Ppp3r2 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp3r2provided by MGI
Official Full Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)provided by MGI
Primary source: MGI:MGI:107171
See related: Ensembl:ENSMUSG00000028310 AllianceGenome:MGI:107171
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CnB2; CaNB2
Summary: Predicted to enable calcium-dependent protein serine/threonine phosphatase activity. Predicted to act upstream of or within defense response; glycogen metabolic process; and sperm displacement. Is expressed in brain; heart; lung; male reproductive gland or organ; and renal vasculature. Orthologous to human PPP3R2 (protein phosphatase 3 regulatory subunit B, beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 63.5) See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 26.75 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (49678747..49681983, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (49678747..49681983, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dependence of sperm structural and functional integrity on testicular calcineurin isoform PPP3R2 expression.
Title: Dependence of sperm structural and functional integrity on testicular calcineurin isoform PPP3R2 expression.
surgical-induced Osteoarthritis mice treated with a miR-146a inhibitor significantly alleviated the destruction of articular cartilage via targeting Camk2d and Ppp3r2.
Title: miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2.
this stusy demonstrates that male mice lacking Ppp3cc or Ppp3r2 genes (knockout mice) are infertile, with reduced sperm motility owing to an inflexible midpiece.
Title: Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive.
we report that calcineurin subunit B interacted with TLR4, which in turn led to phosphorylaiton of IRF3 and secretion of IFN-beta
Title: Calcineurin subunit B upregulates β-interferon production by phosphorylation of interferon regulatory factor 3 via Toll-like receptor 4.
The CnB could be of use as a prophylactic adjuvant as it is a human-derived safe agent and has immune-modulating effects that promote the control of cancer and infectious diseases.
Title: Calcineurin subunit B activates dendritic cells and acts as a cancer vaccine adjuvant.
Deactivation of calcineurin/NFAT pathway-induced pathological hypertrophy is a preferential mechanism by which exercise training leads to the cardiac anti-remodelling effect in heart failure.
Title: Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice.
neuronal CaN plays an opposite role in the formation of contextual fear memories and the extinction of previously formed contextual fear memories
Title: Transgenic inhibition of neuronal calcineurin activity in the forebrain facilitates fear conditioning, but inhibits the extinction of contextual fear memories.
Together, these findings reveal a previously unknown mechanism for the control of emotional memory that depends on CaN and Zif268.
Title: Control of the establishment of aversive memory by calcineurin and Zif268.
By several different criteria, calcineurin is dispensable for B cell tolerance, indicating that this phosphatase complex modulates immunogenic, but not tolerogenic, responses in vivo.
Title: The calcineurin phosphatase complex modulates immunogenic B cell responses.
Mice with genetic deletion of the calcineurin Abeta gene had a marked decrease in type II Na/Pi mRNA levels and remarkably did not show the expected increase in type II Na/Pi mRNA levels after the challenge of a low-Pi diet
Title: Calcineurin Abeta is central to the expression of the renal type II Na/Pi co-transporter gene and to the regulation of renal phosphate transport.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1) 1 citation

General gene information

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Markers

Ppp3r2 (e-PCR), detects polymorphism
- UniSTS:532285

Ppp3r1 (e-PCR), detects polymorphism
- UniSTS:499107

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium-dependent protein serine/threonine phosphatase regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of calcium ion import across plasma membrane	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within penetration of zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcineurin-NFAT signaling cascade	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of calcium ion import across plasma membrane	NAS Non-traceable Author Statement more info	PubMed
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcineurin complex	IDA Inferred from Direct Assay more info	PubMed
part_of calcineurin complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of calcineurin complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of protein serine/threonine phosphatase complex	NAS Non-traceable Author Statement more info	PubMed
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed
located_in sperm mitochondrial sheath	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcineurin subunit B type 2

Names: PP2B beta 2; calcineurin B subunit; protein phosphatase 2B regulatory subunit 2

NP_001004025.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004025.4 → NP_001004025.1 calcineurin subunit B type 2

See identical proteins and their annotated locations for NP_001004025.1

Status: PROVISIONAL

Source sequence(s)

AL732521

Consensus CDS

CCDS18179.1

UniProtKB/Swiss-Prot

Q63811

UniProtKB/TrEMBL

Q497S1

Related

ENSMUSP00000029991.3, ENSMUST00000029991.3

Conserved Domains (2) summary

PTZ00184
Location:17 → 153

PTZ00184; calmodulin; Provisional

cd00051
Location:91 → 158

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...