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    Pcnp PEST proteolytic signal containing nuclear protein [ Mus musculus (house mouse) ]

    Gene ID: 76302, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pcnpprovided by MGI
    Official Full Name
    PEST proteolytic signal containing nuclear proteinprovided by MGI
    Primary source
    MGI:MGI:1923552
    See related
    Ensembl:ENSMUSG00000071533 AllianceGenome:MGI:1923552
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110018D06Rik
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in nuclear body. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human PCNP (PEST proteolytic signal containing nuclear protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 33.7), CNS E14 (RPKM 24.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 C1.1; 16 33.77 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (55835870..55851590, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (56015507..56029727, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2466 Neighboring gene STARR-positive B cell enhancer ABC_E4180 Neighboring gene zinc finger and BTB domain containing 11, opposite strand 1 Neighboring gene ribosomal protein L24 Neighboring gene STARR-seq mESC enhancer starr_41052 Neighboring gene zinc finger and BTB domain containing 11 Neighboring gene STARR-positive B cell enhancer ABC_E10912 Neighboring gene STARR-positive B cell enhancer ABC_E5549 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene predicted gene, 22422 Neighboring gene predicted gene, 57818 Neighboring gene SUMO1/sentrin specific peptidase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response. Hallé M, et al. Mol Cell Biol, 2007 Feb. PMID 17130234, Free PMC Article
    2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
    5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PEST proteolytic signal-containing nuclear protein
    Names
    PEST-containing nuclear protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024622.2 → NP_001019793.1  PEST proteolytic signal-containing nuclear protein isoform 4

      See identical proteins and their annotated locations for NP_001019793.1

      Status: VALIDATED

      Source sequence(s)
      BC061235, BC106192, BY287179
      Consensus CDS
      CCDS37357.1
      UniProtKB/Swiss-Prot
      Q6P8I4
      UniProtKB/TrEMBL
      Q3UCC5
      Related
      ENSMUSP00000110087.3, ENSMUST00000114444.9
      Conserved Domains (1) summary
      pfam15473
      Location:23 → 171
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    2. NM_001356448.1 → NP_001343377.1  PEST proteolytic signal-containing nuclear protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC171202
      Conserved Domains (1) summary
      pfam15473
      Location:20 → 151
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    3. NM_001356449.1 → NP_001343378.1  PEST proteolytic signal-containing nuclear protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC171202
      Consensus CDS
      CCDS88942.1
      UniProtKB/TrEMBL
      F8WI88
      Related
      ENSMUSP00000093720.4, ENSMUST00000096021.10
      Conserved Domains (1) summary
      pfam15473
      Location:34 → 182
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    4. NM_001356450.1 → NP_001343379.1  PEST proteolytic signal-containing nuclear protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC171202
      Related
      ENSMUSP00000112565.2, ENSMUST00000119981.8
      Conserved Domains (1) summary
      pfam15473
      Location:1 → 103
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      55835870..55851590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522697.5 → XP_006522760.1  PEST proteolytic signal-containing nuclear protein isoform X2

      See identical proteins and their annotated locations for XP_006522760.1

      Conserved Domains (1) summary
      pfam15473
      Location:23 → 170
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    2. XM_036160175.1 → XP_036016068.1  PEST proteolytic signal-containing nuclear protein isoform X1

      Conserved Domains (1) summary
      pfam15473
      Location:75 → 212
      PCNP; PEST, proteolytic signal-containing nuclear protein family

    3. XM_030249326.1 → XP_030105186.1  PEST proteolytic signal-containing nuclear protein isoform X3

      Conserved Domains (1) summary
      pfam15473
      Location:20 → 150
      PCNP; PEST, proteolytic signal-containing nuclear protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P8I4.1 GenPept UniProtKB/Swiss-Prot:Q6P8I4

    Gene LinkOut

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