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    Srsf11 serine and arginine-rich splicing factor 11 [ Mus musculus (house mouse) ]

    Gene ID: 69207, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Srsf11provided by MGI
    Official Full Name
    serine and arginine-rich splicing factor 11provided by MGI
    Primary source
    MGI:MGI:1916457
    See related
    Ensembl:ENSMUSG00000055436 AllianceGenome:MGI:1916457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sfrs11; 0610009J05Rik; 2610019N13Rik
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 60.3), CNS E14 (RPKM 43.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srsf11 in Genome Data Viewer
    Location:
    3 H4; 3 81.63 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157716552..157742304, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (158010915..158036667, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810013D15 gene Neighboring gene STARR-positive B cell enhancer ABC_E2102 Neighboring gene STARR-seq mESC enhancer starr_09387 Neighboring gene STARR-positive B cell enhancer ABC_E7952 Neighboring gene STARR-positive B cell enhancer ABC_E8807 Neighboring gene ankyrin repeat domain 13c Neighboring gene STARR-seq mESC enhancer starr_09389 Neighboring gene STARR-positive B cell enhancer ABC_E2684 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157723907-157724208 Neighboring gene STARR-positive B cell enhancer ABC_E11232 Neighboring gene STARR-positive B cell enhancer ABC_E7953 Neighboring gene leucine rich repeat containing 40 Neighboring gene leucine rich repeat containing 7 Neighboring gene STARR-seq mESC enhancer starr_09391 Neighboring gene STARR-seq mESC enhancer starr_09392

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE. Raihan O, et al. Cell Rep, 2019 Jul 2. PMID 31269452
    2. Splicing factor TRA2B is required for neural progenitor survival. Roberts JM, et al. J Comp Neurol, 2014 Feb 1. PMID 23818142, Free PMC Article
    3. A genetic analysis of neural progenitor differentiation. Geschwind DH, et al. Neuron, 2001 Feb. PMID 11239426
    4. USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation. Goldbraikh D, et al. EMBO Rep, 2020 Apr 3. PMID 32133736, Free PMC Article
    5. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Easterday MC, et al. Dev Biol, 2003 Dec 15. PMID 14651920

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
      Title: SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 11
    Names
    splicing factor, arginine/serine-rich 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001093752.5 → NP_001087221.2  serine/arginine-rich splicing factor 11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC145301
      Consensus CDS
      CCDS51103.1
      UniProtKB/TrEMBL
      Q3UIX4
      Related
      ENSMUSP00000113685.2, ENSMUST00000121326.8

    2. NM_001093753.3 → NP_001087222.1  serine/arginine-rich splicing factor 11 isoform 1

      See identical proteins and their annotated locations for NP_001087222.1

      Status: REVIEWED

      Source sequence(s)
      AC145301
      Consensus CDS
      CCDS51102.1
      UniProtKB/TrEMBL
      F6RDI8, Q3UIX4
      Related
      ENSMUSP00000072651.9, ENSMUST00000072875.15
      Conserved Domains (1) summary
      cd12518
      Location:27 → 106
      RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    3. NM_001379531.3 → NP_001366460.2  serine/arginine-rich splicing factor 11 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC145301
      Related
      ENSMUSP00000063916.9, ENSMUST00000069025.14

    4. NM_001379532.3 → NP_001366461.2  serine/arginine-rich splicing factor 11 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC145301

    5. NM_001379533.1 → NP_001366462.1  serine/arginine-rich splicing factor 11 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC145301
      UniProtKB/TrEMBL
      F6RDI8
      Conserved Domains (1) summary
      cd12518
      Location:27 → 106
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    6. NM_001426772.1 → NP_001413701.1  serine/arginine-rich splicing factor 11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC145301

    7. NM_001426773.1 → NP_001413702.1  serine/arginine-rich splicing factor 11 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC145301

    8. NM_001426774.1 → NP_001413703.1  serine/arginine-rich splicing factor 11 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC145301
      UniProtKB/TrEMBL
      Q3UIX4

    9. NM_001426775.1 → NP_001413704.1  serine/arginine-rich splicing factor 11 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC145301

    10. NM_001426776.1 → NP_001413705.1  serine/arginine-rich splicing factor 11 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC145301

    11. NM_001426777.1 → NP_001413706.1  serine/arginine-rich splicing factor 11 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC145301

    12. NM_001426778.1 → NP_001413707.1  serine/arginine-rich splicing factor 11 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC145301

    RNA

    1. NR_166757.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    2. NR_166758.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    3. NR_166759.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    4. NR_166760.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    5. NR_166761.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    6. NR_166762.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    7. NR_166763.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    8. NR_166764.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    9. NR_166765.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    10. NR_166766.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    11. NR_190054.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC145301

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      157716552..157742304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163271.1 → XP_036019164.1  serine/arginine-rich splicing factor 11 isoform X2

      UniProtKB/TrEMBL
      F6RDI8
      Conserved Domains (1) summary
      cd12518
      Location:27 → 106
      RRM_SRSF11; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

    2. XM_036163280.1 → XP_036019173.1  serine/arginine-rich splicing factor 11 isoform X8

    3. XM_036163275.1 → XP_036019168.1  serine/arginine-rich splicing factor 11 isoform X3

      UniProtKB/TrEMBL
      B7ZNC5

    4. XM_036163274.1 → XP_036019167.1  serine/arginine-rich splicing factor 11 isoform X3

      UniProtKB/TrEMBL
      B7ZNC5

    5. XM_036163273.1 → XP_036019166.1  serine/arginine-rich splicing factor 11 isoform X3

      UniProtKB/TrEMBL
      B7ZNC5

    6. XM_036163279.1 → XP_036019172.1  serine/arginine-rich splicing factor 11 isoform X7

    7. XM_006502022.3 → XP_006502085.1  serine/arginine-rich splicing factor 11 isoform X7

    8. XM_036163285.1 → XP_036019178.1  serine/arginine-rich splicing factor 11 isoform X9

    9. XM_036163278.1 → XP_036019171.1  serine/arginine-rich splicing factor 11 isoform X7

    10. XM_036163284.1 → XP_036019177.1  serine/arginine-rich splicing factor 11 isoform X9

    11. XM_030252790.2 → XP_030108650.1  serine/arginine-rich splicing factor 11 isoform X3

      UniProtKB/TrEMBL
      B7ZNC5

    12. XM_036163282.1 → XP_036019175.1  serine/arginine-rich splicing factor 11 isoform X8

    13. XM_036163277.1 → XP_036019170.1  serine/arginine-rich splicing factor 11 isoform X7

    14. XM_036163272.1 → XP_036019165.1  serine/arginine-rich splicing factor 11 isoform X3

      UniProtKB/TrEMBL
      B7ZNC5

    15. XM_036163283.1 → XP_036019176.1  serine/arginine-rich splicing factor 11 isoform X9

    16. XM_036163281.1 → XP_036019174.1  serine/arginine-rich splicing factor 11 isoform X8

    17. XM_036163276.1 → XP_036019169.1  serine/arginine-rich splicing factor 11 isoform X7

    18. XM_030252791.2 → XP_030108651.1  serine/arginine-rich splicing factor 11 isoform X5

      UniProtKB/TrEMBL
      B7ZNC5

    19. XM_030252793.2 → XP_030108653.1  serine/arginine-rich splicing factor 11 isoform X4

      UniProtKB/TrEMBL
      B7ZNC5, Q8BV04

    20. XM_030252792.2 → XP_030108652.1  serine/arginine-rich splicing factor 11 isoform X6

      UniProtKB/TrEMBL
      B7ZNC5

    RNA

    1. XR_001783740.2 RNA Sequence

    2. XR_375573.4 RNA Sequence

    3. XR_001783741.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001356997.1: Suppressed sequence

      Description
      NM_001356997.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

    2. NM_026989.3: Suppressed sequence

      Description
      NM_026989.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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