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    Lrrcc1 leucine rich repeat and coiled-coil domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 71710, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Lrrcc1provided by MGI
    Official Full Name
    leucine rich repeat and coiled-coil domain containing 1provided by MGI
    Primary source
    MGI:MGI:1918960
    See related
    Ensembl:ENSMUSG00000027550 AllianceGenome:MGI:1918960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200008A14Rik; 4932441F23Rik
    Summary
    Predicted to act upstream of or within cell division. Predicted to be located in cytoskeleton. Predicted to be active in centrosome and cytoplasm. Is expressed in several structures, including alimentary system; cranium; genitourinary system; heart valve; and nervous system. Orthologous to human LRRCC1 (leucine rich repeat and coiled-coil centrosomal protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 4.8), CNS E11.5 (RPKM 3.7) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 A1; 3 3.08 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (14595512..14637718)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (14533762..14572658)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene E2F transcription factor 5 Neighboring gene STARR-positive B cell enhancer ABC_E2065 Neighboring gene STARR-seq mESC enhancer starr_07000 Neighboring gene ribosomal biogenesis factor Neighboring gene STARR-seq mESC enhancer starr_07001 Neighboring gene predicted gene, 54191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In vitro selection of Jun-associated proteins using mRNA display. Horisawa K, et al. Nucleic Acids Res, 2004 Dec 2. PMID 15576676, Free PMC Article
    2. The transcription factor GATA-6 regulates pathological cardiac hypertrophy. van Berlo JH, et al. Circ Res, 2010 Oct 15. PMID 20705924, Free PMC Article
    3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106275

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and coiled-coil domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163579.1 → NP_001157051.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001157051.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC140350, BC138734
      Consensus CDS
      CCDS50866.1
      UniProtKB/Swiss-Prot
      B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
      UniProtKB/TrEMBL
      G5E8Y2
      Related
      ENSMUSP00000126560.2, ENSMUST00000169079.8
      Conserved Domains (9) summary
      COG0419
      Location:421 → 952
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG4886
      Location:30 → 115
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:43 → 61
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:158 → 188
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:61 → 101
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:82 → 142
      LRR_8; Leucine rich repeat
      pfam15665
      Location:793 → 1026
      FAM184; Family with sequence similarity 184, A and B
      cl00240
      Location:915 → 969
      RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
      cl19219
      Location:817 → 894
      DUF342; Protein of unknown function (DUF342)

    2. NM_001163580.1 → NP_001157052.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC140350, BC138734
      Consensus CDS
      CCDS50865.1
      UniProtKB/Swiss-Prot
      B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
      UniProtKB/TrEMBL
      E9QNC6
      Related
      ENSMUSP00000088875.4, ENSMUST00000091325.10
      Conserved Domains (9) summary
      COG0419
      Location:405 → 936
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG4886
      Location:30 → 115
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:43 → 61
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:158 → 188
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:61 → 101
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:82 → 142
      LRR_8; Leucine rich repeat
      pfam15665
      Location:777 → 1010
      FAM184; Family with sequence similarity 184, A and B
      cl00240
      Location:899 → 953
      RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
      cl19219
      Location:801 → 878
      DUF342; Protein of unknown function (DUF342)

    3. NM_028915.3 → NP_083191.2  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_083191.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC140350, AI646154, BC138734
      Consensus CDS
      CCDS38390.1
      UniProtKB/Swiss-Prot
      B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
      UniProtKB/TrEMBL
      A0A9L6HJP5
      Related
      ENSMUSP00000104007.3, ENSMUST00000108370.9
      Conserved Domains (8) summary
      COG4886
      Location:30 → 115
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:43 → 61
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:158 → 188
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:61 → 101
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:82 → 142
      LRR_8; Leucine rich repeat
      pfam15665
      Location:793 → 981
      FAM184; Family with sequence similarity 184, A and B
      cl00240
      Location:915 → 969
      RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
      cl19219
      Location:817 → 894
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      14595512..14637718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163334.1 → XP_036019227.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X4

      UniProtKB/Swiss-Prot
      B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
      Conserved Domains (2) summary
      COG0419
      Location:299 → 830
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd21340
      Location:2 → 75
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_030252826.1 → XP_030108686.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
      Conserved Domains (3) summary
      COG0419
      Location:340 → 871
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      sd00031
      Location:25 → 50
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:24 → 91
      LRR_8; Leucine rich repeat

    3. XM_006530089.3 → XP_006530152.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
      Conserved Domains (3) summary
      COG0419
      Location:340 → 871
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      sd00031
      Location:25 → 50
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:24 → 91
      LRR_8; Leucine rich repeat

    4. XM_036163333.1 → XP_036019226.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B2RS58, Q4FZD6, Q69ZB0, Q6P8L1, Q9CUE1, Q9DC06
      Conserved Domains (3) summary
      COG0419
      Location:324 → 855
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      sd00031
      Location:25 → 50
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:25 → 116
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    5. XM_006530090.4 → XP_006530153.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      F7ANC5
      Related
      ENSMUSP00000129368.2, ENSMUST00000167858.8
      Conserved Domains (2) summary
      COG1196
      Location:400 → 653
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:65 → 637
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_003954391.2 RNA Sequence

    2. XR_004941396.1 RNA Sequence

    3. XR_387522.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZB0.2 GenPept UniProtKB/Swiss-Prot:Q69ZB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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