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    Lrrcc1 leucine rich repeat and coiled-coil domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 71710, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lrrcc1provided by MGI
    Official Full Name
    leucine rich repeat and coiled-coil domain containing 1provided by MGI
    Primary source
    MGI:MGI:1918960
    See related
    Ensembl:ENSMUSG00000027550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI195358; AI447421; 1200008A14Rik; 4932441F23Rik
    Expression
    Broad expression in testis adult (RPKM 4.8), CNS E11.5 (RPKM 3.7) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lrrcc1 in Genome Data Viewer
    Location:
    3; 3 A1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (14595512..14637718)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (14533762..14572658)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (14533788..14572658)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 12 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene E2F transcription factor 5 Neighboring gene ribosomal biogenesis factor Neighboring gene predicted gene, 54191

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC106275

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat and coiled-coil domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163579.1NP_001157051.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001157051.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC140350, BC138734
      Consensus CDS
      CCDS50866.1
      UniProtKB/Swiss-Prot
      Q69ZB0
      UniProtKB/TrEMBL
      G5E8Y2
      Related
      ENSMUSP00000126560.2, ENSMUST00000169079.8
      Conserved Domains (9) summary
      COG0419
      Location:421952
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG4886
      Location:30115
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:4361
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:158188
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:61101
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:82142
      LRR_8; Leucine rich repeat
      pfam15665
      Location:7931026
      FAM184; Family with sequence similarity 184, A and B
      cl00240
      Location:915969
      RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
      cl19219
      Location:817894
      DUF342; Protein of unknown function (DUF342)
    2. NM_001163580.1NP_001157052.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC140350, BC138734
      Consensus CDS
      CCDS50865.1
      UniProtKB/Swiss-Prot
      Q69ZB0
      UniProtKB/TrEMBL
      E9QNC6
      Related
      ENSMUSP00000088875.4, ENSMUST00000091325.10
      Conserved Domains (9) summary
      COG0419
      Location:405936
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG4886
      Location:30115
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:4361
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:158188
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:61101
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:82142
      LRR_8; Leucine rich repeat
      pfam15665
      Location:7771010
      FAM184; Family with sequence similarity 184, A and B
      cl00240
      Location:899953
      RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
      cl19219
      Location:801878
      DUF342; Protein of unknown function (DUF342)
    3. NM_028915.3NP_083191.2  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_083191.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC140350, AI646154, BC138734
      Consensus CDS
      CCDS38390.1
      UniProtKB/Swiss-Prot
      Q69ZB0
      UniProtKB/TrEMBL
      B9EI20
      Related
      ENSMUSP00000104007.3, ENSMUST00000108370.9
      Conserved Domains (8) summary
      COG4886
      Location:30115
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:4361
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:158188
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:61101
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:82142
      LRR_8; Leucine rich repeat
      pfam15665
      Location:793981
      FAM184; Family with sequence similarity 184, A and B
      cl00240
      Location:915969
      RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
      cl19219
      Location:817894
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      14595512..14637718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163334.1XP_036019227.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      COG0419
      Location:299830
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd21340
      Location:275
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    2. XM_030252826.1XP_030108686.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      COG0419
      Location:340871
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      sd00031
      Location:2550
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:2491
      LRR_8; Leucine rich repeat
    3. XM_006530089.3XP_006530152.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      COG0419
      Location:340871
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      sd00031
      Location:2550
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:2491
      LRR_8; Leucine rich repeat
    4. XM_036163333.1XP_036019226.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      COG0419
      Location:324855
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      sd00031
      Location:2550
      LRR_1; leucine-rich repeat [structural motif]
      cd21340
      Location:25116
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    5. XM_006530090.4XP_006530153.1  leucine-rich repeat and coiled-coil domain-containing protein 1 isoform X5

      Related
      ENSMUSP00000129368.2, ENSMUST00000167858.8
      Conserved Domains (2) summary
      COG1196
      Location:400653
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:65637
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_003954391.2 RNA Sequence

    2. XR_004941396.1 RNA Sequence

    3. XR_387522.5 RNA Sequence

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