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    Lcn2 lipocalin 2 [ Mus musculus (house mouse) ]

    Gene ID: 16819, updated on 31-May-2021

    Summary

    Official Symbol
    Lcn2provided by MGI
    Official Full Name
    lipocalin 2provided by MGI
    Primary source
    MGI:MGI:96757
    See related
    Ensembl:ENSMUSG00000026822
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N; 24p; NRL; 24p3; Sip24; AW212229
    Expression
    Biased expression in genital fat pad adult (RPKM 1633.0), liver E18 (RPKM 272.6) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lcn2 in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32274649..32277751, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32384637..32387739, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (32240157..32243259, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene bublin coiled coil protein Neighboring gene prostaglandin E synthase 2 Neighboring gene predicted gene 13413

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enterobactin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small molecule binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of cell projection organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to herbicide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sequestering of iron ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in siderophore transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in siderophore transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neutrophil gelatinase-associated lipocalin
    Names
    SV-40-induced 24P3 protein
    neu-related lipocalin
    oncogene 24p3
    p25
    secreted inducible protein 24
    siderocalin LCN2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008491.1NP_032517.1  neutrophil gelatinase-associated lipocalin precursor

      See identical proteins and their annotated locations for NP_032517.1

      Status: PROVISIONAL

      Source sequence(s)
      X14607
      Consensus CDS
      CCDS15913.1
      UniProtKB/Swiss-Prot
      P11672
      Related
      ENSMUSP00000053962.9, ENSMUST00000050785.14
      Conserved Domains (1) summary
      pfam00061
      Location:49195
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32274649..32277751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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