Olfm4 olfactomedin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Olfm4provided by MGI
Official Full Name: olfactomedin 4provided by MGI
Primary source: MGI:MGI:2685142
See related: Ensembl:ENSMUSG00000022026 AllianceGenome:MGI:2685142
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GC1; OlfD; pPD4; GW112; Gm296; Gm913
Summary: Predicted to enable cadherin binding activity and structural molecule activity. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling and negative regulation of immune response. Located in extracellular space. Is expressed in bone marrow; colon; intestine; metanephros; and small intestine. Orthologous to human OLFM4 (olfactomedin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 97.6), liver E18 (RPKM 39.9) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 42.78 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (80237742..80260581)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (80000302..80023141)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Olfactomedin-4 deletion exacerbates DSS-induced colitis through a matrix metalloproteinase-9-dependent mechanism.
Title: Olfactomedin-4 deletion exacerbates DSS-induced colitis through a matrix metalloproteinase-9-dependent mechanism.
OLFM4 deficiency delays the progression of colitis to colorectal cancer by abrogating PMN-MDSCs recruitment.
Title: OLFM4 deficiency delays the progression of colitis to colorectal cancer by abrogating PMN-MDSCs recruitment.
These results demonstrate renal expression of OLFM4 for the first time and suggest that a kidney-specific mechanism may contribute to survival differences in OLFM4-null animals.
Title: Juvenile OLFM4-null mice are protected from sepsis.
High OLFM4 expression is associated with intestinal ischemia/reperfusion injury.
Title: The olfactomedin-4 positive neutrophil has a role in murine intestinal ischemia/reperfusion injury.
Olfm4 contributes to H2O2-induced NADPH oxidase activation.
Title: Olfactomedin 4 contributes to hydrogen peroxide-induced NADPH oxidase activation and apoptosis in mouse neutrophils.
Studies suggest that Olfm4 negatively regulates glucose-stimulated insulin secretion.
Title: Olfactomedin 4 Deletion Improves Male Mouse Glucose Intolerance and Insulin Resistance Induced by a High-Fat Diet.
OLFM4 has an important role in the regulation of intestinal inflammation and tumorigenesis, and could be a potential therapeutic target for intestinal malignant tumors. Unlike the human colonic epithelium, the mouse colonic epithelium does not express OLFM4, but nevertheless, systemic OLFM4 deletion promotes colon tumorigenesis and that loss from mucosal neutrophils may have a role to play.
Title: Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice.
olfactomedin 4 appears to play a critical role in regulating progression of prostate cancer, and has potential as a new biomarker for prostate cancer.
Title: Olfactomedin 4 deficiency promotes prostate neoplastic progression and is associated with upregulation of the hedgehog-signaling pathway.
OLFM4 may function as a tumor suppressor and an anti-metastatic gene during tumor progression
Title: Olfactomedin 4 suppresses tumor growth and metastasis of mouse melanoma cells through downregulation of integrin and MMP genes.
Olfm4 deletion can successfully enhance immune defense against S. aureus, but not A. fumigatus, in chronic granulomatous disease mice.
Title: Olfm4 deletion enhances defense against Staphylococcus aureus in chronic granulomatous disease.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

Olfm4 (e-PCR), detects polymorphism
- UniSTS:463215

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in specific granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: olfactomedin-4

Names: OLM4; PU.1 difference product 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001351947.1 → NP_001338876.1 olfactomedin-4 precursor

Status: VALIDATED

Source sequence(s)

AK133536, BQ179233

Consensus CDS

CCDS36989.2

UniProtKB/Swiss-Prot

Q3UZZ4

UniProtKB/TrEMBL

B2RUF9, B7ZNU5

Related

ENSMUSP00000154285.2, ENSMUST00000228749.2

Conserved Domains (2) summary

pfam02191
Location:243 → 495

OLF; Olfactomedin-like domain

pfam04849
Location:104 → 225

HAP1_N; HAP1 N-terminal conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

80237742..80260581

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001030294.1: Suppressed sequence

Description

NM_001030294.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.