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    Ubn1 ubinuclein 1 [ Mus musculus (house mouse) ]

    Gene ID: 170644, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ubn1provided by MGI
    Official Full Name
    ubinuclein 1provided by MGI
    Primary source
    MGI:MGI:1891307
    See related
    Ensembl:ENSMUSG00000039473 AllianceGenome:MGI:1891307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110029L11Rik; 2610108L02Rik
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in DNA replication-independent chromatin assembly. Predicted to act upstream of or within keratinocyte differentiation. Located in bicellular tight junction. Is expressed in eye; limb; and limb mesenchyme. Orthologous to human UBN1 (ubinuclein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 18.7), limb E14.5 (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A1; 16 2.49 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4867921..4904153)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5050057..5086289)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7426 Neighboring gene rogdi homolog Neighboring gene glyoxylate reductase 1 homolog (Arabidopsis) Neighboring gene STARR-positive B cell enhancer ABC_E1180 Neighboring gene predicted gene, 23483 Neighboring gene transmembrane protein 126A pseudogene Neighboring gene periplakin Neighboring gene SEC14-like lipid binding 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells. Xiong C, et al. BMC Biol, 2018 Oct 3. PMID 30285846, Free PMC Article
    2. The H3.3 chaperone Hira complex orchestrates oocyte developmental competence. Smith R, et al. Development, 2022 Mar 1. PMID 35112132, Free PMC Article
    3. Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. Aho S, et al. J Cell Biol, 2000 Mar 20. PMID 10725330, Free PMC Article
    4. Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos). Aho S, et al. Biol Cell, 2009 Jun. PMID 18823282
    5. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. Phan LK, et al. J Clin Invest, 2002 Nov. PMID 12438443, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrates that the UBN1 or UBN2 subunit is mainly responsible for specific recognition and direct binding of H3.3 by the HIRA complex.
      Title: UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells.
    2. In mouse epithelia, including bile canaliculi, bronchioli, salivary gland ducts, and oral and olfactory epithelium, ubinuclein co-localized with tight junction markers
      Title: Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102206

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within keratinocyte differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubinuclein-1
    Names
    ubiquitously expressed nuclear protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356320.2 → NP_001343249.1  ubinuclein-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163723
      Consensus CDS
      CCDS88873.1
      Related
      ENSMUSP00000155263.2, ENSMUST00000229126.2
      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 573
      UBN_AB; Ubinuclein conserved middle domain

    2. NM_026666.4 → NP_080942.1  ubinuclein-1 isoform 1

      See identical proteins and their annotated locations for NP_080942.1

      Status: VALIDATED

      Source sequence(s)
      AK019173, AK147571, CJ246723
      Consensus CDS
      CCDS27931.1
      UniProtKB/Swiss-Prot
      Q3UUZ4, Q4G0F8, Q6P9K7, Q8BNC3, Q9CRM4, Q9CS40
      Related
      ENSMUSP00000061843.6, ENSMUST00000052449.6
      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 573
      UBN_AB; Ubinuclein conserved middle domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4867921..4904153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521817.4 → XP_006521880.1  ubinuclein-1 isoform X3

      See identical proteins and their annotated locations for XP_006521880.1

      UniProtKB/Swiss-Prot
      Q3UUZ4, Q4G0F8, Q6P9K7, Q8BNC3, Q9CRM4, Q9CS40
      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 573
      UBN_AB; Ubinuclein conserved middle domain

    2. XM_006521816.4 → XP_006521879.1  ubinuclein-1 isoform X3

      See identical proteins and their annotated locations for XP_006521879.1

      UniProtKB/Swiss-Prot
      Q3UUZ4, Q4G0F8, Q6P9K7, Q8BNC3, Q9CRM4, Q9CS40
      Related
      ENSMUSP00000155223.2, ENSMUST00000230703.2
      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 573
      UBN_AB; Ubinuclein conserved middle domain

    3. XM_036159802.1 → XP_036015695.1  ubinuclein-1 isoform X1

      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 606
      UBN_AB; Ubinuclein conserved middle domain

    4. XM_036159798.1 → XP_036015691.1  ubinuclein-1 isoform X1

      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 606
      UBN_AB; Ubinuclein conserved middle domain

    5. XM_036159797.1 → XP_036015690.1  ubinuclein-1 isoform X1

      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 606
      UBN_AB; Ubinuclein conserved middle domain

    6. XM_036159804.1 → XP_036015697.1  ubinuclein-1 isoform X2

      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 606
      UBN_AB; Ubinuclein conserved middle domain

    7. XM_036159800.1 → XP_036015693.1  ubinuclein-1 isoform X1

      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 606
      UBN_AB; Ubinuclein conserved middle domain

    8. XM_036159799.1 → XP_036015692.1  ubinuclein-1 isoform X1

      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 606
      UBN_AB; Ubinuclein conserved middle domain

    9. XM_036159801.1 → XP_036015694.1  ubinuclein-1 isoform X1

      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 606
      UBN_AB; Ubinuclein conserved middle domain

    10. XM_036159803.1 → XP_036015696.1  ubinuclein-1 isoform X1

      Conserved Domains (2) summary
      pfam08729
      Location:117 → 168
      HUN; HPC2 and ubinuclein domain
      pfam14075
      Location:354 → 606
      UBN_AB; Ubinuclein conserved middle domain

    11. XM_036159805.1 → XP_036015698.1  ubinuclein-1 isoform X4

      Conserved Domains (1) summary
      pfam14075
      Location:1 → 118
      UBN_AB; Ubinuclein conserved middle domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G0F8.1 GenPept UniProtKB/Swiss-Prot:Q4G0F8

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