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    Smc2 structural maintenance of chromosomes 2 [ Mus musculus (house mouse) ]

    Gene ID: 14211, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Smc2provided by MGI
    Official Full Name
    structural maintenance of chromosomes 2provided by MGI
    Primary source
    MGI:MGI:106067
    See related
    Ensembl:ENSMUSG00000028312 AllianceGenome:MGI:106067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAPE; CAP-E; Fin16; SMC-2; Smc2l1; 5730502P04Rik
    Summary
    The protein encoded by this gene is a component of both condensin I and condensin II complexes, and forms a heterodimer with structural maintenance of chromosome 4 (Smc4). This heterodimer is the catalytic subunit for both condensin complexes, and is involved in several processes, including chromosome condensation during mitosis and meiosis, cohesin removal during mitosis and meiosis, and single-strand break (SSB) repair. Reduced expression of this gene results in chromosome segregation defects during mitosis and meiosis, with a more severe defect observed in embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Biased expression in liver E14 (RPKM 13.6), CNS E11.5 (RPKM 12.6) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Smc2 in Genome Data Viewer
    Location:
    4 B2; 4 28.31 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (52438966..52488365)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (52439221..52488365)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA-directed), delta 3, accessory subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_10208 Neighboring gene STARR-seq mESC enhancer starr_10209 Neighboring gene STARR-positive B cell enhancer ABC_E3492 Neighboring gene structural maintenance of chromosomes 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_10210 Neighboring gene Tmc4 retrotransposed pseudogene Neighboring gene VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene Neighboring gene STARR-seq mESC enhancer starr_10212 Neighboring gene topoisomerase I binding, arginine/serine-rich like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells. Fazzio TG, et al. J Cell Biol, 2010 Feb 22. PMID 20176923, Free PMC Article
    2. Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins. Griese JJ, et al. Nucleic Acids Res, 2010 Jun. PMID 20139420, Free PMC Article
    3. Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions. Nishide K, et al. PLoS Genet, 2014 Dec. PMID 25474630, Free PMC Article
    4. YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus. Pan X, et al. EMBO J, 2013 Apr 17. PMID 23531880, Free PMC Article
    5. Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model. Kawakami Y, et al. Neurosci Res, 2009 Mar. PMID 19114063

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maternal SMC2 is essential for embryonic development via participating chromosome condensation in mice.
      Title: Maternal SMC2 is essential for embryonic development via participating chromosome condensation in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within kinetochore organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in single strand break repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in condensed chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of condensin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of condensin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of condensin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of condensin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    structural maintenance of chromosomes protein 2
    Names
    FGF-inducible protein 16
    SMC protein 2
    SMC2 structural maintenance of chromosomes 2-like 1
    XCAP-E homolog
    chromosome-associated protein E
    fibroblast growth factor inducible 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301412.1 → NP_001288341.1  structural maintenance of chromosomes protein 2

      See identical proteins and their annotated locations for NP_001288341.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK145341, BC094380, CJ049961
      Consensus CDS
      CCDS18180.1
      UniProtKB/Swiss-Prot
      Q52KE9, Q61076, Q8CG48, Q9CS17, Q9CSD8
      UniProtKB/TrEMBL
      Q3ULS2
      Related
      ENSMUSP00000099979.4, ENSMUST00000102915.10
      Conserved Domains (1) summary
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_008017.4 → NP_032043.3  structural maintenance of chromosomes protein 2

      See identical proteins and their annotated locations for NP_032043.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK145341, BC094380, CJ049961
      Consensus CDS
      CCDS18180.1
      UniProtKB/Swiss-Prot
      Q52KE9, Q61076, Q8CG48, Q9CS17, Q9CSD8
      UniProtKB/TrEMBL
      Q3ULS2
      Related
      ENSMUSP00000113940.2, ENSMUST00000117280.8
      Conserved Domains (1) summary
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      52438966..52488365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163679.1 → XP_036019572.1  structural maintenance of chromosomes protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q52KE9, Q61076, Q8CG48, Q9CS17, Q9CSD8
      UniProtKB/TrEMBL
      Q3ULS2
      Conserved Domains (1) summary
      COG1196
      Location:1 → 1168
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CG48.2 GenPept UniProtKB/Swiss-Prot:Q8CG48

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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