Gbp2 guanylate binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gbp2provided by MGI
Official Full Name: guanylate binding protein 2provided by MGI
Primary source: MGI:MGI:102772
See related: Ensembl:ENSMUSG00000028270 AllianceGenome:MGI:102772
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including Hsp90 protein binding activity; cytoskeletal protein binding activity; and guanyl ribonucleotide binding activity. Acts upstream of or within several processes, including cellular response to interferon-beta; cellular response to lipopolysaccharide; and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to several human genes including GBP2 (guanylate binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 40.7), subcutaneous fat pad adult (RPKM 15.6) and 13 other tissues See more
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Genomic context

Location:: 3 H1; 3 66.69 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (142326424..142343769)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (142620663..142638008)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Ppargamma-CD36 axis.
Title: Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.
Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2.
Title: Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2.
Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.
Title: Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.
Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.
Title: Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.
Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.
Title: Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.
high-affinity T cells sustained IL-2R expression longer and expressed two novel Th cell differentiation regulators, Eef1e1 and Gbp2, to a higher level than low-affinity T cells.
Title: TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
GBP2 can effectively regulate beta-glucan-induced maturation of DCs, thus suppressing the proliferation of T cells.
Title: [Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan].
This study demonstrated that Gbeta2 is important for neuronal migration, especially in the multipolar-bipolar transition.
Title: Gβ2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex.
GBP1 GBP2 enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
Title: Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
this study identified guanylate-binding proteins GBP2 and GBP5 as key activators of AIM2 during infection with F. novicida.
Title: Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF077007 (e-PCR)
- UniSTS:163334

Gbp2 (e-PCR), detects polymorphism
- UniSTS:506929

Gbp2 (e-PCR), detects polymorphism
- UniSTS:143182

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables G protein activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables GTPase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adhesion of symbiont to host	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in cytolysis in another organism	IDA Inferred from Direct Assay more info	PubMed
involved_in cytolysis in another organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to protozoan	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of AIM2 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of pyroptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of pyroptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in symbiont cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in symbiont cell surface	ISO Inferred from Sequence Orthology more info
located_in symbiont-containing vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanylate-binding protein 2

Names: GBP-2; GTP-binding protein 2; guanine nucleotide-binding protein 2; guanylate nucleotide binding protein 2; guanylate-binding protein 1; interferon-induced guanylate-binding protein 2; mGBP-2; mGBP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010260.1 → NP_034390.1 guanylate-binding protein 2

See identical proteins and their annotated locations for NP_034390.1

Status: PROVISIONAL

Source sequence(s)

AF077007

Consensus CDS

CCDS17880.1

UniProtKB/Swiss-Prot

Q4FK03, Q8CIC6, Q921N2, Q9R1I0, Q9Z0E6

UniProtKB/TrEMBL

Q3UDC7

Related

ENSMUSP00000132435.2, ENSMUST00000165774.8

Conserved Domains (3) summary

pfam02841
Location:282 → 578

GBP_C; Guanylate-binding protein, C-terminal domain

pfam02263
Location:18 → 280

GBP; Guanylate-binding protein, N-terminal domain

cd16269
Location:288 → 578

GBP_C; Guanylate-binding protein, C-terminal domain