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    Kynu kynureninase [ Mus musculus (house mouse) ]

    Gene ID: 70789, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kynuprovided by MGI
    Official Full Name
    kynureninaseprovided by MGI
    Primary source
    MGI:MGI:1918039
    See related
    Ensembl:ENSMUSG00000026866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4432411A05Rik
    Expression
    Biased expression in liver adult (RPKM 9.9), liver E18 (RPKM 4.5) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kynu in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (43445270..43573060)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (43555258..43683048)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (43410849..43538235)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54112 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 30374 Neighboring gene Rho GTPase activating protein 15 Neighboring gene predicted gene, 39804

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxykynureninase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kynureninase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables kynureninase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anthranilate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in anthranilate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in quinolinate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to vitamin B6 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tryptophan catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tryptophan catabolic process to acetyl-CoA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tryptophan catabolic process to kynurenine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kynureninase
    Names
    L-kynurenine hydrolase
    NP_001276522.1
    NP_001276523.1
    NP_081828.1
    XP_006498388.1
    XP_011237480.1
    XP_011237481.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289593.1NP_001276522.1  kynureninase isoform 2

      See identical proteins and their annotated locations for NP_001276522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a 3' terminal exon which extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK050024, AK149423, AL845160
      Consensus CDS
      CCDS79792.1
      UniProtKB/Swiss-Prot
      Q9CXF0
      UniProtKB/TrEMBL
      Q6NSV5
      Related
      ENSMUSP00000108445.2, ENSMUST00000112826.8
      Conserved Domains (2) summary
      TIGR01814
      Location:31426
      kynureninase; kynureninase
      cl18945
      Location:25426
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    2. NM_001289594.1NP_001276523.1  kynureninase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK050024, AK149423, AL845336
      Consensus CDS
      CCDS79791.1
      UniProtKB/Swiss-Prot
      Q9CXF0
      UniProtKB/TrEMBL
      A2ARD7
      Related
      ENSMUSP00000061775.7, ENSMUST00000050511.7
      Conserved Domains (1) summary
      cl18945
      Location:25303
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    3. NM_027552.2NP_081828.1  kynureninase isoform 1

      See identical proteins and their annotated locations for NP_081828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK014484, AK149423, AL845160
      Consensus CDS
      CCDS16018.1
      UniProtKB/Swiss-Prot
      Q9CXF0
      UniProtKB/TrEMBL
      A2ARD6
      Related
      ENSMUSP00000028223.3, ENSMUST00000028223.9
      Conserved Domains (1) summary
      TIGR01814
      Location:31460
      kynureninase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      43445270..43573060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498325.3XP_006498388.1  kynureninase isoform X1

      See identical proteins and their annotated locations for XP_006498388.1

      UniProtKB/Swiss-Prot
      Q9CXF0
      UniProtKB/TrEMBL
      A2ARD6
      Conserved Domains (1) summary
      TIGR01814
      Location:31460
      kynureninase
    2. XM_011239179.3XP_011237481.1  kynureninase isoform X3

      Conserved Domains (1) summary
      TIGR01814
      Location:31427
      kynureninase
    3. XM_011239178.1XP_011237480.1  kynureninase isoform X2

      Conserved Domains (1) summary
      TIGR01814
      Location:31436
      kynureninase
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