Prmt6 protein arginine N-methyltransferase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prmt6provided by MGI
Official Full Name: protein arginine N-methyltransferase 6provided by MGI
Primary source: MGI:MGI:2139971
See related: Ensembl:ENSMUSG00000049300 AllianceGenome:MGI:2139971
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hrmt1l6
Summary: Enables chromatin binding activity and histone-arginine N-methyltransferase activity. Involved in peptidyl-arginine N-methylation. Acts upstream of or within several processes, including cellular senescence; histone H3-R2 methylation; and negative regulation of nitrogen compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Is expressed in central nervous system and sensory organ. Orthologous to human PRMT6 (protein arginine methyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 8.9), adrenal adult (RPKM 6.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F3; 3 48.52 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (110153420..110158315, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (110246104..110250999, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRMT6 deficiency or inhibition alleviates neuropathic pain by decreasing glycolysis and inflammation in microglia.
Title: PRMT6 deficiency or inhibition alleviates neuropathic pain by decreasing glycolysis and inflammation in microglia.
Arginine Methylation of Integrin Alpha-4 Prevents Fibrosis Development in Alcohol-Associated Liver Disease.
Title: Arginine Methylation of Integrin Alpha-4 Prevents Fibrosis Development in Alcohol-Associated Liver Disease.
The N(6)-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6.
Title: The N(6)-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6.
Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6.
Title: Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6.
The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling.
Title: The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling.
Loss of PPARalpha from the intestine promotes colon carcinogenesis by increasing DNMT1/PRMT6-mediated DNA methylation.
Title: Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
It was confirmed that PRMT6 was involved in the process of adipocyte differentiation. In addition, PRMT6 interacted with, but did not methylate, PPARgamma. PRMT6 bound to the PPARresponsive regulatory element of the adipocyte Protein 2 (aP2) promoter in conjunction with PPARgamma and generated the repressive epigenetic mark arginine 2 on histone H3 asymmetric dimethylation, which suppressed aP2 gene expression.
Title: Protein arginine methyltransferase 6 suppresses adipogenic differentiation by repressing peroxisome proliferator‑activated receptor γ activity.
Six crystal structures of PRMT6 from Mus musculus, solved and refined at 1.34 A for the highest resolution structure are described.
Title: Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.
Prmt6 is important for embryonic stem cell pluripotency and self-renewal.
Title: Protein arginine methyltransferase 6 regulates embryonic stem cell identity.
The findings define a new regulator of p53 transcriptional regulation and define a role for PRMT6 and arginine methylation in cellular senescence.
Title: Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234808

BB286044 (e-PCR)
- UniSTS:207554

Prmt6 (e-PCR), detects polymorphism
- UniSTS:479207

AW124876 (e-PCR)
- UniSTS:178919

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AR3 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3R2 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3R2 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4R3 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-arginine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine omega-N asymmetric methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine omega-N monomethyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-arginine methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein arginine N-methyltransferase 6

Names: HMT1 hnRNP methyltransferase-like 6; histone-arginine N-methyltransferase PRMT6

NP_849222.3

EC 2.1.1.319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178891.5 → NP_849222.3 protein arginine N-methyltransferase 6

See identical proteins and their annotated locations for NP_849222.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript, is intronless and encodes the functional protein.

Source sequence(s)

AC142115, AK034732, BG229470, BY033966

Consensus CDS

CCDS38605.1

UniProtKB/Swiss-Prot

Q3TA42, Q6NZB1, Q8BN52, Q8BSC2, Q8R5D7

Related

ENSMUSP00000102177.2, ENSMUST00000106567.2

Conserved Domains (1) summary

pfam12847
Location:85 → 188

Methyltransf_18; Methyltransferase domain

RNA

NR_024139.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) is spliced compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC142115, BB253593, BC066221, BY033966