Tacr3 tachykinin receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tacr3provided by MGI
Official Full Name: tachykinin receptor 3provided by MGI
Primary source: MGI:MGI:892968
See related: Ensembl:ENSMUSG00000028172 AllianceGenome:MGI:892968
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nkr; Nk3r; Tac3r
Summary: This gene belongs to a family of genes that function as receptors for tachykinins. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Mar 2010]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 62.47 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (134534768..134640342)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (134829007..134934581)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel antidiuretic hormone governs tumour-induced renal dysfunction.
Title: A novel antidiuretic hormone governs tumour-induced renal dysfunction.
The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.
Title: The overexpression of neurokinin B-neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function.
Tachykinin receptor 3 in the lateral habenula alleviates pain and anxiety comorbidity in mice.
Title: Tachykinin receptor 3 in the lateral habenula alleviates pain and anxiety comorbidity in mice.
Neurokinin 3 receptor antagonist-induced adipocyte activation improves obesity and metabolism in PCOS-like mice.
Title: Neurokinin 3 receptor antagonist-induced adipocyte activation improves obesity and metabolism in PCOS-like mice.
Nk3R blockade has sex-divergent effects on memory in mice.
Title: Nk3R blockade has sex-divergent effects on memory in mice.
Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice.
Title: Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice.
A single-nucleotide polymorphism induced alternative splicing in Tacr3 involves in hypoxic-ischemic brain damage.
Title: A single-nucleotide polymorphism induced alternative splicing in Tacr3 involves in hypoxic-ischemic brain damage.
Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia.
Title: Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia.
we demonstrate that in the presence of E2, NKB signaling induces LH release in a kisspeptin-independent manner through the activation of NK3R (NKB receptor) neurons in the posterodorsal medial amygdala (MePD). Importantly, we show that chemogenetic activation of MePD Kiss1 neurons induces LH release, however, the stimulatory action of NKB in this area is Kiss1 neuron-independent.
Title: NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice.
Data suggest that neurokinin 3 receptor (NK3R) might be a potential target for the anti-angiogenesis therapy.
Title: Targeting neurokinin-3 receptor: a novel anti-angiogenesis strategy for cancer treatment.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

Tacr3 (e-PCR), detects polymorphism
- UniSTS:507269

Tacr3 (e-PCR), detects polymorphism
- UniSTS:144539

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables tachykinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tachykinin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of uterine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm midpiece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuromedin-K receptor

Names: NK-3 receptor; Nk3 receptor; neurokinin 3 receptor; neurokinin B receptor; neuromedin K receptor

NP_067357.1

EC 2.7.11.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.