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    Tns1 tensin 1 [ Mus musculus (house mouse) ]

    Gene ID: 21961, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tns1provided by MGI
    Official Full Name
    tensin 1provided by MGI
    Primary source
    MGI:MGI:104552
    See related
    Ensembl:ENSMUSG00000055322 AllianceGenome:MGI:104552
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tns; 1110018I21Rik; 1200014E20Rik; E030018G17Rik; E030037J05Rik
    Summary
    Predicted to enable actin binding activity. Acts upstream of or within cell-substrate junction assembly and fibroblast migration. Located in focal adhesion. Is expressed in several structures, including future midbrain; gut; metanephros; nasal process; and yolk sac. Orthologous to human TNS1 (tensin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 128.6), bladder adult (RPKM 85.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C3; 1 38.17 cM
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (73949391..74163707, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (73910232..74124548, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6030407O03 gene Neighboring gene predicted gene 29183 Neighboring gene STARR-seq mESC enhancer starr_01316 Neighboring gene STARR-seq mESC enhancer starr_01317 Neighboring gene STARR-seq mESC enhancer starr_01318 Neighboring gene microRNA 6351 Neighboring gene STARR-seq mESC enhancer starr_01319 Neighboring gene STARR-seq mESC enhancer starr_01321 Neighboring gene predicted gene, 39664 Neighboring gene STARR-positive B cell enhancer ABC_E11074 Neighboring gene VISTA enhancer mm1630 Neighboring gene predicted gene, 31637 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene C-X-C motif chemokine receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A role of tensin in skeletal-muscle regeneration. Ishii A, et al. Biochem J, 2001 Jun 15. PMID 11389681, Free PMC Article
    2. Tensin1 positively regulates RhoA activity through its interaction with DLC1. Shih YP, et al. Biochim Biophys Acta, 2015 Dec. PMID 26427649, Free PMC Article
    3. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. Chen H, et al. Proc Natl Acad Sci U S A, 2002 Jan 22. PMID 11792844, Free PMC Article
    4. Progressive kidney degeneration in mice lacking tensin. Lo SH, et al. J Cell Biol, 1997 Mar 24. PMID 9087448, Free PMC Article
    5. Molecular characterization of human tensin. Chen H, et al. Biochem J, 2000 Oct 15. PMID 11023826, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell-substrate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fibroblast migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-substrate junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tensin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289895.2 → NP_001276824.1  tensin-1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AC116419, AC117757
      Consensus CDS
      CCDS48288.2
      UniProtKB/TrEMBL
      A0A087WQS0, A0A1D5RM59
      Related
      ENSMUSP00000140317.2, ENSMUST00000191104.7
      Conserved Domains (5) summary
      cd09927
      Location:1591 → 1706
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:248 → 363
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:1728 → 1861
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:350 → 476
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl00040
      Location:75 → 108
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    2. NM_001413787.1 → NP_001400716.1  tensin-1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC116419, AC117757
      Related
      ENSMUSP00000140254.2, ENSMUST00000187584.7

    3. NM_001413788.1 → NP_001400717.1  tensin-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC116419

    4. NM_001413789.1 → NP_001400718.1  tensin-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC116419, AC117757

    5. NM_001413790.1 → NP_001400719.1  tensin-1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC116419, AC117757
      Related
      ENSMUSP00000140771.2, ENSMUST00000185331.7

    6. NM_001413791.1 → NP_001400720.1  tensin-1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC116419, AC117757

    7. NM_027884.4 → NP_082160.3  tensin-1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC116419, AC117757
      Consensus CDS
      CCDS78614.1
      UniProtKB/Swiss-Prot
      E9Q0S6
      UniProtKB/TrEMBL
      A0A1D5RM59
      Related
      ENSMUSP00000127715.2, ENSMUST00000169786.8
      Conserved Domains (5) summary
      cd09927
      Location:1612 → 1727
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00404
      Location:248 → 363
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      cd01213
      Location:1749 → 1882
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:350 → 476
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl00040
      Location:75 → 108
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      73949391..74163707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252982.1 → XP_030108842.1  tensin-1 isoform X8

      UniProtKB/TrEMBL
      A0A1D5RM59
      Conserved Domains (6) summary
      cd09927
      Location:1640 → 1755
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1067 → 1643
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1777 → 1910
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:350 → 476
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:75 → 108
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:185 → 343
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_006495871.4 → XP_006495934.1  tensin-1 isoform X7

      UniProtKB/TrEMBL
      A0A1D5RM59
      Conserved Domains (6) summary
      cd09927
      Location:1642 → 1757
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1069 → 1645
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1779 → 1912
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:350 → 476
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:75 → 108
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:185 → 343
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_017319864.1 → XP_017175353.1  tensin-1 isoform X15

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (7) summary
      cd09927
      Location:1595 → 1710
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:912 → 1598
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:689 → 1081
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1732 → 1865
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_017319860.1 → XP_017175349.1  tensin-1 isoform X12

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (7) summary
      cd09927
      Location:1603 → 1718
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:912 → 1606
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:689 → 1081
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1740 → 1873
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    5. XM_017319859.1 → XP_017175348.1  tensin-1 isoform X10

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1616 → 1731
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1043 → 1619
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1753 → 1886
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    6. XM_036163578.1 → XP_036019471.1  tensin-1 isoform X4

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1636 → 1751
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:964 → 1482
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1773 → 1906
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:61 → 116
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    7. XM_017319847.1 → XP_017175336.1  tensin-1 isoform X2

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1644 → 1759
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1071 → 1647
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1781 → 1914
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    8. XM_017319866.1 → XP_017175355.1  tensin-1 isoform X23

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (7) summary
      cd09927
      Location:1475 → 1590
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:907 → 1478
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1612 → 1745
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam03154
      Location:580 → 1028
      Atrophin-1; Atrophin-1 family
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    9. XM_030252984.1 → XP_030108844.1  tensin-1 isoform X22

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (7) summary
      cd09927
      Location:1506 → 1621
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:946 → 1509
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1643 → 1776
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam03154
      Location:580 → 1028
      Atrophin-1; Atrophin-1 family
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    10. XM_017319865.1 → XP_017175354.1  tensin-1 isoform X21

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1527 → 1642
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:976 → 1530
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1664 → 1797
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    11. XM_017319863.1 → XP_017175352.1  tensin-1 isoform X14

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (7) summary
      cd09927
      Location:1597 → 1712
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:914 → 1600
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:691 → 1083
      PHA03307; transcriptional regulator ICP4; Provisional
      cd01213
      Location:1734 → 1867
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    12. XM_036163588.1 → XP_036019481.1  tensin-1 isoform X11

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1610 → 1725
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1045 → 1613
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1747 → 1880
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:61 → 116
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    13. XM_017319858.1 → XP_017175347.1  tensin-1 isoform X9

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1618 → 1733
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1045 → 1621
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1755 → 1888
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    14. XM_017319856.1 → XP_017175345.1  tensin-1 isoform X6

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1625 → 1740
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:966 → 1471
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1762 → 1895
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    15. XM_017319848.1 → XP_017175337.1  tensin-1 isoform X3

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1638 → 1753
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:966 → 1484
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1775 → 1908
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    16. XM_017319853.1 → XP_017175342.1  tensin-1 isoform X5

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1633 → 1748
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:966 → 1479
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1770 → 1903
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    17. XM_006495867.2 → XP_006495930.2  tensin-1 isoform X1

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1646 → 1761
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1073 → 1649
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1783 → 1916
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:354 → 480
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:79 → 112
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:189 → 347
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    18. XM_006495878.4 → XP_006495941.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495941.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1492 → 1607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:919 → 1495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1629 → 1762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    19. XM_017319862.3 → XP_017175351.1  tensin-1 isoform X13

      UniProtKB/TrEMBL
      A0A6I8MWZ2
      Conserved Domains (6) summary
      cd09927
      Location:1622 → 1737
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1049 → 1625
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1759 → 1892
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:330 → 456
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:55 → 88
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:165 → 323
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    20. XM_030252983.1 → XP_030108843.1  tensin-1 isoform X17

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1599 → 1714
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1026 → 1602
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1736 → 1869
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:309 → 435
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:34 → 67
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:144 → 302
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    21. XM_006495872.1 → XP_006495935.1  tensin-1 isoform X16

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (6) summary
      cd09927
      Location:1601 → 1716
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:1028 → 1604
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1738 → 1871
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:309 → 435
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl00040
      Location:34 → 67
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl28904
      Location:144 → 302
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    22. XM_006495875.2 → XP_006495938.1  tensin-1 isoform X20

      UniProtKB/TrEMBL
      A0A087WQM0
      Conserved Domains (5) summary
      cd09927
      Location:1553 → 1668
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:980 → 1556
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1690 → 1823
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:261 → 387
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:96 → 254
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    23. XM_036163612.1 → XP_036019505.1  tensin-1 isoform X26

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1482 → 1597
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:810 → 1328
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1619 → 1752
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    24. XM_011238476.3 → XP_011236778.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_011236778.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1492 → 1607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:919 → 1495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1629 → 1762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    25. XM_006495874.4 → XP_006495937.1  tensin-1 isoform X19

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1568 → 1683
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:995 → 1571
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1705 → 1838
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:276 → 402
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:111 → 269
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    26. XM_030252985.2 → XP_030108845.1  tensin-1 isoform X25

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1490 → 1605
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:917 → 1493
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1627 → 1760
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    27. XM_006495877.4 → XP_006495940.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495940.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1492 → 1607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:919 → 1495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1629 → 1762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    28. XM_006495880.4 → XP_006495943.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495943.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1492 → 1607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:919 → 1495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1629 → 1762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    29. XM_006495873.2 → XP_006495936.2  tensin-1 isoform X18

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1552 → 1667
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:979 → 1555
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1689 → 1822
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:260 → 386
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:95 → 253
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    30. XM_011238477.2 → XP_011236779.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_011236779.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1492 → 1607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:919 → 1495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1629 → 1762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    31. XM_006495879.1 → XP_006495942.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495942.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1492 → 1607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:919 → 1495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1629 → 1762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    32. XM_036163609.1 → XP_036019502.1  tensin-1 isoform X24

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1492 → 1607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:919 → 1495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1629 → 1762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    33. XM_006495881.4 → XP_006495944.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495944.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Conserved Domains (5) summary
      cd09927
      Location:1492 → 1607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:919 → 1495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1629 → 1762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    34. XM_006495882.4 → XP_006495945.1  tensin-1 isoform X24

      See identical proteins and their annotated locations for XP_006495945.1

      UniProtKB/TrEMBL
      A0A087WQ94
      Related
      ENSMUSP00000140094.2, ENSMUST00000185702.7
      Conserved Domains (5) summary
      cd09927
      Location:1492 → 1607
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:919 → 1495
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1629 → 1762
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:200 → 326
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein
      cl28904
      Location:35 → 193
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    35. XM_030252988.1 → XP_030108848.1  tensin-1 isoform X33

      Conserved Domains (3) summary
      cd09927
      Location:842 → 957
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:274 → 845
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:979 → 1112
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    36. XM_036163624.1 → XP_036019517.1  tensin-1 isoform X32

      Conserved Domains (3) summary
      cd09927
      Location:886 → 1001
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:343 → 889
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1023 → 1156
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    37. XM_030252987.1 → XP_030108847.1  tensin-1 isoform X31

      Conserved Domains (3) summary
      cd09927
      Location:964 → 1079
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:282 → 931
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1101 → 1234
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    38. XM_036163621.1 → XP_036019514.1  tensin-1 isoform X30

      Conserved Domains (3) summary
      cd09927
      Location:977 → 1092
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:412 → 944
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1114 → 1247
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    39. XM_030252986.1 → XP_030108846.1  tensin-1 isoform X29

      Conserved Domains (3) summary
      cd09927
      Location:985 → 1100
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:412 → 952
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1122 → 1255
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    40. XM_036163620.1 → XP_036019513.1  tensin-1 isoform X28

      Conserved Domains (3) summary
      cd09927
      Location:1005 → 1120
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:333 → 851
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1142 → 1275
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    41. XM_006495883.2 → XP_006495946.1  tensin-1 isoform X27

      Conserved Domains (3) summary
      cd09927
      Location:1013 → 1128
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      PHA03247
      Location:440 → 980
      PHA03247; large tegument protein UL36; Provisional
      cd01213
      Location:1150 → 1283
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177169.2: Suppressed sequence

      Description
      NM_177169.2: This RefSeq was permanently suppressed because it contains the wrong CDS.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q0S6.1 GenPept UniProtKB/Swiss-Prot:E9Q0S6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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