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    Lrch2 leucine-rich repeats and calponin homology (CH) domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 210297, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Lrch2provided by MGI
    Official Full Name
    leucine-rich repeats and calponin homology (CH) domain containing 2provided by MGI
    Primary source
    MGI:MGI:2147870
    See related
    Ensembl:ENSMUSG00000031290 AllianceGenome:MGI:2147870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1495
    Summary
    Is expressed in adrenal cortex; central nervous system; skeletal musculature; and urinary system. Orthologous to human LRCH2 (leucine rich repeats and calponin homology domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E14 (RPKM 6.4), whole brain E14.5 (RPKM 6.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X F2; X 68.46 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (146253376..146337198, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (147470375..147554103, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene interleukin 13 receptor, alpha 2 Neighboring gene vomeronasal 1 receptor 239, pseudogene Neighboring gene predicted gene, 25107 Neighboring gene STARR-seq mESC enhancer starr_48058 Neighboring gene vomeronasal 2, receptor 121 pseudogene Neighboring gene predicted gene 8289

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of Prl7d1 causes placental defects at mid-pregnancy in mice. Zhang Q, et al. Mol Reprod Dev, 2019 Jun. PMID 31012985
    2. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
    3. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    4. Identification of 14-3-3epsilon substrates from embryonic murine brain. Ballif BA, et al. J Proteome Res, 2006 Sep. PMID 16944949
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and calponin homology domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081173.3 → NP_001074642.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001074642.1

      Status: VALIDATED

      Source sequence(s)
      AL671981, AL807780
      Consensus CDS
      CCDS41160.1
      UniProtKB/Swiss-Prot
      A2AMN8, Q3UMG5, Q7TNP9, Q80TC9
      UniProtKB/TrEMBL
      F6VQ19
      Related
      ENSMUSP00000108438.3, ENSMUST00000112819.9
      Conserved Domains (5) summary
      cd00116
      Location:144 → 245
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:100 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00307
      Location:652 → 759
      CH; Calponin homology (CH) domain
      pfam12799
      Location:144 → 181
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:189 → 245
      LRR_8; Leucine rich repeat

    2. NM_001356368.2 → NP_001343297.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671981, AL807780
      UniProtKB/TrEMBL
      F6VQ19
      Conserved Domains (3) summary
      smart00033
      Location:667 → 756
      CH; Calponin homology domain
      sd00033
      Location:100 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      cl26018
      Location:76 → 290
      NEL; C-terminal novel E3 ligase, LRR-interacting

    3. NM_001356369.2 → NP_001343298.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL671981, AL807780
      Conserved Domains (3) summary
      smart00033
      Location:501 → 590
      CH; Calponin homology domain
      sd00033
      Location:26 → 48
      LRR_RI; leucine-rich repeat [structural motif]
      cl26018
      Location:7 → 172
      NEL; C-terminal novel E3 ligase, LRR-interacting

    4. NM_001403576.1 → NP_001390505.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL671981, AL807780

    5. NM_001403578.1 → NP_001390507.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL671981, AL807780

    6. NM_001403579.1 → NP_001390508.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL671981, AL807780

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      146253376..146337198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528790.5 → XP_006528853.3  leucine-rich repeat and calponin homology domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      F6VQ19
      Conserved Domains (3) summary
      PRK15370
      Location:101 → 315
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:125 → 145
      LRR_RI; leucine-rich repeat [structural motif]
      cd21271
      Location:659 → 769
      CH_LRCH2; calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 2

    2. XM_006528792.4 → XP_006528855.1  leucine-rich repeat and calponin homology domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      F6VQ19
      Conserved Domains (3) summary
      smart00033
      Location:566 → 655
      CH; Calponin homology domain
      COG4886
      Location:7 → 233
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:26 → 48
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UMG5.2 GenPept UniProtKB/Swiss-Prot:Q3UMG5

    Gene LinkOut

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