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    Ttpal tocopherol (alpha) transfer protein-like [ Mus musculus (house mouse) ]

    Gene ID: 76080, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ttpalprovided by MGI
    Official Full Name
    tocopherol (alpha) transfer protein-likeprovided by MGI
    Primary source
    MGI:MGI:1923330
    See related
    Ensembl:ENSMUSG00000017679 AllianceGenome:MGI:1923330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110080A02Rik; 5830472M02Rik
    Summary
    Predicted to enable phosphatidylinositol bisphosphate binding activity. Orthologous to human TTPAL (alpha tocopherol transfer protein like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 8.0), spleen adult (RPKM 7.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H3; 2 84.37 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163444206..163460933)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163602285..163619013)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene hepatic nuclear factor 4 alpha, opposite strand Neighboring gene STARR-seq mESC enhancer starr_06311 Neighboring gene hepatic nuclear factor 4, alpha Neighboring gene predicted gene, 25881 Neighboring gene STARR-positive B cell enhancer ABC_E2652 Neighboring gene STARR-seq mESC enhancer starr_06312 Neighboring gene STARR-positive B cell enhancer ABC_E9538 Neighboring gene Crx opposite strand transcript 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2057 Neighboring gene serine incorporator 3 Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene STARR-positive B cell enhancer ABC_E10159 Neighboring gene STARR-positive B cell enhancer ABC_E9208 Neighboring gene STARR-positive B cell enhancer ABC_E819 Neighboring gene STARR-seq mESC enhancer starr_06314 Neighboring gene STARR-positive B cell enhancer ABC_E2058 Neighboring gene protein kinase inhibitor, gamma Neighboring gene predicted gene 16316

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidylinositol bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    alpha-tocopherol transfer protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305803.1 → NP_001292732.1  alpha-tocopherol transfer protein-like isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site at an internal exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK033600, BC052389, BC060726, CK640285
      UniProtKB/Swiss-Prot
      Q9D3D0
      Conserved Domains (2) summary
      smart01100
      Location:57 → 103
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:122 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    2. NM_029512.2 → NP_083788.2  alpha-tocopherol transfer protein-like isoform 1

      See identical proteins and their annotated locations for NP_083788.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK043791, BC052389, BC060726, CJ183358
      Consensus CDS
      CCDS38317.1
      UniProtKB/Swiss-Prot
      A6PW51, Q3U0R3, Q7TS94, Q9D3D0
      Related
      ENSMUSP00000128922.2, ENSMUST00000171696.8
      Conserved Domains (2) summary
      smart01100
      Location:57 → 103
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:122 → 278
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    3. NM_181734.3 → NP_859423.2  alpha-tocopherol transfer protein-like isoform 1

      See identical proteins and their annotated locations for NP_859423.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK039450, BC052389
      Consensus CDS
      CCDS38317.1
      UniProtKB/Swiss-Prot
      A6PW51, Q3U0R3, Q7TS94, Q9D3D0
      Related
      ENSMUSP00000105035.4, ENSMUST00000109408.10
      Conserved Domains (2) summary
      smart01100
      Location:57 → 103
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:122 → 278
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    RNA

    1. NR_131225.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate internal splice site and lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK039450, BC052389, BC060726, BY717985
      Related
      ENSMUST00000109405.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163444206..163460933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500362.3 → XP_006500425.1  alpha-tocopherol transfer protein-like isoform X1

      See identical proteins and their annotated locations for XP_006500425.1

      UniProtKB/Swiss-Prot
      A6PW51, Q3U0R3, Q7TS94, Q9D3D0
      Conserved Domains (2) summary
      smart01100
      Location:57 → 103
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:122 → 278
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    2. XM_006500361.3 → XP_006500424.1  alpha-tocopherol transfer protein-like isoform X1

      See identical proteins and their annotated locations for XP_006500424.1

      UniProtKB/Swiss-Prot
      A6PW51, Q3U0R3, Q7TS94, Q9D3D0
      Conserved Domains (2) summary
      smart01100
      Location:57 → 103
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:122 → 278
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    3. XM_036162662.1 → XP_036018555.1  alpha-tocopherol transfer protein-like isoform X2

      Conserved Domains (2) summary
      smart01100
      Location:57 → 103
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:122 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    4. XM_017319317.3 → XP_017174806.1  alpha-tocopherol transfer protein-like isoform X2

      Conserved Domains (2) summary
      smart01100
      Location:57 → 103
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00170
      Location:122 → 272
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

    RNA

    1. XR_003953734.2 RNA Sequence

    2. XR_003953735.2 RNA Sequence

    3. XR_374538.5 RNA Sequence

    4. XR_003953736.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3D0.3 GenPept UniProtKB/Swiss-Prot:Q9D3D0

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