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    Hhipl1 hedgehog interacting protein-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 214305, updated on 12-May-2024

    Summary

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    Official Symbol
    Hhipl1provided by MGI
    Official Full Name
    hedgehog interacting protein-like 1provided by MGI
    Primary source
    MGI:MGI:1919265
    See related
    Ensembl:ENSMUSG00000021260 AllianceGenome:MGI:1919265
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1822; 1600002O04Rik
    Summary
    Predicted to enable catalytic activity and scavenger receptor activity. Predicted to be located in extracellular region and membrane. Is expressed in adrenal gland; cartilage; nervous system; stomach; and testis. Orthologous to human HHIPL1 (HHIP like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 2.7), ovary adult (RPKM 2.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hhipl1 in Genome Data Viewer
    Location:
    12 F1; 12 59.37 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (108272100..108294559)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (108305968..108328300)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene SET domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E743 Neighboring gene cyclin K Neighboring gene coiled-coil domain containing 85C Neighboring gene STARR-positive B cell enhancer mm9_chr12:109513689-109513989 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:109514813-109514922 Neighboring gene STARR-positive B cell enhancer mm9_chr12:109572195-109572495 Neighboring gene cytochrome P450, family 46, subfamily a, polypeptide 1 Neighboring gene echinoderm microtubule associated protein like 1 Neighboring gene bridging integrator 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus, Positively Regulates Hedgehog Signaling and Promotes Atherosclerosis. Aravani D, et al. Circulation, 2019 Aug 6. PMID 31163988, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • KIAA1822

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    HHIP-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044380.1 → NP_001037845.1  HHIP-like protein 1 precursor

      See identical proteins and their annotated locations for NP_001037845.1

      Status: PROVISIONAL

      Source sequence(s)
      BC113163
      Consensus CDS
      CCDS36554.1
      UniProtKB/Swiss-Prot
      Q14CI0, Q14DK5, Q3UGD3, Q3UU97, Q6ZPH6
      Related
      ENSMUSP00000021685.7, ENSMUST00000021685.8
      Conserved Domains (4) summary
      smart00202
      Location:682 → 785
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:689 → 785
      SRCR; Scavenger receptor cysteine-rich domain
      pfam03024
      Location:42 → 189
      Folate_rec; Folate receptor family
      pfam07995
      Location:199 → 445
      GSDH; Glucose / Sorbosone dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      108272100..108294559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515665.5 → XP_006515728.1  HHIP-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q14DK5
      Conserved Domains (2) summary
      pfam03024
      Location:42 → 189
      Folate_rec; Folate receptor family
      cl26817
      Location:199 → 445
      GSDH; Glucose / Sorbosone dehydrogenase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14DK5.1 GenPept UniProtKB/Swiss-Prot:Q14DK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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