consensus CDS
      CCDS19035.1
      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (7) summary
      PLN03192
      Location:392 → 456
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:425 → 676
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:429 → 459
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      cd16726
      Location:797 → 833
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      cl17238
      Location:876 → 921
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    5. NM_001369163.1 → NP_001356092.1  E3 ubiquitin-protein ligase MIB2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 2, 3, and 5, encodes isoform 2.
      Source sequence(s)
      AL627405
      Consensus CDS
      CCDS19035.1
      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (7) summary
      PLN03192
      Location:392 → 456
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:425 → 676
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:429 → 459
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      cd16726
      Location:797 → 833
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      cl17238
      Location:876 → 921
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    6. NM_001369164.1 → NP_001356093.1  E3 ubiquitin-protein ligase MIB2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes the longest isoform (3).
      Source sequence(s)
      AL627405
      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:428 → 492
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:461 → 712
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:465 → 495
      ANK; ANK repeat [structural motif]
      cd00162
      Location:913 → 945
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:833 → 869
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:912 → 957
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    7. NM_001369165.1 → NP_001356094.1  E3 ubiquitin-protein ligase MIB2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes the longest isoform (3).
      Source sequence(s)
      AL627405
      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:428 → 492
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:461 → 712
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:465 → 495
      ANK; ANK repeat [structural motif]
      cd00162
      Location:913 → 945
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:833 → 869
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:912 → 957
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    8. NM_001369166.1 → NP_001356095.1  E3 ubiquitin-protein ligase MIB2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627405
      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (8) summary
      PLN03192
      Location:323 → 387
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:356 → 607
      PHA03095; ankyrin-like protein; Provisional
      pfam10921
      Location:154 → 232
      DUF2710; Protein of unknown function (DUF2710)
      sd00045
      Location:360 → 390
      ANK; ANK repeat [structural motif]
      cl00295
      Location:1 → 32
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      pfam06701
      Location:59 → 123
      MIB_HERC2; Mib_herc2
      cd16726
      Location:728 → 764
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      cl17238
      Location:807 → 852
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    9. NM_001369167.1 → NP_001356096.1  E3 ubiquitin-protein ligase MIB2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627405
      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (5) summary
      PLN03192
      Location:428 → 492
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:461 → 712
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:465 → 495
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2

    10. NM_001369168.1 → NP_001356097.1  E3 ubiquitin-protein ligase MIB2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL627405
      Conserved Domains (5) summary
      PLN03192
      Location:392 → 456
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:425 → 676
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:429 → 459
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2

    11. NM_145124.3 → NP_660106.2  E3 ubiquitin-protein ligase MIB2 isoform 2

      See identical proteins and their annotated locations for NP_660106.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 2, 3, 5, and 6 all encode the same isoform (2).
      Source sequence(s)
      AI837194, AK147940, AK159611, CJ076202
      Consensus CDS
      CCDS19035.1
      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Related
      ENSMUSP00000099465.4, ENSMUST00000103176.10
      Conserved Domains (7) summary
      PLN03192
      Location:392 → 456
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:425 → 676
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:429 → 459
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      cd16726
      Location:797 → 833
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      cl17238
      Location:876 → 921
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155738925..155753711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253881.1 → XP_030109741.1  E3 ubiquitin-protein ligase MIB2 isoform X5

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      UniProtKB/TrEMBL
      B2RUG2
      Conserved Domains (8) summary
      PLN03192
      Location:417 → 481
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:450 → 701
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:454 → 484
      ANK; ANK repeat [structural motif]
      cd16726
      Location:822 → 858
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:292 → 356
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:901 → 946
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_030253880.1 → XP_030109740.1  E3 ubiquitin-protein ligase MIB2 isoform X2

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:449 → 513
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:482 → 733
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:486 → 516
      ANK; ANK repeat [structural motif]
      cd00162
      Location:934 → 966
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:854 → 890
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:324 → 388
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:933 → 978
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_006539247.2 → XP_006539310.1  E3 ubiquitin-protein ligase MIB2 isoform X1

      See identical proteins and their annotated locations for XP_006539310.1

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:453 → 517
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:486 → 737
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:490 → 520
      ANK; ANK repeat [structural motif]
      cd00162
      Location:938 → 970
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:858 → 894
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:937 → 982
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_030253883.1 → XP_030109743.1  E3 ubiquitin-protein ligase MIB2 isoform X9

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:291 → 355
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:324 → 575
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:328 → 358
      ANK; ANK repeat [structural motif]
      cl00295
      Location:1 → 32
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cd00162
      Location:776 → 808
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:696 → 732
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:59 → 123
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:191 → 255
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:775 → 820
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    5. XM_036164531.1 → XP_036020424.1  E3 ubiquitin-protein ligase MIB2 isoform X7

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:316 → 380
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:349 → 600
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:353 → 383
      ANK; ANK repeat [structural motif]
      cd00162
      Location:801 → 833
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:721 → 757
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:59 → 123
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:191 → 255
      SH3_15; Mind bomb SH3 repeat domain
      cl00295
      Location:1 → 32
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cl17238
      Location:800 → 845
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    6. XM_006539255.2 → XP_006539318.1  E3 ubiquitin-protein ligase MIB2 isoform X6

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:352 → 416
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:385 → 636
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:389 → 419
      ANK; ANK repeat [structural motif]
      cl00295
      Location:1 → 32
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cd00162
      Location:837 → 869
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:757 → 793
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:59 → 123
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:227 → 291
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:836 → 881
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    7. XM_030253882.1 → XP_030109742.1  E3 ubiquitin-protein ligase MIB2 isoform X5

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      UniProtKB/TrEMBL
      B2RUG2
      Conserved Domains (8) summary
      PLN03192
      Location:417 → 481
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:450 → 701
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:454 → 484
      ANK; ANK repeat [structural motif]
      cd16726
      Location:822 → 858
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:292 → 356
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:901 → 946
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    8. XM_036164530.1 → XP_036020423.1  E3 ubiquitin-protein ligase MIB2 isoform X4

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:424 → 488
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:457 → 708
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:461 → 491
      ANK; ANK repeat [structural motif]
      cd00162
      Location:909 → 941
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:829 → 865
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:324 → 388
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:908 → 953
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    9. XM_036164529.1 → XP_036020422.1  E3 ubiquitin-protein ligase MIB2 isoform X3

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:428 → 492
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:461 → 712
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:465 → 495
      ANK; ANK repeat [structural motif]
      cd00162
      Location:913 → 945
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:833 → 869
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:912 → 957
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    10. XM_030253879.1 → XP_030109739.1  E3 ubiquitin-protein ligase MIB2 isoform X1

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:453 → 517
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:486 → 737
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:490 → 520
      ANK; ANK repeat [structural motif]
      cd00162
      Location:938 → 970
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:858 → 894
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:937 → 982
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    11. XM_006539251.4 → XP_006539314.1  E3 ubiquitin-protein ligase MIB2 isoform X1

      See identical proteins and their annotated locations for XP_006539314.1

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:453 → 517
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:486 → 737
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:490 → 520
      ANK; ANK repeat [structural motif]
      cd00162
      Location:938 → 970
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:858 → 894
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:937 → 982
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    12. XM_006539254.3 → XP_006539317.1  E3 ubiquitin-protein ligase MIB2 isoform X1

      See identical proteins and their annotated locations for XP_006539317.1

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (9) summary
      PLN03192
      Location:453 → 517
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:486 → 737
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:490 → 520
      ANK; ANK repeat [structural motif]
      cd00162
      Location:938 → 970
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:858 → 894
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:937 → 982
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    13. XM_006539249.4 → XP_006539312.1  E3 ubiquitin-protein ligase MIB2 isoform X1

      See identical proteins and their annotated locations for XP_006539312.1

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Related
      ENSMUST00000151843.8
      Conserved Domains (9) summary
      PLN03192
      Location:453 → 517
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:486 → 737
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:490 → 520
      ANK; ANK repeat [structural motif]
      cd00162
      Location:938 → 970
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:858 → 894
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:937 → 982
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    14. XM_011250353.2 → XP_011248655.1  E3 ubiquitin-protein ligase MIB2 isoform X10

      Conserved Domains (7) summary
      PLN03192
      Location:161 → 225
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:194 → 445
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:198 → 228
      ANK; ANK repeat [structural motif]
      cd00162
      Location:646 → 678
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd16726
      Location:566 → 602
      RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
      pfam18346
      Location:36 → 100
      SH3_15; Mind bomb SH3 repeat domain
      cl17238
      Location:645 → 690
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    15. XM_017320437.1 → XP_017175926.1  E3 ubiquitin-protein ligase MIB2 isoform X8

      UniProtKB/Swiss-Prot
      A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
      Conserved Domains (6) summary
      PLN03192
      Location:453 → 517
      PLN03192; Voltage-dependent potassium channel; Provisional
      PHA03095
      Location:486 → 737
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:89 → 133
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:490 → 520
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:160 → 224
      MIB_HERC2; Mib_herc2
      pfam18346
      Location:328 → 392
      SH3_15; Mind bomb SH3 repeat domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001256110.1: Suppressed sequence

      Description
      NM_001256110.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R516.2 GenPept UniProtKB/Swiss-Prot:Q8R516

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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