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    Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 [ Mus musculus (house mouse) ]

    Gene ID: 114479, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc5a5provided by MGI
    Official Full Name
    solute carrier family 5 (sodium iodide symporter), member 5provided by MGI
    Primary source
    MGI:MGI:2149330
    See related
    Ensembl:ENSMUSG00000000792 AllianceGenome:MGI:2149330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NIS
    Summary
    Enables sodium:iodide symporter activity. Predicted to be involved in iodide transmembrane transport and sodium ion transport. Predicted to act upstream of or within ion transport. Predicted to be located in nucleus. Predicted to be active in plasma membrane. Is expressed in axial skeleton tail region; stomach; testis; and thyroid gland. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 130.4) and mammary gland adult (RPKM 64.6) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B3.3; 8 34.36 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71335529..71345429, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70882885..70892785, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E3780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73389712-73389895 Neighboring gene coiled-coil domain containing 124 Neighboring gene STARR-positive B cell enhancer ABC_E8242 Neighboring gene STARR-seq mESC enhancer starr_21801 Neighboring gene ribosomal protein L18A Neighboring gene microRNA 7067 Neighboring gene small nucleolar RNA, H/ACA box 68

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene. Hickey RD, et al. Liver Transpl, 2015 Apr. PMID 25482651, Free PMC Article
    2. Targeted radioiodine therapy of neuroblastoma tumors following systemic nonviral delivery of the sodium iodide symporter gene. Klutz K, et al. Clin Cancer Res, 2009 Oct 1. PMID 19789324
    3. Cloning of the mouse sodium iodide symporter. Pinke LA, et al. Thyroid, 2001 Oct. PMID 11716040
    4. The paradoxical lean phenotype of hypothyroid mice is marked by increased adaptive thermogenesis in the skeletal muscle. Kaspari RR, et al. Proc Natl Acad Sci U S A, 2020 Sep 8. PMID 32826330, Free PMC Article
    5. Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. Ferrandino G, et al. Proc Natl Acad Sci U S A, 2017 Oct 24. PMID 29073114, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using Slc5a5 transgenic mice.
      Title: Noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene.
    2. High potential of novel pseudodendritic polymers for tumor-specific NIS gene delivery after systemic application, opening the prospect of targeted NIS-mediated radionuclide therapy of nonthyroidal tumors even in metastatic disease.
      Title: Targeted radioiodine therapy of neuroblastoma tumors following systemic nonviral delivery of the sodium iodide symporter gene.
    3. The Na+/I- symporter mediates active iodide uptake in the intestine.
      Title: The Na+/I- symporter mediates active iodide uptake in the intestine.
    4. This study represents a promising first step in investigations of the potential use of a combination of the NIS gene and MDR1 shRNA as a new therapeutic strategy allowing RNA interference-based gene therapy.
      Title: Combination therapy and noninvasive imaging with a dual therapeutic vector expressing MDR1 short hairpin RNA and a sodium iodide symporter.
    5. Cloning of the mouse sodium iodide symporter.
      Title: Cloning of the mouse sodium iodide symporter.
    6. The high degree of homology in the 5'-flanking region between mouse and rat NIS suggests that mNIS and rNIS share similar mechanisms for transcriptional regulation in the thyroid.
      Title: Cloning of the 5'-flanking region of mouse sodium/iodide symporter and identification of a thyroid-specific and TSH-responsive enhancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables iodide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic anion:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium:iodide symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:iodide symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:iodide symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to Thyroid stimulating hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to forskolin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iodide transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iodide transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within iodide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in iodide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within monoatomic anion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium/iodide cotransporter
    Names
    Na(+)/I(-) cotransporter
    Na(+)/I(-) symporter
    sodium-iodide symporter
    solute carrier family 5 member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053248.2 → NP_444478.2  sodium/iodide cotransporter

      See identical proteins and their annotated locations for NP_444478.2

      Status: VALIDATED

      Source sequence(s)
      AC019302, AK046718, BB645718, CD741961
      Consensus CDS
      CCDS22385.1
      UniProtKB/Swiss-Prot
      B2RPX6, Q99PN0
      UniProtKB/TrEMBL
      G3X8P5
      Related
      ENSMUSP00000000809.3, ENSMUST00000000809.3
      Conserved Domains (1) summary
      cd11503
      Location:15 → 549
      SLC5sbd_NIS; Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71335529..71345429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509537.4 → XP_006509600.1  sodium/iodide cotransporter isoform X1

      UniProtKB/Swiss-Prot
      B2RPX6, Q99PN0
      Conserved Domains (1) summary
      cl00456
      Location:15 → 527
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. XR_870460.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PN0.1 GenPept UniProtKB/Swiss-Prot:Q99PN0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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