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    Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 13688, updated on 11-Apr-2024

    Summary

    Official Symbol
    Eif4ebp2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 2provided by MGI
    Primary source
    MGI:MGI:109198
    See related
    Ensembl:ENSMUSG00000020091 AllianceGenome:MGI:109198
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4E-BP2; PHAS-II; 2810011I19Rik
    Summary
    Enables eukaryotic initiation factor 4E binding activity and translation repressor activity. Involved in several processes, including memory; negative regulation of translational initiation; and social behavior. Acts upstream of or within TOR signaling and insulin receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in heart; liver; and lung. Used to study autism spectrum disorder. Orthologous to human EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 49.7), liver adult (RPKM 46.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    10 B4; 10 32.21 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61268276..61288448, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61428491..61452790, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26836 Neighboring gene phosphatase domain containing, paladin 1 Neighboring gene STARR-seq mESC enhancer starr_26839 Neighboring gene STARR-seq mESC enhancer starr_26844 Neighboring gene nodal growth differentiation factor Neighboring gene STARR-positive B cell enhancer ABC_E3888 Neighboring gene STARR-seq mESC enhancer starr_26847 Neighboring gene RIKEN cDNA D830039M14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6860 Neighboring gene leucine rich repeat containing 20 Neighboring gene predicted gene, 47593

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC141219

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables eukaryotic initiation factor 4E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables eukaryotic initiation factor 4E binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in intracellular non-membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 2
    Names
    eIF4E-binding protein 2
    phosphorylated heat- and acid-stable protein regulated by insulin 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010124.2NP_034254.1  eukaryotic translation initiation factor 4E-binding protein 2

      See identical proteins and their annotated locations for NP_034254.1

      Status: PROVISIONAL

      Source sequence(s)
      AC122197
      Consensus CDS
      CCDS23879.1
      UniProtKB/Swiss-Prot
      P70445
      UniProtKB/TrEMBL
      Q3UFP6, Q3UZD4
      Related
      ENSMUSP00000020288.8, ENSMUST00000020288.15
      Conserved Domains (1) summary
      pfam05456
      Location:13120
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      61268276..61288448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)