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    Plb1 phospholipase B1 [ Mus musculus (house mouse) ]

    Gene ID: 665270, updated on 5-Mar-2024

    Summary

    Official Symbol
    Plb1provided by MGI
    Official Full Name
    phospholipase B1provided by MGI
    Primary source
    MGI:MGI:1922406
    See related
    Ensembl:ENSMUSG00000029134 AllianceGenome:MGI:1922406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4632413E21Rik; 4930433E17Rik; 4930539A06Rik
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Acts upstream of or within positive regulation of acrosome reaction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in brush border membrane. Is expressed in diencephalon lateral wall mantle layer; hypothalamus mantle layer; lung; midbrain mantle layer; and telencephalon mantle layer. Orthologous to human PLB1 (phospholipase B1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 54.9), testis adult (RPKM 15.4) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Plb1 in Genome Data Viewer
    Location:
    5 B1; 5 17.33 cM
    Exon count:
    61
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (32390035..32521700)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32232691..32364356)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene within bgcn homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_12789 Neighboring gene predicted gene, 36783 Neighboring gene STARR-seq mESC enhancer starr_12790 Neighboring gene predicted gene, 36840 Neighboring gene STARR-seq mESC enhancer starr_12791 Neighboring gene STARR-seq mESC enhancer starr_12792 Neighboring gene STARR-seq mESC enhancer starr_12794 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12795 Neighboring gene protein phosphatase 1 catalytic subunit beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC40917

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lysophospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidyl phospholipase B activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinyl-palmitate esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables retinyl-palmitate esterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables triglyceride lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in diacylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylcholine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylethanolamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    phospholipase B1, membrane-associated
    Names
    PLB/LIP
    lysophospholipase
    phospholipase A2
    phospholipase B
    phospholipase B/lipase
    triacylglycerol lipase
    NP_001074876.1
    NP_084348.1
    NP_742159.1
    XP_006504110.1
    XP_006504111.1
    XP_006504112.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081407.1NP_001074876.1  phospholipase B1, membrane-associated isoform 1 precursor

      See identical proteins and their annotated locations for NP_001074876.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AC102372, AK087596, AK161095, BC119077
      Consensus CDS
      CCDS39060.1
      UniProtKB/Swiss-Prot
      Q0VEX7, Q3TTY0, Q9D4Y6
      Conserved Domains (1) summary
      cd01824
      Location:387681
      Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
    2. NM_030072.1NP_084348.1  phospholipase B1, membrane-associated isoform 2

      See identical proteins and their annotated locations for NP_084348.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has shorter N- and C-termini when compared to isoform 1.
      Source sequence(s)
      AK030142
      UniProtKB/Swiss-Prot
      Q3TTY0
      Related
      ENSMUST00000202886.4
      Conserved Domains (2) summary
      cd01824
      Location:292586
      Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
      cl01053
      Location:9226
      SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...
    3. NM_172147.2NP_742159.1  phospholipase B1, membrane-associated isoform 3

      See identical proteins and their annotated locations for NP_742159.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains only a small portion of the 3' end of variant 1 and uses a downstream start codon to encode a much shorter protein (isoform 3) when it is compared to isoform 1.
      Source sequence(s)
      AK087596
      UniProtKB/TrEMBL
      Q8K255
      Conserved Domains (1) summary
      cl01053
      Location:184
      SGNH_hydrolase; SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      32390035..32521700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504047.2XP_006504110.1  phospholipase B1, membrane-associated isoform X1

      See identical proteins and their annotated locations for XP_006504110.1

      UniProtKB/Swiss-Prot
      Q0VEX7, Q3TTY0, Q9D4Y6
      Related
      ENSMUSP00000144040.2, ENSMUST00000202220.4
      Conserved Domains (1) summary
      cd01824
      Location:387681
      Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
    2. XM_006504048.2XP_006504111.1  phospholipase B1, membrane-associated isoform X2

      Conserved Domains (1) summary
      cd01824
      Location:387681
      Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...
    3. XM_006504049.5XP_006504112.1  phospholipase B1, membrane-associated isoform X3

      Conserved Domains (1) summary
      cd01824
      Location:1273
      Phospholipase_B_like; Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and ...