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    Dnase1l1 deoxyribonuclease 1-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 69537, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dnase1l1provided by MGI
    Official Full Name
    deoxyribonuclease 1-like 1provided by MGI
    Primary source
    MGI:MGI:109628
    See related
    Ensembl:ENSMUSG00000019088 AllianceGenome:MGI:109628
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G4.8; Dnasex; Dnl1ll; Dnase1ll; 2310005K03Rik
    Summary
    Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process, endonucleolytic. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human DNASE1L1 (deoxyribonuclease 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 15.2), bladder adult (RPKM 10.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnase1l1 in Genome Data Viewer
    Location:
    X A7.3; X 37.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73316823..73325939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74273217..74282333, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene emerin Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47366 Neighboring gene ribosomal protein L10 Neighboring gene small nucleolar RNA, H/ACA box 70 Neighboring gene microRNA 7091 Neighboring gene predicted gene 14846 Neighboring gene tafazzin, phospholipid-lysophospholipid transacylase Neighboring gene STARR-positive B cell enhancer ABC_E7694 Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 1 Neighboring gene GDP dissociation inhibitor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells. Mohan Kumar D, et al. PLoS Pathog, 2013. PMID 24098122, Free PMC Article
    2. Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region. Pergolizzi R, et al. Gene, 1996 Feb 12. PMID 8654957
    3. Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X. Shiokawa D, et al. Biochem J, 2005 Dec 15. PMID 16107205, Free PMC Article
    4. A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Rivella S, et al. Genomics, 1995 Aug 10. PMID 7490070
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast two-hybrid screening revealed that DNase X, a glycosylphosphatidyl inositol-anchored mammalian cell-surface protein binds EtpE-C.
      Title: Ehrlichia chaffeensis uses its surface protein EtpE to bind GPI-anchored protein DNase X and trigger entry into mammalian cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyribonuclease I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    deoxyribonuclease-1-like 1
    Names
    DNase I-like 1
    DNase X
    deoxyribonuclease I-like 1
    NP_001165625.2
    NP_001357716.1
    NP_081385.2
    XP_006528335.1
    XP_006528336.1
    XP_017174102.1
    XP_017174103.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172154.2 → NP_001165625.2  deoxyribonuclease-1-like 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL807376
      Consensus CDS
      CCDS30223.1
      UniProtKB/Swiss-Prot
      Q3UD56, Q9D7J6
      UniProtKB/TrEMBL
      A0A158SIT2, A0A6I8MWW4
      Related
      ENSMUSP00000075218.4, ENSMUST00000075821.10
      Conserved Domains (1) summary
      cl00490
      Location:9 → 271
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. NM_001370787.1 → NP_001357716.1  deoxyribonuclease-1-like 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL807376
      UniProtKB/Swiss-Prot
      Q3UD56, Q9D7J6
      UniProtKB/TrEMBL
      A0A158SIT2
      Conserved Domains (1) summary
      cl00490
      Location:9 → 245
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    3. NM_027109.3 → NP_081385.2  deoxyribonuclease-1-like 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL807376
      Consensus CDS
      CCDS30223.1
      UniProtKB/Swiss-Prot
      Q3UD56, Q9D7J6
      UniProtKB/TrEMBL
      A0A158SIT2, A0A6I8MWW4
      Related
      ENSMUSP00000159292.2, ENSMUST00000239458.2
      Conserved Domains (1) summary
      cl00490
      Location:9 → 271
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      73316823..73325939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528273.5 → XP_006528336.1  deoxyribonuclease-1-like 1 isoform X2

      Conserved Domains (1) summary
      cl00490
      Location:27 → 191
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. XM_006528272.5 → XP_006528335.1  deoxyribonuclease-1-like 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UD56, Q9D7J6
      UniProtKB/TrEMBL
      A0A158SIT2
      Conserved Domains (1) summary
      cl00490
      Location:27 → 234
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    3. XM_017318613.3 → XP_017174102.1  deoxyribonuclease-1-like 1 isoform X3

      Conserved Domains (1) summary
      cl00490
      Location:63 → 161
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    4. XM_017318614.3 → XP_017174103.1  deoxyribonuclease-1-like 1 isoform X4

      Conserved Domains (1) summary
      cl00490
      Location:27 → 152
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7J6.3 GenPept UniProtKB/Swiss-Prot:Q9D7J6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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