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    Ptpn14 protein tyrosine phosphatase, non-receptor type 14 [ Mus musculus (house mouse) ]

    Gene ID: 19250, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ptpn14provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 14provided by MGI
    Primary source
    MGI:MGI:102467
    See related
    Ensembl:ENSMUSG00000026604 AllianceGenome:MGI:102467
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PTP36; C130080N23Rik
    Summary
    Predicted to enable protein tyrosine phosphatase activity; receptor tyrosine kinase binding activity; and transcription coregulator activity. Involved in lymphangiogenesis. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; musculoskeletal system; and sensory organ. Orthologous to human PTPN14 (protein tyrosine phosphatase non-receptor type 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 7.4), lung adult (RPKM 7.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H6; 1 95.03 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (189460417..189608892)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (189728216..189876695)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3351 Neighboring gene predicted gene, 30088 Neighboring gene centromere protein F Neighboring gene STARR-positive B cell enhancer ABC_E802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:191524821-191525121 Neighboring gene STARR-seq mESC enhancer starr_03400 Neighboring gene STARR-seq mESC enhancer starr_03401 Neighboring gene STARR-seq mESC enhancer starr_03402 Neighboring gene predicted gene, 51739 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191627745-191627946 Neighboring gene STARR-seq mESC enhancer starr_03406 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191654884-191655189 Neighboring gene STARR-seq mESC enhancer starr_03408 Neighboring gene STARR-seq mESC enhancer starr_03409 Neighboring gene predicted gene, 30280 Neighboring gene predicted gene, 26574 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191691042-191691151 Neighboring gene STARR-seq mESC enhancer starr_03412 Neighboring gene SET and MYND domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_03413 Neighboring gene STARR-positive B cell enhancer mm9_chr1:191796963-191797263 Neighboring gene predicted gene, 39736

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease. Romero-Masters JC, et al. PLoS Pathog, 2023 Apr. PMID 37036883, Free PMC Article
    2. The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking. Belle L, et al. Sci Signal, 2015 Feb 17. PMID 25690013
    3. Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36. Aoyama K, et al. Biochem Biophys Res Commun, 1999 Dec 20. PMID 10600535
    4. cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells. Sawada M, et al. Biochem Biophys Res Commun, 1994 Aug 30. PMID 8074693
    5. PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy. Lin Y, et al. Biochem Biophys Res Commun, 2021 Apr 23. PMID 33684622

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease.
      Title: MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease.
    2. PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy.
      Title: PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy.
    3. PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure.
      Title: PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure.
    4. Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation.
      Title: Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation.
    5. The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis.
      Title: The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis.
    6. The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
      Title: The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.
    7. PTPN14 has a role in angiogenesis and/or arteriovenous fate, acting via EphrinB2 and ACVRL1/activin receptor-like kinase 1
      Title: Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2) 
    • Endonuclease-mediated (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lymphangiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lymphangiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 14
    Names
    protein-tyrosine phosphatase PTP36
    NP_033002.2
    XP_006497192.1
    XP_006497194.1
    XP_006497196.1
    XP_006497197.1
    XP_030108157.1
    XP_036018685.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008976.2 → NP_033002.2  tyrosine-protein phosphatase non-receptor type 14

      See identical proteins and their annotated locations for NP_033002.2

      Status: VALIDATED

      Source sequence(s)
      AC140250, AC140461, AK037646, AK136544, BB663191, CK780322, DV552967
      Consensus CDS
      CCDS15609.1
      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Related
      ENSMUSP00000095051.3, ENSMUST00000097442.9
      Conserved Domains (3) summary
      smart00295
      Location:24 → 220
      B41; Band 4.1 homologues
      cd13188
      Location:215 → 305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:898 → 1184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      189460417..189608892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497134.4 → XP_006497197.1  tyrosine-protein phosphatase non-receptor type 14 isoform X2

      Conserved Domains (3) summary
      cd13188
      Location:116 → 206
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:799 → 1085
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
      pfam00373
      Location:6 → 121
      FERM_M; FERM central domain

    2. XM_036162792.1 → XP_036018685.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Conserved Domains (3) summary
      smart00295
      Location:24 → 220
      B41; Band 4.1 homologues
      cd13188
      Location:215 → 305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:898 → 1184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

    3. XM_006497131.5 → XP_006497194.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      See identical proteins and their annotated locations for XP_006497194.1

      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Conserved Domains (3) summary
      smart00295
      Location:24 → 220
      B41; Band 4.1 homologues
      cd13188
      Location:215 → 305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:898 → 1184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

    4. XM_030252297.2 → XP_030108157.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Conserved Domains (3) summary
      smart00295
      Location:24 → 220
      B41; Band 4.1 homologues
      cd13188
      Location:215 → 305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:898 → 1184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

    5. XM_006497129.5 → XP_006497192.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      See identical proteins and their annotated locations for XP_006497192.1

      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Conserved Domains (3) summary
      smart00295
      Location:24 → 220
      B41; Band 4.1 homologues
      cd13188
      Location:215 → 305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:898 → 1184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

    6. XM_006497133.5 → XP_006497196.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      See identical proteins and their annotated locations for XP_006497196.1

      UniProtKB/Swiss-Prot
      G5E8M1, Q62130
      UniProtKB/TrEMBL
      Q8CAV9
      Conserved Domains (3) summary
      smart00295
      Location:24 → 220
      B41; Band 4.1 homologues
      cd13188
      Location:215 → 305
      FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
      cd14599
      Location:898 → 1184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033287.1: Suppressed sequence

      Description
      NM_001033287.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62130.2 GenPept UniProtKB/Swiss-Prot:Q62130

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