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    Tubgcp6 tubulin, gamma complex component 6 [ Mus musculus (house mouse) ]

    Gene ID: 328580, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tubgcp6provided by MGI
    Official Full Name
    tubulin, gamma complex component 6provided by MGI
    Primary source
    MGI:MGI:2146071
    See related
    Ensembl:ENSMUSG00000051786 AllianceGenome:MGI:2146071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCP-6; mKIAA1669; D430023H11
    Summary
    Predicted to enable gamma-tubulin binding activity and microtubule binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be part of gamma-tubulin large complex and gamma-tubulin small complex. Predicted to be active in centrosome and equatorial microtubule organizing center. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 1. Orthologous to human TUBGCP6 (tubulin gamma complex associated protein 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.9), genital fat pad adult (RPKM 11.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E3; 15 44.61 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (88983300..89007411, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89099097..89123208, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene pannexin 2 Neighboring gene RIKEN cDNA 1810021B22 gene Neighboring gene TraB domain containing Neighboring gene selenoprotein O Neighboring gene STARR-positive B cell enhancer ABC_E5508 Neighboring gene histone deacetylase 10 Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. Ansseau E, et al. PLoS One, 2016. PMID 26816005, Free PMC Article
    2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in equatorial microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin ring complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-tubulin complex component 6
    Names
    tubulin, gamma complex associated protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163319.1 → NP_001156791.1  gamma-tubulin complex component 6

      See identical proteins and their annotated locations for NP_001156791.1

      Status: VALIDATED

      Source sequence(s)
      AK052293, AK052441, BC057626, CF536834, CJ120677, CK637726
      Consensus CDS
      CCDS49697.1
      UniProtKB/Swiss-Prot
      G5E8P0, Q6PFC6, Q6ZPK3, Q8BWI2
      UniProtKB/TrEMBL
      E9Q6P4
      Related
      ENSMUSP00000104977.3, ENSMUST00000109353.9
      Conserved Domains (5) summary
      pfam09528
      Location:672 → 1249
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      pfam04130
      Location:355 → 611
      Spc97_Spc98; Spc97 / Spc98 family
      pfam08537
      Location:622 → 752
      NBP1; Fungal Nap binding protein NBP1
      pfam13863
      Location:689 → 785
      DUF4200; Domain of unknown function (DUF4200)
      pfam15346
      Location:631 → 759
      ARGLU; Arginine and glutamate-rich 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      88983300..89007411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159469.1 → XP_036015362.1  gamma-tubulin complex component 6 isoform X2

      Conserved Domains (3) summary
      pfam04130
      Location:946 → 1246
      Spc97_Spc98; Spc97 / Spc98 family
      pfam13868
      Location:137 → 292
      TPH; Trichohyalin-plectin-homology domain
      pfam17681
      Location:13 → 89
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    2. XM_006521093.2 → XP_006521156.1  gamma-tubulin complex component 6 isoform X1

      UniProtKB/TrEMBL
      E9Q6P4
      Conserved Domains (3) summary
      pfam04130
      Location:1466 → 1492
      Spc97_Spc98; Spc97 / Spc98 family
      pfam13868
      Location:645 → 815
      TPH; Trichohyalin-plectin-homology domain
      pfam17681
      Location:353 → 613
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    RNA

    1. XR_384017.3 RNA Sequence

    2. XR_384016.3 RNA Sequence

    3. XR_001781546.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5E8P0.1 GenPept UniProtKB/Swiss-Prot:G5E8P0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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