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    Ddi2 DNA-damage inducible protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 68817, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ddi2provided by MGI
    Official Full Name
    DNA-damage inducible protein 2provided by MGI
    Primary source
    MGI:MGI:1917244
    See related
    Ensembl:ENSMUSG00000078515 AllianceGenome:MGI:1917244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110056G13Rik; 1700027M01Rik; 9130022E05Rik
    Summary
    Predicted to enable aspartic-type endopeptidase activity; identical protein binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including cellular response to hydroxyurea; proteolysis; and regulation of DNA stability. Predicted to be located in cytosol and nucleoplasm. Is expressed in brain. Orthologous to human DDI2 (DNA damage inducible 1 homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 38.6), bladder adult (RPKM 18.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ddi2 in Genome Data Viewer
    Location:
    4 D3; 4 74.69 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141410874..141450730, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141683563..141723419, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:141180986-141181286 Neighboring gene solute carrier family 25, member 34 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 2 Neighboring gene predicted gene, 54266 Neighboring gene STARR-seq mESC enhancer starr_11927 Neighboring gene regulatory solute carrier protein, family 1, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E11263 Neighboring gene predicted gene, 34863 Neighboring gene STARR-seq mESC enhancer starr_11931 Neighboring gene agmatinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-133 mediates cardiac diseases: Mechanisms and clinical implications. Liu Y, et al. Exp Cell Res, 2017 May 15. PMID 28322824
    2. The protease DDI2 regulates NRF1 activation in response to cadmium toxicity. Ribeiro ST, et al. iScience, 2022 Oct 21. PMID 36248746, Free PMC Article
    3. Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome. Ramirez J, et al. Hum Mol Genet, 2018 Jun 1. PMID 29788202
    4. Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation. Sha Z, et al. Curr Biol, 2016 Sep 26. PMID 27676298, Free PMC Article
    5. The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. Koizumi S, et al. Elife, 2016 Aug 16. PMID 27528193, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aspartic-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hydroxyurea ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein DDI1 homolog 2
    NP_001017966.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017966.2 → NP_001017966.1  protein DDI1 homolog 2

      See identical proteins and their annotated locations for NP_001017966.1

      Status: VALIDATED

      Source sequence(s)
      AL671733, BF468816, BY731719, CD550969
      Consensus CDS
      CCDS18880.1
      UniProtKB/Swiss-Prot
      A2ADY9
      Related
      ENSMUSP00000099542.5, ENSMUST00000102484.5
      Conserved Domains (2) summary
      cd05479
      Location:221 → 343
      RP_DDI; RP_DDI; retropepsin-like domain of DNA damage inducible protein
      cd01796
      Location:3 → 76
      DDI1_N; DNA damage inducible protein 1 ubiquitin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      141410874..141450730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2ADY9.1 GenPept UniProtKB/Swiss-Prot:A2ADY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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