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    Tspan2 tetraspanin 2 [ Mus musculus (house mouse) ]

    Gene ID: 70747, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tspan2provided by MGI
    Official Full Name
    tetraspanin 2provided by MGI
    Primary source
    MGI:MGI:1917997
    See related
    Ensembl:ENSMUSG00000027858 AllianceGenome:MGI:1917997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tspan-2; 6330415F13Rik; B230119D02Rik
    Summary
    Acts upstream of or within inflammatory response and nervous system development. Located in myelin sheath and plasma membrane. Is expressed in pituitary gland. Orthologous to human TSPAN2 (tetraspanin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 25.4), cerebellum adult (RPKM 22.1) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F2.2; 3 45.25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (102642086..102679626)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (102734770..102772310)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08577 Neighboring gene STARR-positive B cell enhancer ABC_E3456 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene predicted gene, 40112 Neighboring gene STARR-seq mESC enhancer starr_08578 Neighboring gene tetraspanin 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_08579 Neighboring gene STARR-positive B cell enhancer mm9_chr3:102608013-102608314 Neighboring gene thyroid stimulating hormone, beta subunit Neighboring gene synaptonemal complex protein 1 Neighboring gene STARR-seq mESC enhancer starr_08580 Neighboring gene predicted gene, 33866

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. de Monasterio-Schrader P, et al. Glia, 2013 Nov. PMID 24038504
    2. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Gobert RP, et al. Mol Cell Biol, 2009 Mar. PMID 19139271, Free PMC Article
    3. Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Wansleeben C, et al. Development, 2010 Apr. PMID 20215345
    4. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621
    5. Absence of canonical Smad signaling in ureteral and bladder mesenchyme causes ureteropelvic junction obstruction. Tripathi P, et al. J Am Soc Nephrol, 2012 Apr. PMID 22282597, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the activation of astrocytes and microglia was strongly enhanced in Tspan2(null) *Plp1(null) double-mutants compared with either single-mutant
      Title: Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within astrocyte development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within astrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within axon development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within microglia development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within microglia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myelination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraspanin-2
    Names
    tetraspan 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243132.1 → NP_001230061.1  tetraspanin-2 isoform 2

      See identical proteins and their annotated locations for NP_001230061.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC134871, AK020982, AK160479
      Consensus CDS
      CCDS57249.1
      UniProtKB/TrEMBL
      Q8C0C9, Q9D1X8
      Related
      ENSMUSP00000113803.2, ENSMUST00000119902.6
      Conserved Domains (2) summary
      cd03151
      Location:106 → 182
      CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:20 → 210
      Tetraspannin; Tetraspanin family

    2. NM_027533.3 → NP_081809.2  tetraspanin-2 isoform 1

      See identical proteins and their annotated locations for NP_081809.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC134871, AK018178, AK079560
      Consensus CDS
      CCDS17688.1
      UniProtKB/Swiss-Prot
      Q543K4, Q922J6, Q9D397
      UniProtKB/TrEMBL
      Q8C0C9
      Related
      ENSMUSP00000029451.6, ENSMUST00000029451.12
      Conserved Domains (2) summary
      cd03151
      Location:110 → 186
      CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10 → 214
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      102642086..102679626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922J6.1 GenPept UniProtKB/Swiss-Prot:Q922J6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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