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    Smim8 small integral membrane protein 8 [ Mus musculus (house mouse) ]

    Gene ID: 66291, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Smim8provided by MGI
    Official Full Name
    small integral membrane protein 8provided by MGI
    Primary source
    MGI:MGI:1913541
    See related
    Ensembl:ENSMUSG00000028295 AllianceGenome:MGI:1913541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810030N24Rik; 2810406B13Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human SMIM8 (small integral membrane protein 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 15.8), bladder adult (RPKM 7.4) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 A5; 4 16.86 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34768664..34778398, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34768664..34778396, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 206 Neighboring gene STARR-seq mESC enhancer starr_09914 Neighboring gene STARR-seq mESC enhancer starr_09915 Neighboring gene predicted gene 136 Neighboring gene STARR-seq mESC enhancer starr_09916 Neighboring gene STARR-seq mESC enhancer starr_09917 Neighboring gene predicted gene, 57497 Neighboring gene zinc finger protein 292 Neighboring gene STARR-positive B cell enhancer mm9_chr4:34767165-34767465 Neighboring gene tubulin, beta 6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Oyama Y, et al. Asian J Androl, 2022 May-Jun. PMID 34290169, Free PMC Article
    2. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small integral membrane protein 8
    Names
    UPF0708 protein C6orf162 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330755.1 → NP_001317684.1  small integral membrane protein 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK005941, AK021236, BU946215, CO040081
      Consensus CDS
      CCDS38706.1
      UniProtKB/Swiss-Prot
      Q9CQQ0, Q9CY70
      Related
      ENSMUSP00000103766.2, ENSMUST00000108131.8
      Conserved Domains (1) summary
      pfam14937
      Location:16 → 96
      DUF4500; Domain of unknown function (DUF4500)

    2. NM_001330756.1 → NP_001317685.1  small integral membrane protein 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK005941, AK007660, AK021236, CO040081
      Consensus CDS
      CCDS38706.1
      UniProtKB/Swiss-Prot
      Q9CQQ0, Q9CY70
      Related
      ENSMUSP00000103769.2, ENSMUST00000108134.8
      Conserved Domains (1) summary
      pfam14937
      Location:16 → 96
      DUF4500; Domain of unknown function (DUF4500)

    3. NM_001330757.1 → NP_001317686.1  small integral membrane protein 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK007660, AK021236, CO040081
      Consensus CDS
      CCDS38706.1
      UniProtKB/Swiss-Prot
      Q9CQQ0, Q9CY70
      Related
      ENSMUSP00000029972.4, ENSMUST00000029972.4
      Conserved Domains (1) summary
      pfam14937
      Location:16 → 96
      DUF4500; Domain of unknown function (DUF4500)

    4. NM_025471.3 → NP_079747.1  small integral membrane protein 8

      See identical proteins and their annotated locations for NP_079747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK005941, AK021236, CO040081
      Consensus CDS
      CCDS38706.1
      UniProtKB/Swiss-Prot
      Q9CQQ0, Q9CY70
      Related
      ENSMUSP00000103768.4, ENSMUST00000108133.10
      Conserved Domains (1) summary
      pfam14937
      Location:16 → 96
      DUF4500; Domain of unknown function (DUF4500)

    RNA

    1. NR_138487.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL928738, CO040081
      Related
      ENSMUST00000139922.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      34768664..34778398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538163.3 → XP_006538226.1  small integral membrane protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006538226.1

      UniProtKB/Swiss-Prot
      Q9CQQ0, Q9CY70
      Related
      ENSMUSP00000103767.2, ENSMUST00000108132.8
      Conserved Domains (1) summary
      pfam14937
      Location:16 → 96
      DUF4500; Domain of unknown function (DUF4500)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQQ0.1 GenPept UniProtKB/Swiss-Prot:Q9CQQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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