Caly calcyon neuron-specific vesicular protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Calyprovided by MGI
Official Full Name: calcyon neuron-specific vesicular proteinprovided by MGI
Primary source: MGI:MGI:1915816
See related: Ensembl:ENSMUSG00000025468 AllianceGenome:MGI:1915816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Drd1ip; Calcyon; 0710001P07Rik; 1110004A22Rik
Summary: Predicted to enable clathrin light chain binding activity. Involved in postsynaptic neurotransmitter receptor internalization. Located in glutamatergic synapse. Is expressed in central nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human CALY (calcyon neuron specific vesicular protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 66.1), CNS E18 (RPKM 58.8) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F4; 7 85.07 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (139649793..139662485, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (140069880..140082571, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data suggest that upregulation of calcyon in forebrain could increase BP via alterations in noradrenergic transmission and increased oxidative stress during high salt challenge.
Title: Increased arterial pressure in mice with overexpression of the ADHD candidate gene calcyon in forebrain.
endocytic and cargo sorting functions of Caly in neurons
Title: Dynein binds and stimulates axonal motility of the endosome adaptor and NEEP21 family member, calcyon.
The data of this study suggested that calcyon directly interacts with mu3A and mu3B, and regulates the subcellular distribution of AP-3 and the targeting of AP-3 cargoes.
Title: Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.
The resultd of this study showed that with calcyon-overexpressing Cal(OE) transgenic mice that lifelong calcyon upregulation impairs executive functions including response inhibition and working memory.
Title: Calcyon upregulation in adolescence impairs response inhibition and working memory in adulthood.
Taken together, the present studies involving biochemical, immunological and electrophysiological analyses raise the possibility that calcyon plays a specialized role in regulating activity-dependent removal of synaptic AMPARs.
Title: Calcyon is necessary for activity-dependent AMPA receptor internalization and LTD in CA1 neurons of hippocampus.
Transgenic mice display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety, and/or impaired restraint (harm avoidance) that would indicate that calcyon up-regulation leads to deficits in control over behavioral output.
Title: Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables clathrin light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin light chain binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	ISO Inferred from Sequence Orthology more info
involved_in clathrin coat assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat assembly	ISO Inferred from Sequence Orthology more info
involved_in dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of clathrin coat assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of retrograde axon cargo transport	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	IEP Inferred from Expression Pattern more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic endocytic zone	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuron-specific vesicular protein calcyon

Names: calcyon; D1 dopamine receptor-interacting protein; dopamine receptor D1 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190385.1 → NP_001177314.1 neuron-specific vesicular protein calcyon

See identical proteins and their annotated locations for NP_001177314.1

Status: VALIDATED

Description

Transcript Variant: This variant (B) differs in the 3' UTR compared to variant A, and is also known as mcal-B. Variants A, B and C encode the same protein.

Source sequence(s)

AK002979, AK003400

Consensus CDS

CCDS21962.1

UniProtKB/Swiss-Prot

Q9D1K9, Q9DCA7

Related

ENSMUSP00000026541.8, ENSMUST00000026541.15

Conserved Domains (1) summary

pfam06387
Location:1 → 182

Calcyon; D1 dopamine receptor-interacting protein (calcyon)
NM_001190386.1 → NP_001177315.1 neuron-specific vesicular protein calcyon

See identical proteins and their annotated locations for NP_001177315.1

Status: VALIDATED

Description

Transcript Variant: This variant (C) differs in the 5' UTR compared to variant A. Variants A, B and C encode the same protein.

Source sequence(s)

AC109205

Consensus CDS

CCDS21962.1

UniProtKB/Swiss-Prot

Q9D1K9, Q9DCA7

Related

ENSMUSP00000130779.3, ENSMUST00000166758.4

Conserved Domains (1) summary

pfam06387
Location:1 → 182

Calcyon; D1 dopamine receptor-interacting protein (calcyon)
NM_026769.5 → NP_081045.2 neuron-specific vesicular protein calcyon

See identical proteins and their annotated locations for NP_081045.2

Status: VALIDATED

Description

Transcript Variant: This variant (A) represents the shortest transcript, and is also known as mcal-A. Variants A, B and C encode the same protein.

Source sequence(s)

AC109205, AK002979, AK003400

Consensus CDS

CCDS21962.1

UniProtKB/Swiss-Prot

Q9D1K9, Q9DCA7

Related

ENSMUSP00000148173.2, ENSMUST00000211283.2

Conserved Domains (1) summary

pfam06387
Location:1 → 182

Calcyon; D1 dopamine receptor-interacting protein (calcyon)