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    Ablim3 actin binding LIM protein family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 319713, updated on 5-Sep-2021

    Summary

    Official Symbol
    Ablim3provided by MGI
    Official Full Name
    actin binding LIM protein family, member 3provided by MGI
    Primary source
    MGI:MGI:2442582
    See related
    Ensembl:ENSMUSG00000032735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW990719; D930036B08Rik
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 16.1), CNS E18 (RPKM 14.9) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ablim3 in Genome Data Viewer
    Location:
    18; 18 E1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61932463..62044956, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61799392..61911885, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (61959046..62071506, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500015A07 gene Neighboring gene GrpE-like 2, mitochondrial Neighboring gene actin filament associated protein 1-like 1 Neighboring gene predicted gene, 41748 Neighboring gene predicted gene, 35919 Neighboring gene predicted gene, 35720 Neighboring gene SH3 domain and tetratricopeptide repeats 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0843, MGC69876

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    actin-binding LIM protein 3
    Names
    abLIM-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164491.1NP_001157963.1  actin-binding LIM protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001157963.1

      Status: VALIDATED

      Source sequence(s)
      AC091677, BC060275, CF171696
      Consensus CDS
      CCDS37839.1
      UniProtKB/Swiss-Prot
      Q69ZX8
      Related
      ENSMUSP00000125836.2, ENSMUST00000166783.3
      Conserved Domains (6) summary
      smart00153
      Location:647682
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273645
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    2. NM_001360868.1NP_001347797.1  actin-binding LIM protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC091677, AC125157
      Conserved Domains (6) summary
      smart00153
      Location:614649
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273612
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    3. NM_198649.3NP_941051.2  actin-binding LIM protein 3 isoform 1

      See identical proteins and their annotated locations for NP_941051.2

      Status: VALIDATED

      Source sequence(s)
      AC091677, BC094229
      Consensus CDS
      CCDS37839.1
      UniProtKB/Swiss-Prot
      Q69ZX8
      Related
      ENSMUSP00000041243.9, ENSMUST00000049378.15
      Conserved Domains (6) summary
      smart00153
      Location:647682
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273645
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61932463..62044956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250507.2XP_030106367.1  actin-binding LIM protein 3 isoform X7

      Conserved Domains (6) summary
      smart00153
      Location:536571
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273534
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    2. XM_030250506.1XP_030106366.1  actin-binding LIM protein 3 isoform X4

      Conserved Domains (6) summary
      smart00153
      Location:598633
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273596
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    3. XM_036161169.1XP_036017062.1  actin-binding LIM protein 3 isoform X2

      Conserved Domains (6) summary
      smart00153
      Location:631666
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273630
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    4. XM_006526006.5XP_006526069.1  actin-binding LIM protein 3 isoform X2

      Conserved Domains (6) summary
      smart00153
      Location:631666
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273630
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    5. XM_006526005.5XP_006526068.1  actin-binding LIM protein 3 isoform X1

      Conserved Domains (6) summary
      smart00153
      Location:637672
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273635
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    6. XM_006526010.5XP_006526073.1  actin-binding LIM protein 3 isoform X6

      Conserved Domains (6) summary
      smart00153
      Location:552587
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273550
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    7. XM_006526009.5XP_006526072.1  actin-binding LIM protein 3 isoform X5

      Conserved Domains (6) summary
      smart00153
      Location:585620
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273583
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    8. XM_006526008.5XP_006526071.1  actin-binding LIM protein 3 isoform X4

      Conserved Domains (6) summary
      smart00153
      Location:598633
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273596
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    9. XM_006526007.5XP_006526070.1  actin-binding LIM protein 3 isoform X3

      Conserved Domains (6) summary
      smart00153
      Location:614649
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:151202
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:210265
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273612
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    10. XM_030250508.1XP_030106368.1  actin-binding LIM protein 3 isoform X8

      Conserved Domains (4) summary
      smart00153
      Location:511546
      VHP; Villin headpiece domain
      cd09329
      Location:1566
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:74129
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:137509
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    11. XM_006526012.2XP_006526075.1  actin-binding LIM protein 3 isoform X9

      Conserved Domains (3) summary
      smart00153
      Location:408443
      VHP; Villin headpiece domain
      cl02475
      Location:1226
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:34406
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
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