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    Garre1 granule associated Rac and RHOG effector 1 [ Mus musculus (house mouse) ]

    Gene ID: 233103, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Garre1provided by MGI
    Official Full Name
    granule associated Rac and RHOG effector 1provided by MGI
    Primary source
    MGI:MGI:1924311
    See related
    Ensembl:ENSMUSG00000066571 AllianceGenome:MGI:1924311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0355; 4931406P16Rik
    Summary
    Predicted to enable CCR4-NOT complex binding activity and small GTPase binding activity. Predicted to be involved in Rac protein signal transduction. Predicted to be located in P-body. Is expressed in lung and ovary. Orthologous to human GARRE1 (granule associated Rac and RHOG effector 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 32.6), ovary adult (RPKM 21.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Garre1 in Genome Data Viewer
    Location:
    7 B1; 7 19.48 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (33936132..34012990, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34236707..34313554, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glucose-6-phosphate isomerase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8163 Neighboring gene STARR-seq mESC enhancer starr_18586 Neighboring gene predicted gene 12762 Neighboring gene predicted gene 12758 Neighboring gene VISTA enhancer mm1379 Neighboring gene STARR-seq mESC enhancer starr_18591 Neighboring gene LSM14A mRNA processing body assembly factor Neighboring gene 39S ribosomal protein L27, mitochondrial pseudogene Neighboring gene predicted gene 12764

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR4-NOT complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CCR4-NOT complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    granule associated Rac and RHOG effector protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382305.1 → NP_001369234.1  granule associated Rac and RHOG effector protein 1

      Status: VALIDATED

      Source sequence(s)
      BX537302
      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Related
      ENSMUSP00000103709.2, ENSMUST00000108074.8
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    2. NM_172741.3 → NP_766329.1  granule associated Rac and RHOG effector protein 1

      See identical proteins and their annotated locations for NP_766329.1

      Status: VALIDATED

      Source sequence(s)
      BX537302
      Consensus CDS
      CCDS21139.1
      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Related
      ENSMUSP00000082730.5, ENSMUST00000085592.6
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      33936132..34012990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539896.4 → XP_006539959.1  granule associated Rac and RHOG effector protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006539959.1

      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    2. XM_030242461.1 → XP_030098321.1  granule associated Rac and RHOG effector protein 1 isoform X1

      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    3. XM_006539895.2 → XP_006539958.1  granule associated Rac and RHOG effector protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006539958.1

      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Related
      ENSMUSP00000145762.2, ENSMUST00000206399.2
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    4. XM_030242458.2 → XP_030098318.1  granule associated Rac and RHOG effector protein 1 isoform X1

      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    5. XM_006539897.3 → XP_006539960.1  granule associated Rac and RHOG effector protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006539960.1

      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    6. XM_030242462.1 → XP_030098322.1  granule associated Rac and RHOG effector protein 1 isoform X1

      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    7. XM_030242459.1 → XP_030098319.1  granule associated Rac and RHOG effector protein 1 isoform X1

      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    8. XM_030242460.2 → XP_030098320.1  granule associated Rac and RHOG effector protein 1 isoform X1

      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)

    9. XM_006539899.5 → XP_006539962.1  granule associated Rac and RHOG effector protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006539962.1

      UniProtKB/TrEMBL
      Q6PAL5, Q8C5X1
      Conserved Domains (1) summary
      pfam15923
      Location:59 → 187
      DUF4745; Domain of unknown function (DUF4745)
    Nucleotide Protein Strain
    Heading Accession and Version

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